Role of Flavonoids in the Treatment of Iron Overload

Wang, Xiaomin; Li, Ye; Li, Han; Li, Jie; Liu, Cun; Sun, Changgang

doi:10.3389/fcell.2021.685364

Cited by 46 publications

(45 citation statements)

References 74 publications

(87 reference statements)

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“…Furthermore, the Fe-catechin coordination complexes did not cause oxidative stress or toxic effects due to a possible iron-overload [25,81]. This exploration supports the rationality for adjuvant treatment of iron-overload disease by some iron-chelating agents [81].…”

Section: Discussionsupporting

confidence: 63%

“…The Fe-catechin coordination complexes showed no toxicity to crustacean species Artemia salina L., which is sensitive to oxidative stress [49,78,79] and often used for ecotoxicological investigations [80]. Furthermore, the Fe-catechin coordination complexes did not cause oxidative stress or toxic effects due to a possible iron-overload [25,81]. This exploration supports the rationality for adjuvant treatment of iron-overload disease by some iron-chelating agents [81].…”

Section: Discussionsupporting

confidence: 63%

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(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

Kubicová

Bachmann

Weckwerth

et al. 2022

Cells

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Catechin is an extensively investigated plant flavan-3-ol with a beneficial impact on human health that is often associated with antioxidant activities and iron coordination complex formation. The aim of this study was to explore these properties with FeII and FeIII using a combination of nanoelectrospray-mass spectrometry, differential pulse voltammetry, site-specific deoxyribose degradation assay, FeII autoxidation assay, and brine shrimp mortality assay. Catechin primarily favored coordination complex formation with Fe ions of the stoichiometry catechin:Fe in the ratio of 1:1 or 2:1. In the detected Fe–catechin coordination complexes, FeII prevailed. Differential pulse voltammetry, the site-specific deoxyribose degradation, and FeII autoxidation assays proved that coordination complex formation affected catechin’s antioxidant effects. In situ formed Fe–catechin coordination complexes showed no toxic activities in the brine shrimp mortality assay. In summary, catechin has properties for the possible treatment of pathological processes associated with ageing and degeneration, such as Alzheimer’s and Parkinson’s diseases.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionsupporting

confidence: 63%

(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

Kubicová

Bachmann

Weckwerth

et al. 2022

Cells

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“…The prooxidant activity is exerted by the chelation of iron (II) and the reduction of iron (III), both involved as a catalyst in the Fenton reaction. Indeed, the chelation or reduction of iron ions prevents the conversion of hydrogen peroxide to hydroxyl radicals [ 49 ]. The IC50 values of the DPPH inhibition were 0.17 ± 0.02 and 0.17 ± 0.01 mg of biomass for LA and LI, respectively.…”

Section: Resultsmentioning

confidence: 99%

Characterization and Valorization of the Agricultural Waste Obtained from Lavandula Steam Distillation for Its Reuse in the Food and Pharmaceutical Fields

et al. 2022

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The main focus of the current research was the characterization of the by-products from the steam distillation of Lavandula angustifolia Mill. (LA) and Lavandula x intermedia Emeric ex Loisel (LI) aerial parts, as they are important sources of bioactive compounds suitable for several applications in the food, cosmetic, and pharmaceutical industries. The oil-exhausted biomasses were extracted and the total polyphenol and flavonoid contents were, respectively, 19.22 ± 4.16 and 1.56 ± 0.21 mg/g for LA extract and 17.06 ± 3.31 and 1.41 ± 0.10 mg/g for LI extract. The qualitative analysis by liquid chromatography-electrospray tandem mass spectrometry (HPLC-ESI-MS) revealed that both the extracts were rich in phenolic acids and glycosylated flavonoids. The extracts exhibited radical scavenging, chelating, reducing activities, and inhibitory capacities on acetylcholinesterase and tyrosinase. The IC50 values against acetylcholinesterase and tyrosinase were, respectively, 5.35 ± 0.47 and 5.26 ± 0.02 mg/mL for LA, and 6.67 ± 0.12 and 6.56 ± 0.16 mg/mL for LI extracts. In conclusion, the oil-exhausted biomasses demonstrated to represent important sources of bioactive compounds, suitable for several applications in the food, cosmetic, and pharmaceutical industries.

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“…We treated group 3 with cassia senna from day 16 to 30 and the iron levels declined to the control values in serum, kidney, liver, and heart (p-value less than 0.05). This herb was also used by Wang et al to reverse the iron-induced hepatic damage, he reversed CdCl2-induced hepatotoxicity by decreasing levels of ALT, and AST 16 . Some other herbs like Medicago sativa and Allium porrum were also used previously to reduce the iron concentration in serum, liver, and heart to significant levels 17 .…”

Section: Discussionmentioning

confidence: 99%

Comparative Effects of Nigella Sativa and Cassia Senna in Iron Overloaded Mice

Naeem¹,

Azhar²,

Shadab³

et al. 2022

PJMHS

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Background: Iron overload-related complications are the main concern in patients who must often receive blood transfusions. The only way to treat iron overload in these patients is by chelating agents. Owing to the high cost and adverse effects of chelating agents use of naturally present chelators is under study. Aim: To compare the protective effects of two commonly used herbs Nigella Sativa and Cassia Senna in iron-overloaded mice. Study Design: Experimental randomized controlled trial. Setting: Zoology department of Govt College University Lahore during six months period. Method: A total of forty-eight mice were divided into four groups (n = 12). Group one was normal to control while group 2, 3, and 4 were overloaded with iron by intravenous injection of iron dextran (0.1 ml/kg body weight) daily for fifteen days. After 15 days iron overload was confirmed by blood testing. For additional 15 days, group three mice were provided with Cassia Senna (100 mg/Kg body weight) while group four mice were permitted to feed on Nigella sativa (200 mg/Kg body weight). Animals were sacrificed on day 32 and organs were preserved to check the iron levels. Blood sampling was done on days 0, 15, and 31 to analyze serum iron levels. Results: The protective effect of Nigella Sativa was more marked than cassia senna in iron 0verloaded mice. Conclusion: The addition of Nigella Sativa instead of cassia senna in iron-laden patients as an adjunct therapy can be more beneficial in preventing the damaging effects of iron overload. Keywords: iron overload, Nigella Sativa, Cassia Senna

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Role of Flavonoids in the Treatment of Iron Overload

Cited by 46 publications

References 74 publications

(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

Characterization and Valorization of the Agricultural Waste Obtained from Lavandula Steam Distillation for Its Reuse in the Food and Pharmaceutical Fields

Comparative Effects of Nigella Sativa and Cassia Senna in Iron Overloaded Mice

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