Role of glucagon in metabolic acclimation to cold and heat

Kuroshima, Akihiro; Doi, Katsuhiko; Ohno, Tomie

doi:10.1016/0024-3205(78)90401-0

Cited by 53 publications

(19 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The body weight at the experiment was 266+3.3 g in WC, 232+4.8 g in CA (p vs. WC <0.001) and 173+3.3 g in HA (p vs. WC <0.001). Ponderal growth was significantly smaller in both CA and HA as previously reported (KUROSHIMA et al, 1978).…”

Section: Changes In Body Weightssupporting

confidence: 87%

“…We have proposed by a series of experiments that pancreatic hormone, glucagon, is closely associated A. KUROSHIMA, Y. HABARA, and T. OHNO with an enhanced NST in the cold-acclimated rats through its action on BAT (KUROSHIMA et al, 1978(KUROSHIMA et al, , 1979YAHATA et al, 1981). It has been shown that the sympathetic nervous system influences the pancreatic hormone secretion either neurally or by the release of adrenomedullary catecholamines.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Noradrenaline-induced secretions of pancreatic hormones in cold- and heat-acclimated rats.

1983

Self Cite

View full text Add to dashboard Cite

Effects of noradrenaline on the portal and aortic plasma pancreatic hormone concentrations were studied in the cold-and heatacclimated rats in order to know possible roles of these hormones in temperature acclimation. Noradrenaline (NA) infusion (2 ,ug/min, i.v., 30 min) effected greater elevation of colonic temperature (Ta) in the cold-acclimated rats (CA) than in the warm controls (WC), and did not influence T~ in the heat-acclimated rats (HA) under hexobarbital anesthesia. Portal and aortic glucagon levels increased in the NAinfused CA and HA, but no changes were observed in the NA-infused WC. NA-infusion did not affect the portal and aortic insulin levels in WC and CA, but increased aortic insulin level in HA. Aortic glycerol and free fatty acid (FFA) levels increased in all NA-infused groups. Portal and jugular vein FFA levels increased in NA-infused WC, but did not in NA-infused CA and HA. Neither NA infusion, nor glucagon was related to the elevation of T~ in HA. These results suggest that temperature acclimation modifies a glucagon-releasing action of NA and the NA-released glucagon could cooperate with NA to enhance nonshivering thermogenesis in the cold.

show abstract

Section: Changes In Body Weightssupporting

confidence: 87%

mentioning

confidence: 99%

Noradrenaline-induced secretions of pancreatic hormones in cold- and heat-acclimated rats.

1983

Self Cite

View full text Add to dashboard Cite

show abstract

“…Effect of cold acclimation. Plasma glucagon level has been reported to increase by about 100 to 1,000pg/ml (about 3 x 10-11 to 3 x 10-10 M) during cold exposure and cold acclimation (KUROSHIMA and Doi,1976;KUROSHIMA et al, 1978KUROSHIMA et al, , 1981SEITZ et al, 1981). Glucagon binding in the present assay was 0.5 to 2 x i0' -5 mol/105 cells for these levels of glucagon (Fig.…”

Section: Discussionsupporting

confidence: 47%

Effect of cold acclimation on glucagon receptors of rat white adipocytes.

1986

Self Cite

View full text Add to dashboard Cite

In order to determine the role of glucagon in cold acclimation, the changes in glucagon receptor were investigated in white adipocytes from cold-acclimated rats by establishing a glucagon radioreceptor assay method for isolated white adipocytes. The following conditions were found to be appropriate for specific glucagon receptor binding assay; cell concentration of about 1 x 105 cells/ml, 15 min preincubation with glucagon and 30 mm-reaction at 25°C in the presence of bacitracin (1 mg/ml). Cold acclimation decreased the size and increased the number of epididymal white adipocytes. Cold acclimation increased the number of glucagon receptors of white adipocytes, resulting in 140% in terms of unit cell, and 260% increase per unit surface area and 210% increase per whole tissue. However, the affinity of the binding site for glucagon was not affected. The results suggested that an enhanced metabolic response of cold-acclimated rats to glucagon could be partly explained by the increased number of glucagon receptor in white adipocytes.

show abstract

“…However, a series of reports from our laboratory has recently shown a possibility that pancreatic glucagon, another wellknown catabolic hormone as well as noradrenaline, is also involved in regulating calorigenic reponse of BAT through its lipolytic action during cold acclimation (KUROSHIMA and DoI, 1976). Substantial evidences of this view have been given by both in vivo (KUROSHIMA et al, 1978;DOI and KUROSHIMA, 1982) and in vitro (KUROSHIMA and YAHATA, 1979) experiments.…”

Section: Discussionmentioning

confidence: 93%