Role of Garlic in Chronic Diseases: Focusing on Gut Microbiota Modulation

Lim, Wei Quan; Cheam, Jia Ying; Law, Jodi Woan‐Fei; Letchumanan, Vengadesh; Lee, Learn‐Han; Tan, Loh Teng‐Hern

doi:10.36877/pmmb.a0000271

Cited by 21 publications

(20 citation statements)

References 70 publications

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“…That is why age must be considered when interpreting metabolomic research findings on cancer age-matched study participants [50,51]. In addition, many of the metabolite changes may be potentially modifiable with drugs, diet and nutritional supplementation [52,53] . Furthermore, metabolites in serum can originate from various sources, including the tumour itself, the host's physiological processes, and the gut microbiome [54] .…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Biomarkers and Metabolic Changes in the Serum of Breast Lump Patients Among Kelantanese Based on 1H NMR Metabolomics

Zulkefly,

Wan Azman,

Omar

et al. 2023

Prog Micobes Mol Biol

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This case-control study, conducted at the Hospital USM BestARi unit, aimed to identify the serum metabolic fingerprint among individuals with breast lumps and healthy controls, and to discover potential biomarkers. Serum samples from healthy controls, benign breast lump patients, and malignant breast lump patients were analyzed using proton nuclear magnetic resonance spectroscopy (1H NMR). A multivariate data analysis approach was employed, with the OPLS-DA and clustered heat map techniques effectively differentiating between the three groups. The study revealed significant metabolite variations across the groups and proposed D-glucose, glycerol, and glycine as potential biomarkers for breast cancer diagnosis. Metabolic pathways such as alanine, aspartate, glutamate metabolism, and glycine, serine, and threonine metabolism were implicated. The metabolomics approach coupled with multivariate analysis successfully identified key metabolites leading to group separation and suggested altered metabolic pathways. However, further research and integration with other ‘omics’ technologies are necessary for clinical translation.

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Section: Discussionmentioning

confidence: 99%

Identification of Potential Biomarkers and Metabolic Changes in the Serum of Breast Lump Patients Among Kelantanese Based on 1H NMR Metabolomics

Zulkefly,

Wan Azman,

Omar

et al. 2023

Prog Micobes Mol Biol

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“…Although microbiota exist in a ratio equivalent to that of human cells, they make up only 0.3% of the total body mass due to their tiny volume [ 52 , 54 , 55 ]. Nevertheless, the role of microbiota in human physiology and pathophysiology is immense and indisputable, to the extent that a portion of the scientific community has acknowledged the gut microbiota as an organ in its own right [ 56 , 57 , 58 , 59 , 60 , 61 ].…”

Section: Rudiments Of Probiotics: Human Gut Microbiota and Gut Dysbiosismentioning

confidence: 99%

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

Johnson

Letchumanan

Thum³

et al. 2023

Nutrients

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Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents a key domain of healthcare, which currently has limited, adverse-effect prone treatment options, and probiotics may hold the potential to be a novel, customizable treatment for depression. Clinical depression is a common, potentially debilitating condition that may be amenable to a precision psychiatry-based approach utilizing probiotics. Although our understanding has not yet reached a sufficient level, this could be a therapeutic approach that can be tailored for specific individuals with their own unique set of characteristics and health issues. Scientifically, the use of probiotics as a treatment for depression has a valid basis rooted in the microbiota-gut-brain axis (MGBA) mechanisms, which play a role in the pathophysiology of depression. In theory, probiotics appear to be ideal as adjunct therapeutics for major depressive disorder (MDD) and as stand-alone therapeutics for mild MDD and may potentially revolutionize the treatment of depressive disorders. Although there is a wide range of probiotics and an almost limitless range of therapeutic combinations, this review aims to narrow the focus to the most widely commercialized and studied strains, namely Lactobacillus and Bifidobacterium, and to bring together the arguments for their usage in patients with major depressive disorder (MDD). Clinicians, scientists, and industrialists are critical stakeholders in exploring this groundbreaking concept.

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“…It is well established that dietary factors could modulate an organism's gastrointestinal microbial community composition [8,96,164,[167][168][169][170][171][172][173][174] . Alteration to the gut microbiota composition of aquatic animals following probiotic supplementation has been well demonstrated [38,61,[175][176][177] .…”

Section: Increasing the Proportion Of Beneficial Bacteriamentioning

confidence: 99%

Probiotics: Comprehensive Exploration of the Growth Promotion Mechanisms in Shrimps

Goh¹,

Tan²,

Law³

et al. 2023

Prog Micobes Mol Biol

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As feed accounts for a significant proportion of a farm’s expenditure, animal nutrition is one of the key profit determinants. Attributed to the size-dependent market value, enhancing shrimps' growth is essential to maximize profit. Despite not being the best option, antibiotics are often used as growth-promoting agents in farming. Although this trend is less explicit in aquaculture, increasing production yield is paramount, especially when intensive aquafarming compromises animal growth and increases disease prevalence. However, the environmental and clinical pitfalls of indiscriminate antibiotic usage are surfacing. Fortunately, increasing evidence demonstrated probiotics as a safer, more sustainable, and environmental-friendly substitute for antibiotics. Nonetheless, most studies are observational, and the growth-promotion mechanisms of these agents are yet to be elucidated. In this light, this review aims to decipher the growth promotion mechanisms of probiotics in shrimps based on the primary works conducted. Evidently, probiotic treatment modulates the gut microbiome composition. The growth promotion effect of probiotics is partly mediated through the production of bioactive compounds such as short-chain fatty acids, vitamins, and polyamines. Besides, elevated digestive enzyme activities following the introduction of probiotics may help enhance digestibility and utilization. Histological changes at the hepatopancreas and intestine were evident. Furthermore, probiotics may reinforce the protective mechanisms in the gut and strengthen immune function. Treated shrimps demonstrate better appetite and exhibit superior metabolic and growth-related genes profile. Contrasting these recognized mechanisms with antibiotics helps construct the initial framework for designing high-quality probiotics for growth enhancement in farmed animals.

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Role of Garlic in Chronic Diseases: Focusing on Gut Microbiota Modulation

Cited by 21 publications

References 70 publications

Identification of Potential Biomarkers and Metabolic Changes in the Serum of Breast Lump Patients Among Kelantanese Based on 1H NMR Metabolomics

Identification of Potential Biomarkers and Metabolic Changes in the Serum of Breast Lump Patients Among Kelantanese Based on 1H NMR Metabolomics

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

Probiotics: Comprehensive Exploration of the Growth Promotion Mechanisms in Shrimps

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