Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis

Liu, Xuanqi; Zhang, Linlin; Zhu, Bijun; Liu, Yifei; Li, Liyang; Hou, Jiayun; Qian, Mengjia; Zheng, Nannan; Zeng, Yiming; Chen, Chengshui; Goel, Ajay; Wang, Xiangdong

doi:10.1007/s10565-023-09799-5

Cited by 1 publication

(2 citation statements)

References 68 publications

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“…Cigarettes were combusted using a modified 50 mL syringe apparatus, in the presence of 5 mL of RPMI‐1640 medium devoid of serum. The quality of CSE was assessed by quantifying the absorbance value at a wavelength of 320λ (1.158), as reported previously 2,3,19 …”

Section: Methodsmentioning

confidence: 99%

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Roles of glutamic pyruvate transaminase 2 in reprogramming of airway epithelial lipidomic and metabolomic profiles after smoking

Yan,

Zhang,

Duan

et al. 2024

Clinical & Translational Med

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Metabolic abnormalities represent one of the pathological features of chronic obstructive pulmonary disease (COPD). Glutamic pyruvate transaminase 2 (GPT2) is involved in glutamate metabolism and lipid synthesis pathways, whilst the exact roles of GPT2 in the occurrence and development of COPD remains uncertain. This study aims at investigating how GPT2 and the associated genes modulate smoking‐induced airway epithelial metabolism and damage by reprogramming lipid synthesis. The circulating or human airway epithelial metabolomic and lipidomic profiles of COPD patients or cell‐lines explored with smoking were assessed to elucidate the pivotal roles of GPT2 in reprogramming processes. We found that GPT2 regulate the reprogramming of lipid metabolisms caused by smoking, especially phosphatidylcholine (PC) and triacylglycerol (TAG), along with changes in the expression of lipid metabolism‐associated genes. GPT2 modulated cell sensitivities and survival in response to smoking by enhancing mitochondrial functions and maintaining lipid and energy homeostasis. Our findings provide evidence for the involvement of GPT2 in the reprogramming of airway epithelial lipids following smoking, as well as the molecular mechanisms underlying GPT2‐mediated regulation, which may offer an alternative of therapeutic strategies for chronic lung diseases.

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Section: Methodsmentioning

confidence: 99%

“…The quality of CSE was assessed by quantifying the absorbance value at a wavelength of 320λ (1.158), as reported previously. 2 , 3 , 19 …”

Section: Methodsmentioning

confidence: 99%

Roles of glutamic pyruvate transaminase 2 in reprogramming of airway epithelial lipidomic and metabolomic profiles after smoking

Yan,

Zhang,

Duan

et al. 2024

Clinical & Translational Med

Self Cite

View full text Add to dashboard Cite

show abstract

Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis

Cited by 1 publication

References 68 publications

Roles of glutamic pyruvate transaminase 2 in reprogramming of airway epithelial lipidomic and metabolomic profiles after smoking

Roles of glutamic pyruvate transaminase 2 in reprogramming of airway epithelial lipidomic and metabolomic profiles after smoking

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