Role of Fisetin in Selected Malignant Neoplasms in Women

Abstract

A promising therapeutic window and cost-effectiveness are just two of the potential advantages of using naturally derived drugs. Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a natural flavonoid of the flavonol group, commonly found in fruit and vegetables. In recent years, fisetin has gained wide attention across the scientific community because of its broad spectrum of pharmacological properties, including cytotoxic activity against most abundant cancers. By stimulating or inhibiting selected molecular targets or biochemical processes, fisetin could affect the reduction of metastasis or cancer progression, which indicates its chemotherapeutic or chemopreventive role. In this review, we have summarized the results of studies on the anticancer effects of fisetin on selected female malignancies, both in in vitro and in vivo tests, i.e., breast, cervical, and ovarian cancer, published over the past two decades. Until now, no article dedicated exclusively to the action of fisetin on female malignancies has appeared. This review also describes a growing number of nanodelivery systems designed to improve the bioavailability and solubility of this natural compound. The reported low toxicity and activity of fisetin on cancer cells indicate its valuable potential, but large-scale clinical trials are urgently needed to assess real chemotherapeutic efficacy of this flavonoid.

Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity

“…The inhibitory effect of FIS on cholinesterases AChE and BChE has been documented in the literature [24,108]. The SAR analysis suggests that the primary factor contributing Studies on the structure-activity relationship (SAR) of FIS have been the subject of numerous literature reports [1,[98][99][100][101]. It is indicated that the three-OH group has the greatest contribution to the antioxidant properties of FIS, while the double bond between the two-and three-carbon groups, and three ′ -OH and four ′ -OH groups (B-ring) are capable of enhancing its antioxidative activity [102].…”

Antiplatelet Effects of Flavonoid Aglycones Are Mediated by Activation of Cyclic Nucleotide-Dependent Protein Kinases

“…Additionally, flavonoids demonstrate anticancer effects by inhibiting growth and inducing apoptosis in cancer cell lines [26][27][28][29], and have the ability to enhance cell survival in non-tumor cells [30][31][32][33]. Considered safe with a wide therapeutic window [34], flavonoids emerge as promising candidates for medical application, causing particular interest in investigating their biological effects. Recent clinical trials have shown the ability of flavonoids to improve post-COVID-19 olfactory dysfunction, reduce hypercoagulability and symptoms of rheumatoid arthritis [35][36][37].…”

Nutritional Strategy for Cancer—From Prevention to Aftercare

“…Markowska et al conducted a review focusing on the anticancer properties of fisetin, a representative flavonol. Their analysis suggests that fisetin exhibits anti-cancer efficacy in female malignancies [12]. Its capacity to upregulate pro-apoptotic genes, such as caspase 3/8 and Bax, while downregulating the expression of the anti-apoptotic protein Bcl-2, is thought to be responsible for the anti-cancer effect in general.…”

“…Additionally, investigating combination strategies, particularly those involving metabolic inhibitors, holds the potential to optimize treatment modalities or circumvent the mechanisms of drug resistance. Notably, two clinical trials are presently in the planning stages to address these aspects [12].…”