Role of growth hormone (GH) in the treatment on neural diseases: From neuroprotection to neural repair

Arce, V.; Devesa, Pablo; Devesa, Jesús

doi:10.1016/j.neures.2013.03.014

Cited by 61 publications

(53 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although some of the beneficial effects of GH on brain repair may depend on their neuroprotective actions [33], there is also accumulating evidence indicating that neurogenesis is also stimulated by GH. Thus GH treatment has been demonstrated to promote neurogenesis in different brain areas [20, 23, 24, 35] either under unperturbed conditions [20, 35] or in response to brain damage [23, 24]. Interestingly, GH-induced neurogenesis is potentiated when GH treatment is combined with physical exercise [35, 36] or physical rehabilitation [24], thus suggesting that the hormone is not only cooperating with endogenous mechanisms regulating postnatal neurogenesis, but may be even essential to induce the neurogenic response [36].…”

Section: Discussionmentioning

confidence: 99%

Growth hormone pathways signaling for cell proliferation and survival in hippocampal neural precursors from postnatal mice

et al. 2014

Self Cite

View full text Add to dashboard Cite

BackgroundAccumulating evidence suggests that growth hormone (GH) may play a major role in the regulation of postnatal neurogenesis, thus supporting the possibility that it may be also involved in promoting brain repair after brain injury. In order to gain further insight on this possibility, in this study we have investigated the pathways signaling the effect of GH treatment on the proliferation and survival of hippocampal subgranular zone (SGZ)-derived neurospheres.ResultsOur results demonstrate that GH treatment promotes both proliferation and survival of SGZ neurospheres. By using specific chemical inhibitors we have been also able to demonstrate that GH treatment promotes the activation of both Akt-mTOR and JNK signaling pathways, while blockade of these pathways either reduces or abolishes the GH effects. In contrast, no effect of GH on the activation of the Ras-ERK pathway was observed after GH treatment, despite blockade of this signaling path also resulted in a significant reduction of GH effects. Interestingly, SGZ cells were also capable of producing GH, and blockade of endogenous GH also resulted in a decrease in the proliferation and survival of SGZ neurospheres.ConclusionsAltogether, our findings suggest that GH treatment may promote the proliferation and survival of neural progenitors. This effect may be elicited by cooperating with locally-produced GH in order to increase the response of neural progenitors to adequate stimuli. On this view, the possibility of using GH treatment to promote neurogenesis and cell survival in some acquired neural injuries may be envisaged.

show abstract

Section: Discussionmentioning

confidence: 99%

Growth hormone pathways signaling for cell proliferation and survival in hippocampal neural precursors from postnatal mice

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…We used GH, although there was no deficit of the hormone, because of its well-known effects on brain repair after an injury [23][24][25][26][27]. In fact, one of us (JD) was the first (December 2002) in using GH to treat early a young man with a diffuse axonal injury, traumatic SHA and brainstem affectation, whose vital future was unpredictable.…”

Section: Discussionmentioning

confidence: 99%

“…GH plays a key role in neural development [34] and also exerts important neuroprotective and neuroregenerative effects [24,26,27,[34][35][36][37]. Particularly, the hormone plays a significant role at the cognitive level [25][26][27][38][39][40][41][42][43][44], even in the case that no GH-deficiency exists.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Evolution of a Patient Who Suffered a Subarachnoid Haemorrhage Eight Years Ago, after Being Treated with Growth Hormone, Melatonin and Neurorehabilitation

Quintana¹,

Agra²,

Outeiral³

et al. 2018

Reports

Self Cite

View full text Add to dashboard Cite

Abstract:To describe the cognitive evolution of a patient who suffered a subarachnoid haemorrhage resulting in a total loss of his cognitive functions. The patient was initially treated with GH (0.8 mg/day), melatonin (50 mg/day) and neurorehabilitation 1 year after his brain damage, during 3 months. Then continued with GH (0.5 mg/day, 6 months/year, during 2 years) and melatonin treatments and neurorehabilitation (3 days/week). 5 years later the patient came back to our Centre due to the absence of recent memory and personal and spatio-temporal orientation and he received an intensive specific neurorehabilitation, including EINA (Auditory Stimulation and Neurosensory Integration), together with GH (0.8 mg/day) and melatonin, for 6 months. At discharge of his first treatment period cognitive functions showed very poor changes but these had been improved when he came back 5 years later. A review carried out 8 years after SHA demonstrated that the patient significantly recovered in all the cognitive functions and he was able to live an independent life. GH plays a key role on cognition, including its actions on recent memory. Melatonin, in turn, helps as a neuroprotective agent. A specific neurostimulation must be performed so that the effects of GH can be expressed. Within neurostimulation, EINA seems to play a very important role for enhancing the effects of medical and rehabilitative treatments on brain plasticity.

