2008
DOI: 10.4049/jimmunol.180.4.2466
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Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae

Abstract: Pneumonia can be caused by a variety of pathogens, among which Streptococcus pneumoniae causes one of the most common forms of community-acquired pneumonia. Depending on the invading pathogen, the elements of the immune response triggered will vary. For most pathogens, such as Escherichia coli, neutrophil recruitment involves a well-described family of adhesion molecules, β2-integrins. In the case of streptococcal pneumonia, however, neutrophil recruitment occurs mainly through a β2-integrin-independent pathwa… Show more

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Cited by 103 publications
(131 citation statements)
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References 78 publications
(103 reference statements)
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“…Gal-3 also promotes neutrophil adhesion to endothelial cells in vitro and may play an important role in beta-2 integrin-independent neutrophil extravasation in vivo (Sato et al 2002). These results, along with a decreased cellular infiltrate observed in numerous in vivo models of inflammation performed in Gal-3 null mice, provide evidence for a role for this galectin in mediating leukocyte recruitment during an inflammatory response (Colnot et al 1998a,b, Bernardes et al 2006, Nieminen et al 2008 With regards to apoptosis, Gal-3 appears to function differently in relation to its localisation, i.e. whether it is inside or outside the cell.…”
Section: Actions Of Exogenous Galectin-3mentioning
confidence: 48%
“…Gal-3 also promotes neutrophil adhesion to endothelial cells in vitro and may play an important role in beta-2 integrin-independent neutrophil extravasation in vivo (Sato et al 2002). These results, along with a decreased cellular infiltrate observed in numerous in vivo models of inflammation performed in Gal-3 null mice, provide evidence for a role for this galectin in mediating leukocyte recruitment during an inflammatory response (Colnot et al 1998a,b, Bernardes et al 2006, Nieminen et al 2008 With regards to apoptosis, Gal-3 appears to function differently in relation to its localisation, i.e. whether it is inside or outside the cell.…”
Section: Actions Of Exogenous Galectin-3mentioning
confidence: 48%
“…However, 5 days postinfection the intensity of the inflammatory response was even higher in the liver of gal3 À/À mice. Recently, Nieminen and colleagues reported [36] that the neutrophil recruitment was impaired in Streptococcus pneumoniae-infected gal3 À/À mice, whereas a larger number of neutrophils were detected in the BAL fluids of Escherichia coli-infected gal3 À/À mice, when compared with gal3 1/1 mice. In our study, the enhanced inflammatory response that occurred at later times postinfection did not corroborate the previously reported proinflammatory role of galectin-3 and may reflect a differential role of galectin-3 on the various cell types that compose the granuloma.…”
Section: Discussionmentioning
confidence: 99%
“…Galectin-3 also modulates cytokine responses to pathogen (Rabinovich and Toscano, 2009). For innate immune cells, galectin-3 is suggested to be involved in neutrophil migration in streptococcal pneumonia (Sato et al, 2002;Nieminen et al, 2008). Once migrated, neutrophils are also activated by galectin-3, which results in degranulation of various layers of microbicidal factors (Yamaoka et al, 1995;Karlsson et al, 1998;Nieminen et al, 2005Nieminen et al, , 2007.…”
Section: Discussionmentioning
confidence: 99%