Role of foetal MRI in the evaluation of ischaemic-haemorrhagic lesions of the foetal brain

Manganaro, Lucia; Bernardo, Silvia; Barbera, Laura La; Noia, G.; Masini, Lucia; Tomei, Alessandra; Fierro, Francesca; Vinci, Valeria; Sollazzo, Paolo; Silvestri, Evelina; Giancotti, Antonella; Marini, Mario

doi:10.1515/jpm-2011-0182

Cited by 35 publications

(46 citation statements)

References 11 publications

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“…This imaging modality has been widely used to assess central nervous system diseases in children and adults [1,2,3,4]. Currently, fetal brain DWI has focused on quantitative studies about normal fetal brain development and is becoming a useful method to assess fetal brain structure in pathological conditions [5,6,7,8,9,10,11]. However, it is still not clear whether the ADC value could be useful to quantitatively assess changes in brain development due to pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Apparent Diffusion Coefficient of Normal Fetal Brain Development from Gestational Age Week 24 Up to Term Age: A Preliminary Study

Han

Huang²,

Sun

et al. 2014

Fetal Diagn Ther

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Objectives: This study was designed to investigate the feasibility of apparent diffusion coefficient (ADC) values in evaluating normal fetal brain development from gestational week 24 up to term age. Methods: Diffusion-weighted imaging (DWI) was performed on 40 normal fetuses (with normal results on sonography and normal fetal MRI results), with two b-values of 0 and 600 s/mm² in the three (x, y, z) orthogonal axes. Ten regions of interest (ROIs) were manually placed symmetrically in the bilateral frontal white matter (FWM), occipital white matter (OWM), thalamus (THAL), basal ganglia (BG), and cerebellar hemispheres (CH). ADC values of the ten ROIs in all subjects were measured by two radiologists independently. One-way ANOVA was used to calculate the differences among the five regions in the fetal brain and linear regression analysis was used to evaluate the correlation between ADC values and gestational age (GA). p < 0.05 was considered significantly different. Results: Mean GA was 31.3 ± 3.9 (range 24-41) weeks. The overall mean ADC values (×10^-6 mm²/s) of the fetuses were 1,800 ± 214 (FWM), 1,400 ± 100 (BG), 1,300 ± 126 (THAL), 1,700 ± 133 (OWM) and 1,400 ± 155 (CH), respectively. The ADC value of BG was not significantly different from those of THAL and CH, while the other four ROIs had significant differences with each other. The ADC values of BG, THAL, OWM and CH had strong negative correlations with increasing GA (R were -0.568, -0.716, -0.830 and -0.700, respectively, all p < 0.01), OWM declined fastest with GA, followed by CH and THAL, the slowest being BG. The ADC value of FWM had no significant change with GA (p = 0.366). Conclusions: The measurement of ADC values is feasible to evaluate fetal brain development with high reliability and reproducibility.

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Section: Introductionmentioning

confidence: 99%

Assessment of Apparent Diffusion Coefficient of Normal Fetal Brain Development from Gestational Age Week 24 Up to Term Age: A Preliminary Study

Han

Huang²,

Sun

et al. 2014

Fetal Diagn Ther

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“…Cerebellar hemorrhages can be a complication of cytomegalovirus infection, or be caused by bleeding from a congenital vascular defect such as a cavernous haemangioma, or by a trauma, and may be related to a haemorrhagic transformation of an infarction, but in most cases the cause remains obscure (2,3,8). Unilateral cerebellar hypoplasia has also been reported in association with some syndromes such as Moebius syndrome or Goldenhar syndrome, which also, likely result from a prenatal destructive lesion, probably ischaemic (2,3).…”

Section: Discussionmentioning

confidence: 99%

Fetal MRI and antenatal diagnosis of unilateral cerebellar hypoplasia

Mhabrech

Zrig

Hafsa

2015

The Egyptian Journal of Radiology and Nuclear Medicine

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Focal cerebellar hypoplasia is restricted to one cerebellar hemisphere or to the vermis. Prenatal diagnosis of unilateral cerebellar hypoplasia is possible by the use of ultrasound and MRI. Familiarity with the prenatal MRI findings is essential to recognize cerebellar pathologies accurately and prospectively. We present US and MRI findings in a fetus with cerebellar malformation at 20 weeks gestation. The goal of our case report is to present the fetal MRI findings of unilateral cerebellar hypoplasia, to discuss the value of fetal MRI in the early diagnoses of this malformation and to summarize the current main stream literature concerning the etiology.

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“…Fetal MRI is a valuable exploration, complementary to prenatal US. By the higher resolution and contrast, the ample field of examination and the ability to simultaneously explore both sides of the fetus, fetal MRI can sometimes be more accurate than US in fetal morphological assessment [8,9]. Prenatal diagnosis of skeletal dysplasia can sometimes be very difficult due to overlapping symptoms or to very subtle differences between different pathological subtypes and due to late onset of these conditions.…”

Section: (27)mentioning

confidence: 99%

Ultrasound and MRI comprehensive approach in prenatal diagnosis of fetal osteochondrodysplasias. Cases series.

et al. 2017

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Aim: To present the systematic ultrasonographic assessment in fetal osteochondrodysplasias and to evaluate the fetal MRI intake, as a complementary exploration to US, in the prenatal diagnosis and perinatal prognosis of fetal nonlethal osteochondrodysplasias. Material and methods: In this tertiary multicentre study were included 37 cases diagnosed prenatally with various entities in the category of nonlethal fetal osteochondrodysplasias. The initial diagnosis was carried out by the routine or detailed ultrasound examination. Fetal MRI was accomplished for selected cases. Results: Nonlethal skeletal dysplasia was suspected and then diagnosed after 17 gestational weeks. The suspicion of osteochondrodysplasia as a reference diagnosis element has required systematic and thorough ultrasound examination. Fetal MRI is a valuable exploration, complementary to prenatal ultrasound bringing in very useful details for the diagnosis of osteochondrodysplasias. The global diagnosis of skeletal dysplasia depends to a great extent on the genetic or biochemical abnormality that causes them. Conclusions: US is always the fundamental screening exploration for fetal assessment in nonlethal osteochondrodysplasias. The details brought by the fetal MRI are useful, and the exploration is harmless for the fetus and the mother. Certain diagnosis cannot be accurate and complete without the contribution of genetics, maternal and fetal medicine, obstetrics or radiology.

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Role of foetal MRI in the evaluation of ischaemic-haemorrhagic lesions of the foetal brain

Abstract: Foetal MRI is an additional imaging modality in the diagnosis of cerebral ischemic-haemorrhagic lesions, and it is useful in providing further information on the extension of the parenchymal injury and associated abnormalities, thus improving delivery management.

Cited by 35 publications

References 11 publications

Assessment of Apparent Diffusion Coefficient of Normal Fetal Brain Development from Gestational Age Week 24 Up to Term Age: A Preliminary Study

Assessment of Apparent Diffusion Coefficient of Normal Fetal Brain Development from Gestational Age Week 24 Up to Term Age: A Preliminary Study

Fetal MRI and antenatal diagnosis of unilateral cerebellar hypoplasia

Ultrasound and MRI comprehensive approach in prenatal diagnosis of fetal osteochondrodysplasias. Cases series.

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