Role of Glutamine-Glutamate/GABA cycle and potential target GLUD2 in alleviation of rheumatoid arthritis by Tripterygium hypoglaucum (levl.) Hutch based on metabolomics and molecular pharmacology

Long, Chengyan; Yang, Yang; Wang, Yunlong; Zhang, Xiaomei; Zhang, Li; Huang, Sixing; Yang, Da; Qiao, Xingfang; Yang, Yong; Guo, Yanlei

doi:10.1016/j.jep.2021.114561

Cited by 9 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metabolomics, which is characterized by rapid, convenient, and high-throughput data generation, can be used to qualitatively and quantitatively analyze metabolites in whole organisms or cells ( Feng et al, 2020 ) and to determine related metabolic processes ( Mohammat et al, 2017 ; Long et al, 2021 ). With new analytical technologies and comprehensive compound mass spectrometry databases, metabolomics has become an important tool for studying plant physiology, especially in the study of plant stress resistance ( Zhao et al, 2021 ), flower and fruit development ( Yang et al, 2019 ; Yu et al, 2019 ), and food quality dynamics ( Xiao et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolomic analysis reveals dynamic changes in secondary metabolites of Sophora japonica L. during flower maturation

Wang

Song

et al. 2022

Front. Plant Sci.

Self Cite

View full text Add to dashboard Cite

Sophora japonica L. is widely consumed in China because of its medicinal and nutritional value. Its quality is greatly affected by the accumulation of metabolites, which varies with the stage of flower development. However, changes in the characteristics of the secondary metabolites during flower maturity remain unclear. Ultra-high-performance liquid chromatography coupled with electrospray ionization-triple quadrupole-linear ion trap mass spectrometry (UPLC–ESI–QTRAP–MS/MS) revealed dynamic changes in the secondary metabolites of S. japonica during the five flower-maturity stages. We monitored 331 metabolites and screened 164. The differential metabolites showed seven trends during flower maturation, with flavonoids and phenolic acids having the most varied expressions. Flower buds (S2–S3) are rich in flavonoids and are thus suitable for use in high-quality medicine or industrial extraction. Our study provides an empirical basis for the informed harvesting of S. japonica based on its mode of utilization.

show abstract

Section: Introductionmentioning

confidence: 99%

Metabolomic analysis reveals dynamic changes in secondary metabolites of Sophora japonica L. during flower maturation

Wang

Song

et al. 2022

Front. Plant Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Also, Tripterygium wilfordii significantly inhibits the transcription and generation of IL-17 from murine splenocytes and purified CD4+ T cells by repressing IL-6-induced phosphorylation of STAT3 ( 88 ). The animal experiments also show that it could apparently relieve joint pain and swelling by suppressing the releases of IL-1α, IL-1βIL-4, IL-10 and MMP3 ( 89 ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of TCMs with anti-inflammatory effect in patients with rheumatoid arthritis: A network meta-analysis

et al. 2023

View full text Add to dashboard Cite

BackgroundTraditional Chinese medicines (TCMs), such as Tripterygium wilfordii Hook F (TwHF), Glycyrrhiza uralensis, Caulis sinomenii and others have anti-inflammatory effects. They are widely used in China to treat rheumatoid arthritis (RA), but proof of their use as an evidence-based medicine is little. The aim of this network meta-analysis (NMA) was to evaluate the efficacy and safety of TCMs.MethodsBy searching online databases and using a manual retrieval method, randomized controlled trials (RCTs) that met specific selection criteria were included in the meta-analysis. The search included papers that were published between the establishment of the databases and November 10, 2022. Analyses were performed using Stata software (version 14) and Review Manager (version 5.3).Results61 papers with 6316 subjects were included in the current NMA. For ACR20, MTX plus SIN therapy (94.30%) may be a significant choice. For ACR50 and ACR70, MTX plus IGU therapy (95.10%, 75.90% respectively) performed better than other therapies. IGU plus SIN therapy (94.80%) may be the most promising way to reduce DAS-28, followed by MTX plus IGU therapy (92.80%) and TwHF plus IGU therapy (83.80%). In the analysis of the incidence of adverse events, MTX plus XF therapy (92.50%) had the least potential, while LEF therapy (22.10%) may cause more adverse events. At the same time, TwHF therapy, KX therapy, XF therapy and ZQFTN therapy were not inferior to MTX therapy.ConclusionsTCMs with anti-inflammatory effect were not inferior to MTX therapy in the treatment of RA patients. Combining with TCMs can improve the clinic efficacy and reduce the possibility of adverse events of DMARDs, which may be a promising regimen.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022313569.

