Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review

Duttaroy, Asim K.

doi:10.20944/preprints202012.0136.v1

Cited by 10 publications

(10 citation statements)

References 167 publications

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“…It is analyzed from the perspective of microbiota that succinate-utilizing Phascolarctobacterium is less abundant in both ulcerative colitis and Crohn’s disease than in healthy subjects. Some researchers make efforts to find the effect of important metabolite and the role of gut microbiota[ 157 ].…”

Section: Other Associated Metabolitesmentioning

confidence: 99%

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Wen¹,

Duan²

2022

WJCC

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Over the past two decades, it is improved gut microbiota plays an important role in the health and disease pathogenesis. Metabolites, small molecules produced as intermediate or end products of microbial metabolism, is considered as one of the major interaction way for gut microbiota with the host. Bacterial metabolisms of dietary substrates, modification of host molecules or bacteria are the major source of metabolites. Signals from microbial metabolites affect immune maturation and homeostasis, host energy metabolism as well as mucosal integrity maintenance. Based on many researches, the composition and function of the microbiota can be changed, which is also seen in the metabolite profiles of patients with inflammatory bowel disease (IBD). Additionally, some specific classes of metabolites also can trigger IBD. In this paper, definition of the key classes of microbial-derived metabolites which are changed in IBD, description of the pathophysiological basis of association and identification of the precision therapeutic modulation in the future are the major contents.

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Section: Other Associated Metabolitesmentioning

confidence: 99%

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Wen¹,

Duan²

2022

WJCC

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“…5 Several risk factors play a role in the progression of CVD, such as genetics, epigenetics, and lifestyles; the microbial population is known as microbiota and is another factor that has lately been studied. 8 The human microbiota is a collection of trillions of different microbes that inhabit the human body 9 ; these microbiotas live in symbiosis with a wide range of communities, which are thought to have an impact on health and disease. 10 Previously, the blood was thought to be immune-privileged, and microbial infiltration into the blood was only associated with infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

“…The human microbiota is a collection of trillions of different microbes that inhabit the human body 9 ; these microbiotas live in symbiosis with a wide range of communities, which are thought to have an impact on health and disease 10 . Previously, the blood was thought to be immune‐privileged, and microbial infiltration into the blood was only associated with infectious diseases 11 .…”

Section: Introductionmentioning

confidence: 99%

Exploring blood microbial communities and their influence on human cardiovascular disease

Khan

Zhou

et al. 2022

Clinical Laboratory Analysis

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Background Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating microbiome or the blood microbiome has been analyzed recently in chronic inflammatory diseases, including CVD in humans. Methods For this review, all relevant original research studies were assessed by searching in electronic databases, including PubMed, Google Scholar, and Web of Science, by using relevant keywords. Results This review demonstrated that elevated markers of systemic bacterial exposure are associated with noncommunicable diseases, including CVD. Studies have shown that the bacterial DNA sequence found in healthy blood belongs mainly to the Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla. In cardiac events, such as stroke, coronary heart disease, and myocardial infarction, the increased proportion of Proteobacteria and Actinobacteria phyla was found. Lipopolysaccharides are a major component of Proteobacteria, which play a key role in the onset of CVD. Moreover, recently, a study reported the lower cholesterol‐degrading bacteria, including Caulobacterales order and Caulobacteraceae family were both considerably reduced in myocardial infarction. Conclusion Proteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD.

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“…It was shown that TMAO is involved in all stages of atherogenesis, from the initial plaque formation to the terminal stage of thrombotic complications [ 37 ]. Several mechanisms for the role of TMAO in the development of atherosclerosis have been proposed, including the modulation of inflammation, cholesterol metabolism, and platelet activity.…”

Section: Discussionmentioning

confidence: 99%

Trimethylamine N-Oxide, a Gut Microbiota-Derived Metabolite, Is Associated with Cardiovascular Risk in Psoriasis: A Cross-Sectional Pilot Study

Sikora

Kiss

Stec

et al. 2021

Dermatol Ther (Heidelb)

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Introduction: Trimethylamine N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, is involved in the pathogenesis of atherosclerosis and cardiovascular diseases. Psoriasis is associated with increased cardiovascular risk that is not captured by traditional biomarkers. The aim of the present study was to assess TMAO concentration in psoriasis and evaluate the relationship between TMAO and cardiovascular risk in psoriatic patients. Methods: In 72 patients with psoriasis and 40 age-and sex-matched non-psoriatic controls, we evaluated fasting plasma TMAO, measured by high-performance liquid chromatography, and cardiovascular risk assessed by various scoring systems such as Framingham, QRISK2, AHA/ACC, and Reynolds risk scores. Results: In patients with psoriasis, TMAO concentration was significantly higher than in the control group (195.68 [133.54-332.58] ng/ml versus 126. 06 [84.29-156.88] ng/ml, respectively; p \ 0.001). Plasma TMAO concentration was significantly correlated with age, total cholesterol, triglycerides, systolic and diastolic blood pressure. Furthermore, the receiver-operating characteristic (ROC) and multiple regression analysis showed that TMAO is an independent predictor of cardiovascular risk. Conclusion: TMAO is a valuable candidate for biomarker and a translational link between dysbiosis and atherosclerosis in psoriasis.

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Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review

Cited by 10 publications

References 167 publications

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Exploring blood microbial communities and their influence on human cardiovascular disease

Trimethylamine N-Oxide, a Gut Microbiota-Derived Metabolite, Is Associated with Cardiovascular Risk in Psoriasis: A Cross-Sectional Pilot Study

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