Role of galectin‐3 in subclinical myocardial impairment in psoriasis

Kotwica, Tomasz; Relewicz, Joanna; Rojek, Aleksandra; Tupikowska-Marzec, Małgorzata; Kabaj, Maciej; Karolko, Bożena; Maj, Joanna; Bednarek-Tupikowska, Grażyna; Kosmala, Wojciech; Szepietowski, Jacek C.; Przewlocka‐Kosmala, M.

doi:10.1111/jdv.15211

Cited by 10 publications

(10 citation statements)

References 39 publications

(83 reference statements)

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“…Its decreased level in psoriatic keratinocytes has been shown to be a primary mechanism of cellular hyperproliferation, through the activation of the JNK pathway or the accumulation of neutrophils associated with S100A7-9 overexpression [ 98 ]. On the other hand, an increase in the levels of galectin-3 in the blood of psoriatic patients leads to inflammation and increased profibrotic activity [ 99 ]. However, the exact role of the downregulation of fibroblast galectin-3 in the development of psoriasis remains undefined.…”

Section: Discussionmentioning

confidence: 99%

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Gęgotek

Domingues

Wroński³

2020

IJMS

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The dermal fibroblasts are in constant contact with the cells of the immune system and skin epidermis. Therefore, they are essential for the development of lesions in psoriasis. The aim of this study was to assess the changes in the proteomic profile of fibroblasts in the dermis of psoriasis patients, and to discuss the most significant changes and their potential consequences. The proteomic results indicate that fibroblast dysfunction arises from the upregulation of proinflammatory factors and antioxidant proteins, as well as those involved in signal transduction and participating in proteolytic processes. Moreover, downregulated proteins in psoriatic fibroblasts are mainly responsible for the transcription/translation processes, glycolysis/ adenosine triphosphate synthesis and structural molecules. These changes can directly affect intercellular signaling and promote the hyperproliferation of epidermal cells. A better understanding of the metabolic effects of the proteomic changes observed could guide the development of new pharmacotherapies for psoriasis.

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Section: Discussionmentioning

confidence: 99%

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Gęgotek

Domingues

Wroński³

2020

IJMS

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“…These findings suggest that pro-inflammatory up-regulation in psoriasis may be responsible for the stimulation of myocardial fibrosis leading to LV functional derangements. This was confirmed by Kotwica et al (13) who added that a growing body of evidence from epidemiologic and pathophysiologic studies indicates that psoriasis should be considered not only as one of the inflammatory skin disorders, but also as a systemic disease with increased incidence of the wellestablished factors of cardio-vascular risk.…”

Section: Discussionmentioning

confidence: 83%

“…Previous studies revealed the association between the duration of psoriasis or its severity, as assessed by the PASI score, and the degree of the left ventricular systolic impairment (12) . Kotwica et al (13) confirmed this relationship only with respect to the latter. It is likely that the PASI score more accurately reflects the activity of pathophysiological derangements responsible for the myocardial function abnormalities than the duration of the disease, which sometimes is difficult to precisely determine.…”

Section: Discussionmentioning

confidence: 94%

“…The pro-fibrotic activity of Gal-3 includes stimulation of the proliferation and transformation of myocardial fibroblasts, with a subsequent increase in the formation and accumulation of collagen within the interstitium and perivascular space37. These changes may lead to left ventricular systolic and diastolic dysfunction, which is initially subclinical, but unless diagnosed and treated appropriately, it can progress in time to an overt heart failure (13) .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Subclinical Left Ventricular Systolic Dysfunction Using Two Dimensional Speckle Tracking Echocardiography in Patients with Psoriasis

Skokr

Elshahed

Nosir

et al. 2019

The Egyptian Journal of Hospital Medicine

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“…Patients with psoriasis have higher levels of Gal-3 than in healthy controls, leading to enhanced profibrotic activity. 52)…”

Section: Novel Biomarkersmentioning

confidence: 99%

Psoriasis and Cardiovascular Disease: A Narrative Review

2021

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Psoriasis is a chronic, autoimmune, and inflammatory disease that affects 2% of the world's population. In recent years, it has been demonstrated that psoriasis confers a 25% increase in relative risk of cardiovascular disease, independent of factors such as hyperlipidemia, smoking, and obesity. The objective of this review was to analyze and describe the association between psoriasis and cardiovascular disease. In this review, we describe the epidemiological association of psoriasis and cardiovascular disease, pathophysiology, mechanisms, and its association with the well-known cardiovascular risk calculators. In addition, we describe diagnostic tools, such as imaging techniques and novel biomarkers, that are useful in the evaluation of atherosclerotic cardiovascular disease. Finally, we present different systemic therapies that are used in patients with psoriasis and their effect on atherosclerotic cardiovascular disease. This article provides an overview of the current literature on psoriasis and cardiovascular risk, which can be useful for primary care physicians in their daily clinical practice.

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Role of galectin‐3 in subclinical myocardial impairment in psoriasis

Cited by 10 publications

References 39 publications

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Evaluation of Subclinical Left Ventricular Systolic Dysfunction Using Two Dimensional Speckle Tracking Echocardiography in Patients with Psoriasis

Psoriasis and Cardiovascular Disease: A Narrative Review

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