Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia–reperfusion into gastric ulcers

Brzozowski, Tomasz; Konturek, Peter C.; Konturek, Stanisław J.; Drozdowicz, Danuta; Kwiecień, Sławomir; Pajdo, Robert; Bielański, Władysław; Hahn, Eckhart G.

doi:10.1016/s0014-2999(00)00287-9

Cited by 82 publications

(50 citation statements)

References 28 publications

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“…Adventitia is the plasma membrane. At present, it is considered that the digestive tract ulcer is caused by the imbalance between the attacking factors (gastric juice) that has the function of digestion and the defense factors (mucus, mucosa, blood stream of mucosa) that prevent the stomach and duodenum from being digested [15,[23][24][25][26][27][28][29][30][31][32] . In recent years, some experiments emphasize that the bloodstream of duodenal mucosa and the buffer capacity of mucosa endothelial cell are important factors that protect mucosa cell from being injured; experimental study of the stress ulcer shows that the nutrition of gastrointestinal tract (such as glucose) can prevent the stress ulcer [19] .…”

Section: Resultsmentioning

confidence: 99%

Analysis of the mechanisms of rabbit’s brainstem hemorrhage complicated with irritable changes in the alvine mucous membrane

Jin

Zheng²,

Shen³

et al. 2005

WJG

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AIM:To explore the dynamic changes in the pressure of the lateral ventricle during acute brainstem hemorrhage and the changes of neural discharge of vagus nerve under the load of intracranial hypertension, so as to analyze their effects on the congestive degree of intestinal mucous membrane and the morphologic changes of intestinal mucous membrane. METHODS:An operation was made to open the skull to obtain an acute brainstem hemorrhage animal model. Microcirculatory microscope photography device and video recording system were used to determine the changes continuously in the caliber of jejunal mesenteric artery during brainstem hemorrhage and the changes with time in the congestion of jejunal mucosal villi. We used HE stain morphology to analyze the changes of duodenal mucosal villi. A recording electrode was used to calculate and measure the electric discharge activities of cervical vagus nerve.

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Section: Resultsmentioning

confidence: 99%

Analysis of the mechanisms of rabbit’s brainstem hemorrhage complicated with irritable changes in the alvine mucous membrane

Jin

Zheng²,

Shen³

et al. 2005

WJG

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“…Regardless of the type of irritant that damages the gastric mucosa, production of these oxygen radicals plays a role in the tissue damage. It is well established that damaged tissue contains decreased levels of antioxidant enzymes and increased levels of lipid peroxidation products (1,(9)(10)(11)(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

“…Hypovolemia-related injury has not been studied adequately in animals. Currently, there are also no related human data available on this phase of tissue damage (9)(10)(11)(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Hypovolemia-related gastric tissue damage in the setting of upper gastrointestinal bleeding

Karıncaoğlu

Seçkin

Ateş³

et al. 2010

Turk J Gastroenterol

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“…Hang et al have shown that intestinal levels of TNF-α and IL-6 considerably increased after brain trauma [80]. Also, Brzozowski et al have shown that serum IL-1β increased after ischemia-reperfusion damage [92]. The results of Khaksari et al have shown that estradiol decreased intestinal levels of TNF-α, progesterone decreased serum levels of TNF-α and estrogen influenced intestinal levels of pro-inflammatory cytokines, especially TNF-α, which is probably mediated through estrogen receptor [93].…”

Section: Tbi Gi Tract and Sex Hormonesmentioning

confidence: 99%

Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

et al. 2017

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Traumatic brain injury (TBI) is an important public health problem which can lead to several complications like gastrointestinal dysfunction. Patients with TBI often suffer from gastrointestinal dysfunctions such as enteral feeding intolerance. Gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. TBI causes a delayed but significant decrease in intestinal contractile activity in the ileum leading to delayed transport. The association between severity of brain injury and enteral feeding intolerance suggests a strong link between the central nervous system and the non-functional gut. The results of recent basic and clinical studies revealed the beneficial effects of estrogen and progesterone hormones in the treatment of gastrointestinal dysfunction. Females have more resistance to stress and fewer gastrointestinal lesions occur in females as compared to males. Sex steroid hormones have sparked interest as possible neuroprotective agents after traumatic injury and many studies have been done on this subject. This article reviews the literature related to some possible physiological effects of female sexual hormones on the gastrointestinal tract following TBI.

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Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia–reperfusion into gastric ulcers

Cited by 82 publications

References 28 publications

Analysis of the mechanisms of rabbit’s brainstem hemorrhage complicated with irritable changes in the alvine mucous membrane

Analysis of the mechanisms of rabbit’s brainstem hemorrhage complicated with irritable changes in the alvine mucous membrane

Hypovolemia-related gastric tissue damage in the setting of upper gastrointestinal bleeding

Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

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