Role of food-derived antioxidants against cisplatin induced-nephrotoxicity

Gómez-Sierra, Tania; Eugenio‐Pérez, Dianelena; Sánchez-Chinchillas, Argelia; Pedraza‐Chaverrí, José

doi:10.1016/j.fct.2018.07.018

Cited by 74 publications

(53 citation statements)

References 164 publications

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“…There are undeniable shreds of evidence that oxidative stress plays a pivotal role in the pathogenesis of CDDP-induced nephrotoxicity. It has been reported that the generation of reactive oxygen species (ROS) induced by CDDP promotes cellular damage [ 59 , 60 ], apoptosis, and inflammation [ 61 ]. In this study, the CDDP-injected group showed serious oxidative stress in renal tissues indicated by SOD reduction and a marked increase in H 2 O 2 as well as lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Mahran

Hassan

2020

Oxidative Medicine and Cellular Longevity

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Background. Cisplatin (cis-diaminedichloroplatinum, CDDP) is a broad-spectrum antineoplastic agent. However, CDDP has been blamed for its nephrotoxicity, which is the main dose-limiting adverse effect. Ganoderma lucidum (GL), a medicinal mushroom, has antioxidant and inflammatory activities. Therefore, this study is aimed at finding out the potential nephroprotection of GL against CDDP-induced nephrotoxicity in rats and the possible molecular mechanisms including the EGFR downstream signaling, apoptosis, and autophagy. Methods. Rats were given GL (500 mg/kg) for 10 days and a single injection of CDDP (12 mg/kg, i.p). Results. Nephrotoxicity was evidenced by a significant increase in renal indices and oxidative stress markers. Additionally, CDDP showed a plethora of inflammatory and apoptotic responses as evidenced by a profound increase of HMGB-1, NF-κB, and caspase-3 expressions, whereas administration of GL significantly improved all these indices as well as the histopathological insults. Renal expression of EGFR showed a similar trend after GL administration. Furthermore, activation of autophagy protein, LC3 II, was found to be involved in GL-mediated nephroprotection correlated with the downregulation of apoptotic signaling, caspase-3 and terminal deoxynucleotidyl transferase (TDT) renal expressions. Conclusion. These results suggest that GL might have improved CDDP-induced nephrotoxicity through antioxidant, anti-inflammatory, and autophagy-mediated apoptosis mechanisms and that inhibition of EGFR signaling might be involved in nephroprotection.

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Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Mahran

Hassan

2020

Oxidative Medicine and Cellular Longevity

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“…Since ancient times it has been used along other curcuminoids extracted from turmeric in traditional medicine due to its beneficial influence on human health. Curcumin shows anti-oxidant ( 1 ), anti-inflammatory ( 2 ), anti-microbial ( 3 ) and anti-tumor ( 4 ), nephro-protective ( 5 ) and anti-diabetic ( 6 ) activities. Importantly, curcumin is safe even at high doses ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin

2019

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Purpose Study on curcumin dissolved in natural deep eutectic solvents (NADES) was aimed at exploiting their beneficial properties as drug carriers. Methods The concentration of dissolved curcumin in NADES was measured. Simulated gastrointestinal fluids were used to determine the concentration of curcumin and quantum chemistry computations were performed for clarifying the origin of curcumin solubility enhancement in NADES. Results NADES comprising choline chloride and glycerol had the highest potential for curcumin dissolution. This system was also successfully applied as an extraction medium for obtaining curcuminoids from natural sources, as well as an effective stabilizer preventing curcumin degradation from sunlight. The solubility of curcumin in simulated gastrointestinal fluids revealed that the significant increase of bioavailability takes place in the small intestinal fluid. Conclusions Suspension of curcumin in NADES offers beneficial properties of this new liquid drug formulation starting from excreting from natural sources, through safe storage and ending on the final administration route. Therefore, there is a possibility of using a one-step process with this medium. The performed quantum chemistry computations clearly indicated the origin of the enhanced solubility of curcumin in NADES in the presence of intestinal fluids. Direct intermolecular contacts leading to hetero-molecular pairs with choline chloride and glycerol are responsible for elevating the bulk concentration of curcumin. Choline chloride plays a dominant role in the system and the complexes formed with curcumin are the most stable among all possible homo- and hetero-molecular pairs that can be found in NADES-curcumin systems.

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“…The mechanism of CP nephrotoxicity has been studied for the last forty years and binding to multiple targets such as deoxyribonucleic acid or glutathione (GSH) have been identified. Also, mechanisms such as oxidative stress, inflammation, mitochondrial dysfunction, and ER stress have been associated to kidney damage [ 19 , 20 , 21 , 22 , 24 ], and although the contribution of each pathway is not exactly known, oxidative stress plays a key role [ 19 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…Based on the knowledge of the main pathways involved in CP-induced nephrotoxicity, such as oxidative stress [ 19 , 21 , 22 , 25 , 54 ], apoptosis [ 20 , 21 , 22 , 25 ], mitochondrial dysfunction [ 20 , 21 , 22 , 25 ], kinases activation [ 21 , 22 , 54 ], and ER stress [ 21 , 24 , 55 ], treatments with natural compounds have been implemented to prevent CP-induced nephrotoxicity [ 20 , 21 , 24 , 25 , 56 , 57 , 58 ]. However, it is necessary to explore more compounds and other targets less studied, such as ER stress, due to the complexity of cisplatin toxicity.…”

Section: Introductionmentioning

confidence: 99%

Isoliquiritigenin Pretreatment Induces Endoplasmic Reticulum Stress-Mediated Hormesis and Attenuates Cisplatin-Induced Oxidative Stress and Damage in LLC-PK1 Cells

et al. 2020

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Isoliquiritigenin (IsoLQ) is a flavonoid with antioxidant properties and inducer of endoplasmic reticulum (ER) stress. In vitro and in vivo studies show that ER stress-mediated hormesis is cytoprotective; therefore, natural antioxidants and ER stress inducers have been used to prevent renal injury. Oxidative stress and ER stress are some of the mechanisms of damage involved in cisplatin (CP)-induced nephrotoxicity. This study aims to explore whether IsoLQ pretreatment induces ER stress and produces hormesis to protect against CP-induced nephrotoxicity in Lilly Laboratories Cell-Porcine Kidney 1 (LLC-PK1) cells. During the first stage of this study, both IsoLQ protective concentration and pretreatment time against CP-induced toxicity were determined by cell viability. At the second stage, the effect of IsoLQ pretreatment on cell viability, ER stress, and oxidative stress were evaluated. IsoLQ pretreatment in CP-treated cells induces expression of glucose-related proteins 78 and 94 kDa (GRP78 and GRP94, respectively), attenuates CP-induced cell death, decreases reactive oxygen species (ROS) production, and prevents the decrease in glutathione/glutathione disulfide (GSH/GSSG) ratio, free thiols levels, and glutathione reductase (GR) activity. These data suggest that IsoLQ pretreatment has a moderately protective effect on CP-induced toxicity in LLC-PK1 cells, through ER stress-mediated hormesis, as well as by the antioxidant properties of IsoLQ.

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Role of food-derived antioxidants against cisplatin induced-nephrotoxicity

Cited by 74 publications

References 164 publications

Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin

Isoliquiritigenin Pretreatment Induces Endoplasmic Reticulum Stress-Mediated Hormesis and Attenuates Cisplatin-Induced Oxidative Stress and Damage in LLC-PK1 Cells

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