show abstract

“…It is also involved in the production of neurotransmitters, which can affect the pathways of pain perception [36]. Studies have suggested that L-glutamine supplementation may help to reduce pain associated with conditions such as inflammatory bowel disease, chemotherapyinduced neuropathy, and irritable bowel syndrome [37]. This may be due to its ability to support tissue repair and reduce inflammation, as well as its potential role in modulating neurotransmitter levels.…”

Section: L-glutaminementioning

confidence: 99%

The Role of VARVIMAX™ In the Treatment of Chronic Inflammation and Pain in Arthritis and Fibromyalgia

Ullah

2023

JAMMR

View full text Add to dashboard Cite

Background: Arthritis and fibromyalgia are chronic inflammatory conditions that cause significant pain and discomfort in affected individuals. Current treatments, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are associated with adverse effects and do not always provide adequate relief. Therefore, there is a need for safe and effective treatments for chronic inflammation and pain in arthritis and fibromyalgia. Review of the Literature: This review aims to evaluate the safety and efficacy of VARVIMAX™, a dietary supplement derived from a plant extract, for managing chronic pain in arthritis and fibromyalgia. According to the literature, the prevalence of fibromyalgia and arthritis is still high and even these two conditions occur together. VARVIMAX™ is a dietary supplement derived from a plant extract. VARVIMAX™ contains high levels of anthocyanins, such as Astaxanthins have been shown to possess anti-inflammatory and antioxidant properties. The formulation includes amino acids and flavonoids such as choline L-bitartrate, GABA, L-arginine, black pepper (piperine), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), trans-resveratrol 98% (polygonum cuspidatum extract), which all have anti-inflammatory effects and play a significant role in pain management. Studies have shown that these ingredients have been effective in reducing pain, and inflammation, and improving joint function in patients with arthritis, fibromyalgia, and other inflammatory conditions. The most common side effects reported were gastrointestinal symptoms, such as nausea and diarrhea. Conclusion: VARVIMAX™, a dietary supplement derived from a plant extract Ephedra, shows promise as a safe and effective treatment for chronic pain in arthritis and fibromyalgia. It is composed of several anthocyanins, amino acids, and flavonoids that impart it its characteristic anti-inflammatory and antioxidant properties. This results in reducing pain and inflammation, and improving joint function. Further research is needed to establish its long-term safety and efficacy in a wider range of inflammatory conditions.

show abstract

Role of Glutamine-Glutamate/GABA cycle and potential target GLUD2 in alleviation of rheumatoid arthritis by Tripterygium hypoglaucum (levl.) Hutch based on metabolomics and molecular pharmacology

Cited by 9 publications

References 46 publications

Metabolomic analysis reveals dynamic changes in secondary metabolites of Sophora japonica L. during flower maturation

Metabolomic analysis reveals dynamic changes in secondary metabolites of Sophora japonica L. during flower maturation

Efficacy and safety of TCMs with anti-inflammatory effect in patients with rheumatoid arthritis: A network meta-analysis

The Role of VARVIMAX™ In the Treatment of Chronic Inflammation and Pain in Arthritis and Fibromyalgia

Contact Info

Product

Resources

About