1999
DOI: 10.1007/bf02432787
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Role of guanylate cyclase and arachidonic acid metabolites in the regulation of epithelium-dependent relaxation of tracheal smooth muscles in rats

Abstract: The effects of guanylate cyclase modulators and inhibitors of the arachidonic acid metabolism on epithelium-dependent smooth muscle reactions of rat tracheal segments were studied by a mechanographic technique. Application of phenylephrine to the tracheal segments precontracted by high-potassium Krebs' solution reduced their mechanical tension. This reaction was considerably less pronounced in the tracheal segments from which the epithelium had been removed. Phenylephrine-induced relaxation was suppressed by p… Show more

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