Role of gonadal hormones in anxiety and fear memory formation and inhibition in male mice

McDermott, Carmel M.; Liu, Dana; Schrader, Laura A.

doi:10.1016/j.physbeh.2011.12.016

Cited by 50 publications

(39 citation statements)

References 52 publications

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“…On the other hand, testosterone and its metabolites have been shown to possess anxiolytic properties, reducing anxiety behaviors and enhancing cognition in male rodents [269,270,271]. Testosterone has shown to influence the severity of tics, as anabolic androgens worsen tic severity in males with Tourette’s syndrome [272], whilst treatment with the 5α-reductase inhibitor, finasteride, decreased tic severity and compulsive symptoms in adult men with Tourette’s syndrome [273].…”

Section: Role Of Sex Hormones and Sex Chromosome Genes In Susceptimentioning

confidence: 99%

Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders

et al. 2018

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Males and females sometimes significantly differ in their propensity to develop neurological disorders. Females suffer more from mood disorders such as depression and anxiety, whereas males are more susceptible to deficits in the dopamine system including Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD) and autism. Despite this, biological sex is rarely considered when making treatment decisions in neurological disorders. A better understanding of the molecular mechanism(s) underlying sex differences in the healthy and diseased brain will help to devise diagnostic and therapeutic strategies optimal for each sex. Thus, the aim of this review is to discuss the available evidence on sex differences in neuropsychiatric and neurodegenerative disorders regarding prevalence, progression, symptoms and response to therapy. We also discuss the sex-related factors such as gonadal sex hormones and sex chromosome genes and how these might help to explain some of the clinically observed sex differences in these disorders. In particular, we highlight the emerging role of the Y-chromosome gene, SRY, in the male brain and its potential role as a male-specific risk factor for disorders such as PD, autism, and ADHD in many individuals.

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Section: Role Of Sex Hormones and Sex Chromosome Genes In Susceptimentioning

confidence: 99%

Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders

et al. 2018

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“…Testosterone and its metabolites have been shown to possess anxiolytic properties, reducing anxiety behaviors and enhancing cognition in male rodents (Frye, Koonce, Edinger, Osborne, & Walf, 2008; Hodosy et al, 2012; McDermott, Liu, & Schrader, 2012). Findings for the role of testosterone in fear conditioning and extinction are not yet clear.…”

Section: Gonadal Hormones Stress and Fear Extinctionmentioning

confidence: 99%

Sex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones

Maeng

Milad

2015

Hormones and Behavior

299

199

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Women are more vulnerable to stress- and fear-based disorders, such as anxiety and post-traumatic stress disorder. Despite the growing literature on this topic, the neural basis of these sex differences remains unclear, and the findings appear inconsistent. The neurobiological mechanisms of fear and stress in learning and memory processes have been extensively studied, and the crosstalk between these systems is beginning to explain the disproportionate incidence and differences in symptomatology and remission within these psychopathologies. In this review, we discuss the intersect between stress and fear mechanisms and their modulation by gonadal hormones and discuss the relevance of this information to sex differences in anxiety and fear-based disorders. Understanding these converging influences is imperative to the development of more effective, individualized treatments that take sex and hormones into account.

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“…TP administration could recover the above behaviours of the GX rats and could decrease the anxiety-like behaviours of the GX rats. Testosterone administration in GX male rats decreased indices of anxiety [25]. The results of these experiments suggested that preventing the increase in gonadal steroids during adolescence alters responses during open field behaviours in adult male rats, and pubertal hormones acting on the adolescent brain exert long-term influences on adult behaviour.…”

Section: Discussionmentioning

confidence: 82%

The effects of gonadectomy and binge-like ethanol exposure during adolescence on open field behaviour in adult male rats

Yan

Kang

Zhang

et al. 2015

Neuroscience Letters

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Role of gonadal hormones in anxiety and fear memory formation and inhibition in male mice

Cited by 50 publications

References 52 publications

Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders

Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders

Sex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones

The effects of gonadectomy and binge-like ethanol exposure during adolescence on open field behaviour in adult male rats

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