Role of Glutamatergic Neurotransmission in the Pathophysiology of Stress-Related Disorders and Chronic Stress Response

Réus, Gislaine Z.; Abelaira, Helena M.; Coutellier, Laurence; Manosso, Luana M.; Pavlovic, Zoran M

doi:10.1007/978-3-030-87480-3_3

Cited by 2 publications

(1 citation statement)

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“…Stress causes activation and proliferation of microglia in the CNS, which may possibly mediate these cytokine effects [ 52 ]. Chronic stress is known to affect the glutamatergic system, ionotropic and metabotropic glutamate receptors and excitatory amino acid transporters [ 60 ], which may also play a role in the development of TRS, as it is associated with higher levels of glutamate in the anterior cingulate cortex [ 61 ].…”

Section: Pathogenetic Aspect Of Inflammation In Treatment Resistance ...mentioning

confidence: 99%

Cytokine Imbalance as a Biomarker of Treatment-Resistant Schizophrenia

Shnayder

Khasanova

Strelnik

et al. 2022

IJMS

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Treatment-resistant schizophrenia (TRS) is an important and unresolved problem in biological and clinical psychiatry. Approximately 30% of cases of schizophrenia (Sch) are TRS, which may be due to the fact that some patients with TRS may suffer from pathogenetically “non-dopamine” Sch, in the development of which neuroinflammation is supposed to play an important role. The purpose of this narrative review is an attempt to summarize the data characterizing the patterns of production of pro-inflammatory and anti-inflammatory cytokines during the development of therapeutic resistance to APs and their pathogenetic and prognostic significance of cytokine imbalance as TRS biomarkers. This narrative review demonstrates that the problem of evaluating the contribution of pro-inflammatory and anti-inflammatory cytokines to maintaining or changing the cytokine balance can become a new key in unlocking the mystery of “non-dopamine” Sch and developing new therapeutic strategies for the treatment of TRS and psychosis in the setting of acute and chronic neuroinflammation. In addition, the inconsistency of the results of previous studies on the role of pro-inflammatory and anti-inflammatory cytokines indicates that the TRS biomarker, most likely, is not the serum level of one or more cytokines, but the cytokine balance. We have confirmed the hypothesis that cytokine imbalance is one of the most important TRS biomarkers. This hypothesis is partially supported by the variable response to immunomodulators in patients with TRS, which were prescribed without taking into account the cytokine balance of the relation between serum levels of the most important pro-inflammatory and anti-inflammatory cytokines for TRS.

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Section: Pathogenetic Aspect Of Inflammation In Treatment Resistance ...mentioning

confidence: 99%

Cytokine Imbalance as a Biomarker of Treatment-Resistant Schizophrenia

Shnayder

Khasanova

Strelnik

et al. 2022

IJMS

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Neuroeconomic Insights on Addiction

Singha,

2024

Advances in Finance, Accounting, and Economics

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Addiction is considered a result of behaviour that has wandered at many levels, including neurophysiological, genetic predisposition, and environment. By taking a comprehensive approach, community-based initiatives and policy implications call for more than just curing. This chapter outlines the role of typical understanding in addiction treatment, prevention, and recovery. The multi-dimensional addiction behaviour scale, a method for the diagnosis of addictive behaviours, views addiction from different angles, such as psychological factors such as mental illness and genetic dispositions brought to us through biological inheritance and neurobiological changes by long-term drug abuse. Psychological factors, biological factors, social and environmental factors, cognitive and behavioural patterns, motivation and readiness for change are the possible multi-dimensions of addiction behaviour.

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Role of Glutamatergic Neurotransmission in the Pathophysiology of Stress-Related Disorders and Chronic Stress Response

Cited by 2 publications

References 303 publications

Cytokine Imbalance as a Biomarker of Treatment-Resistant Schizophrenia

Cytokine Imbalance as a Biomarker of Treatment-Resistant Schizophrenia

Neuroeconomic Insights on Addiction

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