Role of galectin-3 in plasma as a predictive biomarker of outcome after acute intracerebral hemorrhage

Yan, Xin; Yu, Guofeng; Jie, Yuanqing; Fan, Xue‐Gong; Huang, Qiang; Dai, Weimin

doi:10.1016/j.jns.2016.06.071

Cited by 41 publications

(37 citation statements)

References 39 publications

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“…The only other study besides REGARDS that demonstrated an association of galectin‐3 with the risk of stroke evaluated patients who underwent carotid endarterectomy . Additionally, few studies have investigated the impact of galectin‐3 levels on outcomes after cerebrovascular accidents – higher levels acutely were associated with worse outcomes in intracranial hemorrhage as well as subarachnoid hemorrhage . A recent study suggested no impact of galectin‐3 levels on occurrence of acute neurological decline, 3‐month mortality or 3‐month clinical outcome after ischaemic stroke, but the sample size was very small with 26 stroke patients and 10 controls .…”

Section: Discussionmentioning

confidence: 99%

Galectin‐3 and risk of ischaemic stroke: Reasons for Geographic and Racial Differences in Stroke cohort

Arora

Agarwal

Venkatraman

et al. 2017

Euro J of Neurology

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Section: Discussionmentioning

confidence: 99%

Galectin‐3 and risk of ischaemic stroke: Reasons for Geographic and Racial Differences in Stroke cohort

Arora

Agarwal

Venkatraman

et al. 2017

Euro J of Neurology

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“…Heart disease acute heart failure plasma level combination with natriuretic peptide [62] acute heart failure plasma level promising prognostic marker [63] chronic heart failure plasma level useful in HF patients with preserved LVEF [64] chronic heart failure myocardial and plasma level not associated with histology [65] acute myocardial infarction serum level no definite relationship with ventricular remodeling [66] Nervous system diseases myelin degeneration tissues activation of the phagocytosis of degenerated myelin [42] intracerebral hemorrhage plasma level prognostic predictor [67] subarachnoid hemorrhage plasma level prognostic predictor [68] global brain ischemia cerebrospinal fluid prognostic marker and inflammatory mediator [69] Renal disease CKD plasma level associated with progression of CKD [25] SLE nephritis serum and biopsy specimens associated with SLE patients, particularly in SLE nephritis [70] Liver disease liver fibrosis serum Gal-3 related binding protein assessing liver fibrosis [71] Connective tissue diseases rheumatoid arthritis serum level increased in early rheumatoid arthritis [72] SLE serum anti-Gal-3 antibody a key role in SLE skin lesions [73] systemic sclerosis serum level predictor of mortality [74] Neoplasms colorectal cancer serum and tissues related to tumor progression [52] breast cancer human cell lines important factor for treatment [75] non-small cell lung cancer tumor expression promotion of invasion and metastasis [76] lung and prostate cancers tumor expression therapeutic target of tumor immunity [77] cervical cancer tumor expression targets of multifunctional cancer treatment [78] thyroid cancer tumor expression diagnostic marker [79]…”

Section: Diseasesmentioning

confidence: 99%

Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases

et al. 2020

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Galectin-3 is a β-galactoside-binding lectin which is important in numerous biological activities in various organs, including cell proliferation, apoptotic regulation, inflammation, fibrosis, and host defense. Galectin-3 is predominantly located in the cytoplasm and expressed on the cell surface, and then often secreted into biological fluids, like serum and urine. It is also released from injured cells and inflammatory cells under various pathological conditions. Many studies have revealed that galectin-3 plays an important role as a diagnostic or prognostic biomarker for certain types of heart disease, kidney disease, viral infection, autoimmune disease, neurodegenerative disorders, and tumor formation. In particular, it has been recognized that galectin-3 is extremely useful for detecting many of these diseases in their early stages. The purpose of this article is to review and summarize the recent literature focusing on the biomarker characteristics and long-term outcome predictions of galectin-3, in not only patients with various types of diseases, but associated animal models.

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“…Gal-3 is distributed in many tissues, such as the heart, lungs, blood, kidneys, and digestive tract. Monocytes, macrophages, dendritic cells, and epithelial and endothelial cells exhibit Gal-3 expression [54,55,56,57]. After stimulation with pathogens or LPS, Gal-3 can be detected both intracellularly and extracellularly [58,59].…”

Section: Discussionmentioning

confidence: 99%

Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model

Wang

et al. 2018

IJMS

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Hyperbaric oxygen (HBO) treatment has been proven to decrease neuroinflammation in rats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effects of HBO treatment on burn-induced neuroinflammation in rats. Thirty-six adult male Sprague-Dawley (SD) rats were randomly assigned to the following six groups (n = 6 per group): (1) sham burn with sham HBO treatment; (2) sham burn with HBO treatment; (3) burn with one-week sham HBO treatment; (4) burn with two-week sham HBO treatment; (5) burn with one-week HBO treatment; and (6) burn with two-week HBO treatment. SD rats that received third-degree burn injury were used as a full-thickness burn injury model. Subsequently, we analyzed the expression of proteins involved in the galectin-3 (Gal-3)-dependent Toll-like receptor-4 (TLR-4) pathway through enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC) analysis, and Western blotting. A behavior test was also conducted, which revealed that HBO treatment significantly suppressed mechanical hypersensitivity in the burn with HBO treatment group compared to the burn with sham HBO treatment group (p < 0.05). ELISA results showed that tumor necrosis factor α (TNF-α) and interleukin 1 beta (IL-1β) levels in the dorsal horn of the spinal cord and the skin significantly decreased in the burn with HBO treatment group compared with the burn with sham HBO treatment group (p < 0.05). Western blotting results demonstrated that HBO treatment significantly reduced the expression of Gal-3 and TLR-4 in the dorsal horn of the spinal cord in the burn with HBO treatment group compared with the burn with sham HBO treatment group (p < 0.05). IHC analysis showed that the expression of Gal-3, TLR-4, CD68 and CD45 in the dorsal horn of the spinal cord was significantly lower in the burn with HBO treatment group than in the burn with sham HBO treatment group (p < 0.05), and the expression of CD68 and macrophage migration inhibitory factor (MIF) in the right hind paw skin was significantly lower. The expression of vimentin and fibroblast growth factor in the right hind paw skin was significantly higher after HBO treatment (p < 0.05). This study proved that early HBO treatment relieves neuropathic pain, inhibits the Gal-3-dependent TLR-4 pathway, and suppresses microglia and macrophage activation in a rat model.

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Role of galectin-3 in plasma as a predictive biomarker of outcome after acute intracerebral hemorrhage

Cited by 41 publications

References 39 publications

Galectin‐3 and risk of ischaemic stroke: Reasons for Geographic and Racial Differences in Stroke cohort

Galectin‐3 and risk of ischaemic stroke: Reasons for Geographic and Racial Differences in Stroke cohort

Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases

Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model

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