Role of gene regulation in the anticancer activity of carotenoids

Sharoni, Yoav; Danilenko, Michael; Walfisch, Shlomo; Amir, Hadar; Nahum, Amit; Ben-Dor, Anat; Hirsch, Keren; Khanin, Marina; Steiner, Michael; Agemy, Lilach; Zango, Gabriel; Levy, Joseph

doi:10.1351/pac200274081469

Cited by 34 publications

(17 citation statements)

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“…hormones, antibodies, lipids), or carotenoid-driven mechanisms other than antioxidant action (e.g. regulation of immune-response genes; Sharoni et al 2002), affect immune-system organization or beak-color development.…”

Section: Discussionmentioning

confidence: 99%

Maternally derived carotenoid pigments affect offspring survival, sex ratio, and sexual attractiveness in a colorful songbird

McGraw

Adkins‐Regan

Parker

2005

Naturwissenschaften

193

209

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In egg-laying animals, mothers can influence the development of their offspring via the suite of biochemicals they incorporate into the nourishing yolk (e.g. lipids, hormones). However, the long-lasting fitness consequences of this early nutritional environment have often proved elusive. Here, we show that the colorful carotenoid pigments that female zebra finches (Taeniopygia guttata) deposit into egg yolks influence embryonic and nestling survival, the sex ratio of fledged offspring, and the eventual ornamental coloration displayed by their offspring as adults. Mothers experimentally supplemented with dietary carotenoids prior to egg-laying incorporated more carotenoids into eggs, which, due to the antioxidant activity of carotenoids, rendered their embryos less susceptible to free-radical attack during development. These eggs were subsequently more likely to hatch, fledge offspring, produce more sons than daughters, and produce sons who exhibited more brightly colored carotenoid-based beak pigmentation. Provisioned mothers also acquired more colorful beaks, which directly predicted levels of carotenoids found in eggs, thus indicating that these pigments may function not only as physiological 'damage-protectants' in adults and offspring but also as morphological signals of maternal reproductive capabilities.

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Section: Discussionmentioning

confidence: 99%

Maternally derived carotenoid pigments affect offspring survival, sex ratio, and sexual attractiveness in a colorful songbird

McGraw

Adkins‐Regan

Parker

2005

Naturwissenschaften

193

209

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“…Antiproliferative effects of lycopene have been reported in several cancer cell lines including those derived from prostate cancers and prostate epithelial cells [55, 80, 97, 107-122]. For example, a lower dose of lycopene inhibited the growth of LNCaP prostate cancer cells while a higher dose blocked cells in G2/M phase and induced apoptosis [112].…”

Section: Lycopene Tomatoes and Prostate Cancers: Mechanismsmentioning

confidence: 99%

“…Recent epidemiological studies suggested that higher dietary intake of lycopene is correlated with a lower circulating IGF-I and higher levels of IGFBPs [122, 130, 131]. Lycopene at pharmacologic concentrations inhibited prostate cancer cell IGF-I receptor expression and Akt phosphorylation [114].…”

Section: Lycopene Tomatoes and Prostate Cancers: Mechanismsmentioning

confidence: 99%

Tomato-based food products for prostate cancer prevention: what have we learned?

Tan

Thomas‐Ahner

Grainger

et al. 2010

Cancer Metastasis Rev

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Evidence derived from a vast array of laboratory studies and epidemiological investigations have implicated diets rich in fruits and vegetables with a reduced risk of certain cancers. However, these approaches cannot demonstrate causal relationships and there is a paucity of randomized, controlled trials due to the difficulties involved with executing studies of food and behavioral change. Rather than pursuing the definitive intervention trials that are necessary, the thrust of research in recent decades has been driven by a reductionist approach focusing upon the identification of bioactive components in fruits and vegetables with the subsequent development of single agents using a pharmacologic approach. At this point in time, there are no chemopreventive strategies that are standard of care in medical practice that have resulted from this approach. This review describes an alternative approach focusing upon development of tomato-based food products for human clinical trials targeting cancer prevention and as an adjunct to therapy. Tomatoes are a source of bioactive phytochemicals and are widely consumed. The phytochemical pattern of tomato products can be manipulated to optimize anticancer activity through genetics, horticultural techniques, and food processing. The opportunity to develop a highly consistent tomato-based food product rich in anticancer phytochemicals for clinical trials targeting specific cancers, particularly the prostate, necessitates the interactive transdisciplinary research efforts of horticulturalists, food technologists, cancer biologists, and clinical translational investigators.

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“…In addition, our results provide a basic knowledge about phytochemicals interactions with biological systems that may be useful for the design of functional foods. Sharoni et al [53] hypothesized that a single micronutrient cannot replace the power of the concerted action of multiple agents derived from a diet rich in fruits and vegetables.…”

Section: Discussionmentioning

confidence: 99%

Role of Zucchini and Its Distinctive Components in the Modulation of Degenerative Processes: Genotoxicity, Antigenotoxicity, Cytotoxicity and Apoptotic Effects

Martínez-Valdivieso¹,

Font²,

Fernández-Bedmar³

et al. 2017

Preprint

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Zucchini (Cucurbita pepo subsp. pepo) is a seasonal vegetable with high nutritional and medical value. Many useful properties of this fruit are attributed to its bioactive compounds. Zucchini fruits ("Yellow" and "Light Green" varieties) and four distinctive components (lutein, β-carotene, zeaxanthin and dehydroascorbic acid)were selected. Firstly it was determinated the lutein, β-carotene, zeaxanthin and dehydroascorbic acid content in these fruits and then, in order to measure the safety and suitability of their use different assays were carried out: (i) Genotoxicity and antigenotoxicity tests to determine the safety and DNA-protection against hydrogen peroxide; (ii) cytotoxicity and (iii) DNA fragmentation assay to evaluate the proapoptotic effect. Results showed that: (i) all the substances were non-genotoxic, (ii) all the substances were antigenotoxic except the highest concentration of lutein, (iii) "Yellow" Zucchini epicarp and mesocarp exhibited the highest cytotoxic activity (IC50 > 0.1 mg/mL and 0.2 mg/mL, respectively) and iv) "Light Green" Zucchini skin and pulp induced internucleosomal DNA fragmentation . To sump up, Zucchini fruit could play a positive role in human health and nutrition due to this fruit and its components were safe, able to inhibit significantly the H2O2-induced damage and exhibit antiproliferative and proapoptotic properties toward HL60 tumour cells. The information generated from this research should take into account to select potential accessions for breeding programs purposes.

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Role of gene regulation in the anticancer activity of carotenoids

Cited by 34 publications

References 0 publications

Maternally derived carotenoid pigments affect offspring survival, sex ratio, and sexual attractiveness in a colorful songbird

Maternally derived carotenoid pigments affect offspring survival, sex ratio, and sexual attractiveness in a colorful songbird

Tomato-based food products for prostate cancer prevention: what have we learned?

Role of Zucchini and Its Distinctive Components in the Modulation of Degenerative Processes: Genotoxicity, Antigenotoxicity, Cytotoxicity and Apoptotic Effects

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