Role of Gastrointestinal Permeability in Exertional Heatstroke

Lambert, G. P.

doi:10.1097/00003677-200410000-00011

Cited by 114 publications

(109 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During HS, blood flow is diverted from the splanchnic system to the skin in an attempt to dissipate excess heat (Lambert, 2009). Reduced blood flow and hyperthermia leads to hypoxia and oxidative and nitrosative stress in the enterocyte (Lambert, 2004;Pearce et al, 2013c). As a result, cell membranes and tight junctions can be damaged, leading to an increase in intestinal permeability, and this is also known as "leaky gut" (Lambert et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs1

Pearce

Fernández

Hollis

et al. 2014

Journal of Animal Science

144

111

View full text Add to dashboard Cite

Acute heat stress (HS) and heat stroke can be detrimental to the health, well-being, and performance of mammals such as swine. Therefore, our objective was to chronologically characterize how a growing pig perceives and initially copes with a severe heat load. Crossbred gilts (n=32; 63.8±2.9 kg) were subjected to HS conditions (37°C and 40% humidity) with ad libitum intake for 0, 2, 4, or 6 h (n=8/time point). Rectal temperature (Tr), respiration rates (RR), and feed intake were determined every 2 h. Pigs were euthanized at each time point and fresh ileum and colon samples were mounted into modified Ussing chambers to assess ex vivo intestinal integrity and function. Transepithelial electrical resistance (TER) and fluorescein isothiocyanate-labeled dextran (FD4) permeability were assessed. As expected, Tr increased linearly over time (P<0.001) with the highest temperature observed at 6 h of HS. Compared to the 0-h thermal-neutral (TN) pigs, RR increased (230%; P<0.001) in the first 2 h and remained elevated over the 6 h of HS (P<0.05). Feed intake was dramatically reduced due to HS and this corresponded with significant changes in plasma glucose, ghrelin, and glucose-dependent insulinotropic peptide (P<0.050). At as early as 2 h of HS, ileum TER linearly decreased (P<0.01), while FD4 linearly increased with time (P<0.05). Colon TER and FD4 changed due to HS in quadratic responses over time (P=0.050) similar to the ileum but were less pronounced. In response to HS, ileum and colon heat shock protein (HSP) 70 mRNA and protein abundance increased linearly over time (P<0.050). Altogether, these data indicated that a short duration of HS (2-6 h) compromised feed intake and intestinal integrity in growing pigs. KeywordsAnimal Science, appetite, heat stress, intestinal integrity, swine ABSTRACT: Acute heat stress (HS) and heat stroke can be detrimental to the health, well-being, and performance of mammals such as swine. Therefore, our objective was to chronologically characterize how a growing pig perceives and initially copes with a severe heat load. Crossbred gilts (n = 32; 63.8 ± 2.9 kg) were subjected to HS conditions (37°C and 40% humidity) with ad libitum intake for 0, 2, 4, or 6 h (n = 8/time point). Rectal temperature (T r ), respiration rates (RR), and feed intake were determined every 2 h. Pigs were euthanized at each time point and fresh ileum and colon samples were mounted into modified Ussing chambers to assess ex vivo intestinal integrity and function. Transepithelial electrical resistance (TER) and fluorescein isothiocyanate-labeled dextran (FD4) permeability were assessed. As expected, T r increased linearly over time (P < 0.001) with the highest temperature observed at 6 h of HS. Compared to the 0-h thermal-neutral (TN) pigs, RR increased (230%; P < 0.001) in the first 2 h and remained elevated over the 6 h of HS (P < 0.05). Feed intake was dramatically reduced due to HS and this corresponded with significant changes in plasma glucose, ghrelin, and glucose-dependent insulinotropic peptide (P < ...

show abstract

Section: Discussionmentioning

confidence: 99%

Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs1

Pearce

Fernández

Hollis

et al. 2014

Journal of Animal Science

144

111

View full text Add to dashboard Cite

show abstract

“…Another review published in 2004 has discussed a possible function of immune response in organ failure of patients suffering from hyperthermia during physical exercise [13] . Since a reduced splanchnic blood flow which can result in gastrointestinal barrier dysfunction and increased permeability can be measured, endotoxin causing immune reactions could enter internal organs and drive organ damage.…”

Section: Discussionmentioning

confidence: 99%

Are heat stroke and physical exhaustion underestimated causes of acute hepatic failure?

Weigand

Riediger²,

Stremmel³

et al. 2007

WJG

View full text Add to dashboard Cite

“…Furthermore, NSAIDs are likely to contribute to both the clotting abnormalities and the gastrointestinal cellular dysfunction that develop in hyperthermia. 36 Measuring a core rather than peripheral temperature is recommended, as a peripheral temperature may under-read by up to 2 C in hyperthermia. 37 …”

Section: Coolingmentioning

confidence: 99%

Drug-induced hyperthermia in critical care

Walter

Carraretto

2015

Journal of the Intensive Care Society

View full text Add to dashboard Cite

Fever is common in critically ill patients and the cause is frequently not infection. Drug fevers occur in the intensive care and there are many pharmacological agents, by a variety of mechanisms, which increase body temperature beyond normal range. This article is a review of the common classes of drugs that can induce hyperthermia, highlighting the deleterious effects of a sustained high temperature and outlining available treatments.

show abstract

Role of Gastrointestinal Permeability in Exertional Heatstroke

Cited by 114 publications

References 0 publications

Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs1

Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs1

Are heat stroke and physical exhaustion underestimated causes of acute hepatic failure?

Drug-induced hyperthermia in critical care

Contact Info

Product

Resources

About