show abstract

“…We treated him according to our protocols for children with cerebral palsy, both in terms of medication received (GH and MT) and neurorehabilitation [22,23]. GH was prescribed not only because of the low height of the patient and low plasma IGF-I values, a very common finding in children with cerebral palsy [24], but also for the known effects of the hormone on brain repair after a damage [25][26][27][28], particularly on cognition, executive functions and working memory [27,[29][30][31][32]. These GH effects were also observed in the patient, as the great improvement in the BDIST showed (14 months in 16 months of treatment), mainly in areas related to cognitive functions.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Aicardi-Goutières Syndrome Who Showed a Positive Evolution after Being Treated with Growth Hormone, High Doses of Melatonin and Neurorehabilitation

Devesa¹,

Alonso²,

Porto³

et al. 2017

Preprint

Self Cite

View full text Add to dashboard Cite

1) Background:The Aicardi-Goutières syndrome (AGS) is a rare congenital disease which courses with severe psychomotor delay in neurodevelopment. We studied a 3-years and 4-months old child with very important growth and weight affectation, microcephaly and loss of his developmental skills from 16-months of age, in which previous metabolic and genetic studies discarded any abnormality. Therefore diagnosis was cerebral palsy of unknown etiology. He presented spastic paraparesia, poor fine motricity, cognitive impairment and absence of oral communication. One year after discharge, a de novo mutation was detected in a single nucleotide in the gene IFIH1: c.2317G>C, being then diagnosed of AGS. 2) Methods: Blood analysis showed very low IGF-1 and slightly elevated liver transaminases. Treatment consisted in GH (0.04 mg/kg/day), melatonin (20 mg/day, and after 3-months 50 mg/day), and daily intense neurorehabilitation (5 days/week). Tests for evaluating childhood developmental milestones (GMFM-88, BDIST and the WeeFim test) were carried out every 3-months. 3) Results: The equivalent age at admission (10-months) increased to 24-months at discharge. There were clear improvements in spasticity, fine motor function, swallowing, cognition and autonomy as well as in communication, growth and weight. 4) Conclusion: Most likely melatonin blocked or decreased the interferon signature, allowing GH and neurorehabiltation to act on neurodevelopment.

show abstract

Role of growth hormone (GH) in the treatment on neural diseases: From neuroprotection to neural repair

Cited by 61 publications

References 116 publications

Growth hormone pathways signaling for cell proliferation and survival in hippocampal neural precursors from postnatal mice

Growth hormone pathways signaling for cell proliferation and survival in hippocampal neural precursors from postnatal mice

Cognitive Evolution of a Patient Who Suffered a Subarachnoid Haemorrhage Eight Years Ago, after Being Treated with Growth Hormone, Melatonin and Neurorehabilitation

A Rare Case of Aicardi-Goutières Syndrome Who Showed a Positive Evolution after Being Treated with Growth Hormone, High Doses of Melatonin and Neurorehabilitation

Contact Info

Product

Resources

About

Role of growth hormone (GH) in the treatment on neural diseases: From neuroprotection to neural repair

Cited by 61 publications

References 116 publications

Growth hormone pathways signaling for cell proliferation and survival in hippocampal neural precursors from postnatal mice

Growth hormone pathways signaling for cell proliferation and survival in hippocampal neural precursors from postnatal mice

Cognitive Evolution of a Patient Who Suffered a Subarachnoid Haemorrhage Eight Years Ago, after Being Treated with Growth Hormone, Melatonin and Neurorehabilitation

A Rare Case of Aicardi-Gouti&egrave;res Syndrome Who Showed a Positive Evolution after Being Treated with Growth Hormone, High Doses of Melatonin and Neurorehabilitation

Contact Info

Product

Resources

About

A Rare Case of Aicardi-Goutières Syndrome Who Showed a Positive Evolution after Being Treated with Growth Hormone, High Doses of Melatonin and Neurorehabilitation