Role of genomic instability in arsenic-induced carcinogenicity. A review

Bhattacharjee, Pritha; Banerjee, Minakshi; Giri, Ashok K.

doi:10.1016/j.envint.2012.12.004

Cited by 120 publications

(75 citation statements)

References 216 publications

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“…4 C and D). Screens for DRC inhibitors or enhancers are expected to identify some agents for which the mechanism of action is unknown; indeed, uncertainty remains as to the precise mechanisms by which arsenic and cadmium exposure lead to reduced DRC (41,52). In view of this uncertainty, the strength of FM-HCR lies in the ability to measure changes in DRC as an important functional endpoint.…”

Section: Discussionmentioning

confidence: 99%

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis

Nagel

Margulies

Chaim

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

130

161

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The capacity to repair different types of DNA damage varies among individuals, making them more or less susceptible to the detrimental health consequences of damage exposures. Current methods for measuring DNA repair capacity (DRC) are relatively labor intensive, often indirect, and usually limited to a single repair pathway. Here, we describe a fluorescence-based multiplex flow-cytometric host cell reactivation assay (FM-HCR) that measures the ability of human cells to repair plasmid reporters, each bearing a different type of DNA damage or different doses of the same type of DNA damage. FM-HCR simultaneously measures repair capacity in any four of the following pathways: nucleotide excision repair, mismatch repair, base excision repair, nonhomologous end joining, homologous recombination, and methylguanine methyltransferase. We show that FM-HCR can measure interindividual DRC differences in a panel of 24 cell lines derived from genetically diverse, apparently healthy individuals, and we show that FM-HCR may be used to identify inhibitors or enhancers of DRC. We further develop a next-generation sequencing-based HCR assay (HCR-Seq) that detects rare transcriptional mutagenesis events due to lesion bypass by RNA polymerase, providing an added dimension to DRC measurements. FM-HCR and HCR-Seq provide powerful tools for exploring relationships among global DRC, disease susceptibility, and optimal treatment.

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Section: Discussionmentioning

confidence: 99%

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis

Nagel

Margulies

Chaim

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

130

161

View full text Add to dashboard Cite

show abstract

“…It was well documented that multiple factors, pathways and steps, including the external environment such as virus, parasite and bacterial, internal environment, contributed to the primary hepatic carcinoma (Clark et al, 2015). Generally, genetic factors could only account for 5% of the tumor pathogenesis, whereas the coefficient of external and internal environment showed its influence on most tumors (Bhattacharjee et al, 2013). The internal environment, considered appropriate for the development of carcinoma, are believed to be one of the most pivotal factors in the formation of tumors (Xu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

). Establishment and Evaluation of the Orthotopic Hepatocellular Carcinoma and Drug-Induced Hepatocellular Carcinoma in Mice With Spleen-Deficiency Syndrome in Traditional Chinese Medicine

Hy¹,

Chen²,

Sun³

et al. 2016

AJTCAM

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Background: Spleen-deficiency syndrome (SDS) in Traditional Chinese Medicine (TCM) played pivotal roles on the development of hepatocellular carcinoma (HCC). This study was performed to establish and evaluate HCC model in mice with SDS in TCM. Material and Methods: A total of 90 C57BL/6 mice were randomized in six groups (n=15 for each group): A, Control group; B, SDS group; C, orthotopic HCC (OHCC) group; D, OHCC based on SDS (SDS-OHCC) group; E, Druginduced HCC (DHCC) group; F, DHCC based on SDS (SDS-DHCC) group. The SDS model were established by subcutaneous injection of reserpine, followed by the OHCC or DHCC model establishment. The SDS scores, tumor formation rate and survival time were recorded and calculated, as well as the histochemical stain was performed. Conclusion:The SDS-oriented HCC mice models were simple and easily-operated models for further studies on SDS oriented tumor. Meanwhile, SDS was a pivotal factor for low outcome of hepatic tumor.

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“…Even moderately elevated concentrations of inorganic arsenic (iAs) in drinking water pose a serious public health problem [2]. Previous epidemiological studies of individuals exposed to high arsenic levels in drinking water suggest that chronic arsenic exposure via drinking water is widely associated with a higher risk of skin lesions, hypertension, diabetes, cardiovascular diseases, and cancer of the skin, lungs, bladder, liver, and possibly kidneys [2][3][4][5][6][7][8][9][10][11][12]. Therefore, the World Health Organization guideline for arsenic in drinking water is 10 μg/L [13].…”

Section: Introductionmentioning

confidence: 99%

Arsenic Metabolites and Methylation Capacity Among Individuals Living in a Rural Area with Endemic Arseniasis in Inner Mongolia, China

Wei

et al. 2015

Biol Trace Elem Res

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More than 0.3 million individuals are subject to chronic exposure to arsenic via their drinking water in Inner Mongolia, China. To determine arsenic methylation capacity profiles for such individuals, concentrations of urinary arsenic metabolites were measured for 548 subjects using high-performance liquid chromatography and a hydride generator combined with inductively coupled plasma-mass spectrometry. Mean urinary concentrations of dimethylarsonic acid (DMA), monomethylarsonic acid (MMA), inorganic arsenic (iAs), and total arsenic (TAs) were 200.50, 46.71, 52.96, and 300.17 μg/L, respectively. The %iAs, %DMA, and %MMA were 15.98, 69.72, and 14.29 %. Mean urinary %iAs and %MMA were higher in males, while urinary %DMA was higher in females. There was a strong positive correlation between %iAs and %MMA, with negative correlations between %iAs and %DMA, and %iAs and %MMA. In addition, %iAs and %MMA were positively associated with total arsenic in drinking water (WAs), while %DMA was negatively related with WAs. Regression analysis indicated that the primary methylation index (PMI) and secondary methylation index (SMI) generally decreased with increasing WAs. Females had a higher arsenic methylation capacity compared to males. Younger subjects had lower primary arsenic methylation capacity. However, the secondary arsenic methylation capacity was hardly affected by age. Moreover, both primary and secondary arsenic methylation capacities were negatively related to WAs.

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Role of genomic instability in arsenic-induced carcinogenicity. A review

Cited by 120 publications

References 216 publications

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis

). Establishment and Evaluation of the Orthotopic Hepatocellular Carcinoma and Drug-Induced Hepatocellular Carcinoma in Mice With Spleen-Deficiency Syndrome in Traditional Chinese Medicine

Arsenic Metabolites and Methylation Capacity Among Individuals Living in a Rural Area with Endemic Arseniasis in Inner Mongolia, China

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