Role of gene–gene/gene–environment interaction in the etiology of eastern Indian ADHD probands

Das, Manali; Bhowmik, Aneek Das; Bhaduri, Nipa; Sarkar, Keka; Ghosh, Paramita M.; Sinha, Swagata; Ray, Anirban; Chatterjee, Anindita; Mukhopadhyay, Kanchan

doi:10.1016/j.pnpbp.2010.12.027

Cited by 38 publications

(36 citation statements)

References 90 publications

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“…Apparently, genetic liability is a high risk factor for ADHD [46]. Gene polymorphisms vary among different ethnicities and may affect disease outcome by acting synergistically or antagonistically and thus, their combined effect becomes an important aspect to study in the disease etiology [6]. Furthermore, parents of children with ADHD differed by ethnicity in their utilization of certain parenting strategies.…”

Section: Discussionmentioning

confidence: 99%

Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: A meta-analysis

Pan

Lin

Xue

et al. 2015

Neuroscience Letters

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Section: Discussionmentioning

confidence: 99%

Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: A meta-analysis

Pan

Lin

Xue

et al. 2015

Neuroscience Letters

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“…Occurrence of different subtypes of ADHD has also been reported to be different in various ethnic groups; while the combined subtype predominated British [36], German [41] and Indian ( [42], present study) study subjects, only half of the US and Canadian patients belonged to combined category [3,20]. Difference in the risk allele/ haplotype frequencies in different ethnic groups could also be partly responsible for association with the disorder and the observed difference in subtype frequencies.…”

Section: Discussionmentioning

confidence: 52%

Role of SNAP25 Explored in Eastern Indian Attention Deficit Hyperactivity Disorder Probands

et al. 2011

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Synaptosomal-associated protein 25 (SNAP25) is an essential component for synaptic vesicle mediated release of neurotransmitters. Deficiencies or abnormal structure or function of SNAP25 protein, possibly arising through genetic variations in the relevant DNA code, has been suggested to play role in the pathology of several neurobehavioural disorders including Attention deficit Hyperactivity Disorder (ADHD) and a number of polymorphisms in the SNAP25 gene has been studied for association with the disorder. In the present investigation, for the first time association between ADHD and six SNAP25 polymorphisms, rs1889189, rs362569, rs362988, rs3746544, rs1051312, and rs8636 was explored in eastern Indian population. Subjects were recruited following the Diagnostic and Statistical Manual for Mental Disorders-IV. Genomic DNA isolated from peripheral blood leukocytes of ADHD probands (n = 150), their parents (n = 272) and ethnically matched controls (n = 100) was used for amplifying target sites. Data obtained were subjected to population- as well as family-based analyses. While case-control analysis revealed lack of any significant difference for alleles, family-based studies revealed a mild over transmission rs3746544 'T' and rs8636 'C' alleles (P = 0.05 and 0.03 respectively). Haplotypes formed between rs362569 "T", 362988 "G", rs3746544 "T", rs1051312 "T" and rs8636 "C" in different combinations showed statistically significant transmission to ADHD probands. Excepting rs3746544 and rs8636, all the tested sites showed very low linkage disequilibrium between them. Data obtained in this preliminary study indicates that rs3746544 'T' allele may have some role in the disease etiology in the studied Indian population.

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“…Strong genetic basis of ADHD is supported by twin, adoption, or family-based studies [4, 5]. A major role of genes regulating neurotransmitters, leading mainly to dopamine (DA) dysfunction, has been postulated in the disease etiology (reviewed in [6]).…”

Section: Introductionmentioning

confidence: 99%

“…The dopaminergic hypothesis of ADHD is based mostly on the malfunctioning of D2-like receptors in the brain [10, 11]. The DRD4 gene encoding for DA receptor 4 has been extensively studied, and positive associations with ADHD were reported in Caucasian as well as several non-Caucasian populations [5, 12–15]. The D2 and D3 receptors have been studied mostly in Caucasian and Chinese populations revealing inconsistent findings [16–18].…”

Section: Introductionmentioning

confidence: 99%

“…Genes encoding for enzymes involved in the catecholaminergic system like catechol-O-methyl transferase (COMT) [19, 20], dopamine decarboxylase (DDC) [21–23], dopamine beta hydroxylase [5, 15], and monoamine oxidase [15, 18, 22, 23] have also gained a lot of importance in exploring the etiological basis of ADHD. Some of these genetic variants have revealed significant association with ADHD associated co-morbid disorders [24] and were speculated as the reason for comorbidities being so common in Caucasian subjects with ADHD [25].…”

Section: Introductionmentioning

confidence: 99%

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Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands

Ghosh

Sarkar²,

Bhaduri

et al. 2013

BioMed Research International

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Contribution of genes in attention deficit hyperactivity disorder (ADHD) has been explored in various populations, and several genes were speculated to contribute small but additive effects. We have assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (rs1800496, rs1801028, and rs1799732), DRD4 (rs4646984 and rs4646983), and COMT (rs165599 and rs740603) in Indian ADHD subjects with comorbid attributes. Cases were recruited following the Diagnostic and Statistical Manual for Mental Disorders-IV-TR after obtaining informed written consent. DNA isolated from peripheral blood leukocytes of ADHD probands (N = 170), their parents (N = 310), and ethnically matched controls (n = 180) was used for genotyping followed by population- and family-based analyses by the UNPHASED program. DRD4 sites showed significant difference in allelic frequencies by case-control analysis, while DDC and COMT exhibited bias in familial transmission (P < 0.05). rs3837091 “AGAG,” rs3735273 “A,” rs1799732 “C,” rs740603 “G,” rs165599 “G” and single repeat alleles of rs4646984/rs4646983 showed positive correlation with co-morbid characteristics (P < 0.05). Multi dimensionality reduction analysis of case-control data revealed significant interactive effects of all four genes (P < 0.001), while family-based data showed interaction between DDC and DRD2 (P = 0.04). This first study on these gene variants in Indo-Caucasoid ADHD probands and associated co-morbid conditions indicates altered dopaminergic neurotransmission in ADHD.

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Role of gene–gene/gene–environment interaction in the etiology of eastern Indian ADHD probands

Cited by 38 publications

References 90 publications

Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: A meta-analysis

Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: A meta-analysis

Role of SNAP25 Explored in Eastern Indian Attention Deficit Hyperactivity Disorder Probands

Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands

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