Role of FK506-Binding Protein 12 in Development of the Chick Embryonic Heart

Okihara, Koji; Koide, Masafumi; Nagata, Kazuya; Iio, Akio; Yazawa, Shogo; Ono, Tamao; Yamada, Yoshiji; Tuan, Rocky S.; Yokota, Mitsuhiro

doi:10.1006/bbrc.2001.4799

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…2008). FKBP1A and cFKBP/SMAP are also critical for heart development (Obata et al. 2001), and for smooth muscle differentiation in the chick embryo (Fukuda et al.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, FKBP8 (known as FKBP38) is involved in the development of mouse embryo and is required for neuroectodermal organization during neural tube formation (Bulgakov et al 2004;Cho et al 2008;Shirane et al 2008;Wong et al 2008). FKBP1A and cFKBP ⁄ SMAP are also critical for heart development (Obata et al 2001), and for smooth muscle differentiation in the chick embryo (Fukuda et al 1998), respectively. Furthermore, injection of Xenopus orthologue of mammalian FKBP1A (xFKBP1A) mRNA into dorsal blastomeres of 4-cell stage Xenopus embryos induces a secondary axis (Nishinakamura et al 1997).…”

Section: Introductionmentioning

confidence: 99%

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Peptidyl‐prolyl cis‐trans isomerase xFKBP1B induces ectopic secondary axis and is involved in eye formation during Xenopus embryogenesis

2011

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Although Xenopus FKBP1A (xFKBP1A) induces an ectopic dorsal axis in Xenopus embryos, involvement of xFKBP1B, a vertebrate paralogue of FKBP1A, in embryogenesis remains undetermined. Here, we demonstrate that xFKBP1B induces ectopic dorsal axis and involves in eye formation of Xenopus embryos. Injection of the xFKBP1B mRNA in ventral blastomeres of 4-cell stage Xenopus embryos induced a secondary axis and showed multiplier effect to that of xFKBP1A on this when xFKBP1A was co-injected. In addition, BMP4 and Smad1 mRNAs did not affect the ability of xFKBP1B to induce the ectopic secondary axis when either was co-injected with xFKBP1B in ventral blastomeres, whereas they downed out that of xFKBP1A, suggesting that xFKBP1A and xFKBP1B induce the ectopic secondary axis through affecting different pathways from each other. On the other hand, the injection of the FKBP1B mRNA in dorsal blastomeres showed eye malformation, and suppressed almost completely the expression of Rx1, Mitf, and Vax2 mRNAs. xFKBP1B was expressed in the dorsal side of the embryo including the eye during embryogenesis at least until stage 46. Injection of morpholino of the xFKBP1B mRNA in dorsal blastomeres induced additional retina or failed to close tapetum nigrum in the ventral side within the optic cap, whereas it did not affect the dorsal organ development. The injection of the morpholino reduced the expression of Xotx2 and Rx1 mRNAs in the eye. These observations suggest that xFKBP1B is a key factor that regulates the expression levels of the genes involved in eye formation during Xenopus embryogenesis.

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“…2008). FKBP1A and cFKBP/SMAP are also critical for heart development (Obata et al. 2001), and for smooth muscle differentiation in the chick embryo (Fukuda et al.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peptidyl‐prolyl cis‐trans isomerase xFKBP1B induces ectopic secondary axis and is involved in eye formation during Xenopus embryogenesis

2011

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Early events in valvulogenesis: A signaling perspective

Barnett

Desgrosellier

2003

Birth Defects Research Pt C

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The proper formation and function of the vertebrate heart requires a multitude of specific cell and tissue interactions. These interactions drive the early specification and assembly of components of the cardiovascular system that lead to a functioning system before the attainment of the definitive cardiac and vascular structures seen in the adult. Many of these adult structures are hypothesized to require both proper molecular and physical cues to form correctly. Unlike any other organ system in the embryo, the cardiovascular system requires concurrent function and formation for the embryo to survive. An example of this complex interaction between molecular and physical cues is the formation of the valves of the heart. Both molecular cues that regulate cell transformation, migration, and extracellular matrix deposition, and physical cues emanating from the beating heart, as well as hemodynamic forces, are required for valvulogenesis. This review will focus on molecules and emerging pathways that guide early events in valvulogenesis. Birth Defects Research (Part C) 69:58–72, 2003. © 2003 Wiley‐Liss, Inc.

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Heart‐selective expression of the chicken FK506‐binding protein (FKBP) 12.6 gene during embryonic development

Yazawa

Okihara

Iio

et al. 2002

Developmental Dynamics

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FKBP12.6, a member of the family of FK506-binding proteins, selectively associates with the cardiac isoform of the ryanodine receptor and thereby stabilizes this Ca 2؉ release channel. A chicken FKBP12.6 (chFKBP12.6) cDNA was cloned and shown to encode a protein of 108 amino acids. The deduced amino acid sequence of chFKBP12.6 is 91-92% identical to those of mammalian FKBP12.6 proteins. Northern blot analysis revealed that chFKBP12.6 mRNA is largely restricted to the heart during embryonic development and that the abundance of this mRNA in the heart decreases, and it becomes restricted to the atrium during cardiogenesis. In situ hybridization revealed that chFKBP12.6 mRNA is localized to the precardiac mesoderm before formation of the primitive heart tube. Expression of the chFKBP12.6 gene was initially apparent throughout the developing multichambered heart but became restricted to the atria before hatching. Reverse transcription and polymerase chain reaction analysis demonstrated that chFKBP12.6 mRNA is present in the embryo from early gastrulation and is most abundant immediately after the onset of the heartbeat. These observations suggest that the chFKBP12.6 gene is expressed before heart morphogenesis to play a role in excitation-contraction coupling in cardiomyocytes and that the function of the encoded protein becomes increasingly restricted to the atrium during embryonic development. Developmental Dynamics 226:33-41, 2003.

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Role of FK506-Binding Protein 12 in Development of the Chick Embryonic Heart

Cited by 6 publications

References 31 publications

Peptidyl‐prolyl cis‐trans isomerase xFKBP1B induces ectopic secondary axis and is involved in eye formation during Xenopus embryogenesis

Peptidyl‐prolyl cis‐trans isomerase xFKBP1B induces ectopic secondary axis and is involved in eye formation during Xenopus embryogenesis

Early events in valvulogenesis: A signaling perspective

Heart‐selective expression of the chicken FK506‐binding protein (FKBP) 12.6 gene during embryonic development

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