Role of flavonoids on oxidative stress and mineral contents in the retinoic acid-induced bone loss model of rat

Oršolić, Nada; Goluža, Eleonora; Đikić, Domagoj; Lisičić, Duje; Sašilo, Kristijan; Rođak, Edi; Jeleč, Željko; Lazarus, Maja; Orct, Tatjana

doi:10.1007/s00394-013-0622-7

Cited by 54 publications

(64 citation statements)

References 37 publications

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“…Orsolic et al (2014) reported the inverse results in that the rats’ body weight decreased after treatment with 80 mg/kg body weight retinoic acid and most rats died before the end of the experiment [2]. Nonetheless, no mortality and weight loss were observed in this study by retinoic acid treatment at the same dose.…”

Section: Resultsmentioning

confidence: 50%

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Desalted Duck Egg White Peptides Promote Calcium Uptake and Modulate Bone Formation in the Retinoic Acid-Induced Bone Loss Rat and Caco-2 Cell Model

et al. 2017

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Desalted duck egg white peptides (DPs) have been proven to promote calcium uptake in Caco-2 cells and rats treated with a calcium-deficient diet. The retinoic acid-induced bone loss model was used to evaluate the effect of DPs on calcium absorption and bone formation. Three-month-old Wistar female rats were treated with 0.9% saline, DPs (800 mg/kg), or alendronate (5 mg/kg) for three weeks immediately after retinoic acid treatment (80 mg/kg) once daily for two weeks. The model group was significantly higher in serum bone alkaline phosphatase than the other three groups (p < 0.05), but lower in calcium absorption rate, serum osteocalcin, bone weight index, bone calcium content, bone mineral density, and bone max load. After treatment with DPs or alendronate, the absorption rate increased and some serum and bone indices recovered. The morphology results indicated bone tissue form were ameliorated and numbers of osteoclasts decreased after supplementation with DPs or alendronate. The in vitro study showed that the transient receptor potential vanilloid 6 (TRPV6) calcium channel was the main transport pathway of both DPs and Val-Ser-Glu-Glu peptitde (VSEE), which was identified from DPs. Our results indicated that DPs could be a promising alternative to current therapeutic agents for bone loss because of the promotion of calcium uptake and regulation of bone formation.

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Section: Resultsmentioning

confidence: 50%

“…There is a negative imbalance between bone formation and bone resorption resulting in bone loss and the etiology can be multifactorial, with contributions from diet and lifestyle, genetics like sex and ethnicity, and other medical conditions [2]. Postmenopausal osteoporosis accounts for a large proportion of osteoporosis in patients.…”

Section: Introductionmentioning

confidence: 99%

Desalted Duck Egg White Peptides Promote Calcium Uptake and Modulate Bone Formation in the Retinoic Acid-Induced Bone Loss Rat and Caco-2 Cell Model

et al. 2017

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“…Further studies also showed that retinoic acid causes constant decrease of BMD in a short period of 1-3 weeks [20]. All these findings demonstrated that shortterm effects of retinoic acid could act as an appropriate revulsive of osteoporosis [22].…”

Section: Introductionmentioning

confidence: 96%

Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats

Zhao

Niu

et al. 2015

Ir J Med Sci

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“…A flavonoid rich diet is reported to induce the expression of antioxidative enzymes in various cell types [35–38]. However, this induction of the expression of antioxidative enzymes can only be reached, when flavonoids are consumed at high doses over a long period of time.…”

Section: Discussionmentioning

confidence: 99%

Increased Oxidative Stress Response in Granulocytes from Older Patients with a Hip Fracture May Account for Slow Regeneration

Wang

Ehnert

Ihle

et al. 2014

Oxidative Medicine and Cellular Longevity

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Proximal femur fracture, a typical fracture of the elderly, is often associated with morbidity, reduced quality of life, impaired physical function and increased mortality. There exists evidence that responses of the hematopoietic microenvironment to fractures change with age. Therefore, we investigated oxidative stress markers and oxidative stress-related MAPK activation in granulocytes from the young and the elderly with and without fractured long bones. Lipid peroxidation levels were increased in the elderly controls and patients. Aged granulocytes were more sensitive towards oxidative stress induced damage than young granulocytes. This might be due to the basally increased expression of SOD-1 in the elderly, which was not further induced by fractures, as observed in young patients. This might be caused by an altered MAPK activation. In aged granulocytes basal p38 and JNK activities were increased and basal ERK1/2 activity was decreased. Following fracture, JNK activity decreased, while ERK1/2 and p38 activities increased in both age groups. Control experiments with HL60 cells revealed that the observed p38 activation depends strongly on age. Summarizing, we observed age-dependent changes in the oxidative stress response system of granulocytes after fractures, for example, altered MAPK activation and SOD-1 expression. This makes aged granulocytes vulnerable to the stress stimuli of the fracture and following surgery.

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Role of flavonoids on oxidative stress and mineral contents in the retinoic acid-induced bone loss model of rat

Abstract: These results suggest that the dietary flavonoids could reduce retinoic acid-induced oxidative stress and bone loss and that flavonoids may be useful therapeutics for prevention of skeletal diseases.

Cited by 54 publications

References 37 publications

Desalted Duck Egg White Peptides Promote Calcium Uptake and Modulate Bone Formation in the Retinoic Acid-Induced Bone Loss Rat and Caco-2 Cell Model

Desalted Duck Egg White Peptides Promote Calcium Uptake and Modulate Bone Formation in the Retinoic Acid-Induced Bone Loss Rat and Caco-2 Cell Model

Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats

Increased Oxidative Stress Response in Granulocytes from Older Patients with a Hip Fracture May Account for Slow Regeneration

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