Role of first‐trimester three‐dimensional (3D) power Doppler of placental blood flow and 3D placental volume in early prediction of pre‐eclampsia

Abdallah, Ameer; Khairy, Mohammed; Tawfik, Mohamed A.; Mohamed, Safaa; Abdel-Rasheed, Mazen; Salem, S. A.; Khalifa, Eissa

doi:10.1002/ijgo.13572

Cited by 12 publications

(6 citation statements)

References 46 publications

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“…Previous studies report significantly lower VI, FI, and VFI in the first and second trimester in the PE group 10,11 . However, we found no significant differences in VI, FI, and VFI in the third trimester, possibly because, in the first and second trimesters, IBV had not yet developed to accurately represent the ischemic state of IS.…”

Section: Discussioncontrasting

confidence: 87%

“…21 Previous studies report significantly lower VI, FI, and VFI in the first and second trimester in the PE group. 10,11 However, we found no significant differences in VI, FI, and VFI in the third trimester, possibly because, in the first and second trimesters, IBV had not yet developed to accurately represent the ischemic state of IS. In the third trimester, IBV and erythrocyte count increased as a compensatory response of the fetus to IS ischemia, and it is likely that the VI, FI, and VFI values did not decrease despite placental circulatory failure.…”

Section: Discussionmentioning

confidence: 55%

“…[6][7][8][9][10] The vascularization index (VI), flow index (FI), and vascularization flow index (VFI) are measured in the first trimester, with low values indicating increased risk of developing PE in the second and third trimesters. 11,12 However, it is not known whether VI, FI, and VFI correlate with placental morphology.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between placental hemodynamics and placental histological analysis in third trimester

Sakuragi

Shibata

Kondo

et al. 2022

J of Obstet and Gynaecol

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Aim: To investigate whether vascularization index (VI), flow index (FI), and vascularization flow index (VFI) correlate with the pathological structure of the placenta and whether there were any differences in VI, FI, VFI, and placental pathological structure between the normal and preeclampsia (PE) groups. Methods: Fifty-five pregnant women (normal group, n = 27; PE group, n = 28) underwent VI, FI, and VFI at four locations in the placenta during the second and third trimesters. Two hematoxylin and eosin (HE)stained specimens of the postpartum placenta were prepared. We randomly selected two of these locations and used ImageJ, an open-source image package, to quantify intervillous blood vessels (IBV), intervillous spaces (IS), and intervillous blood vessels + intervillous spaces (IBV + IS) per unit placenta and analyzed their correlation with VI, FI, and VFI. Results: There was no positive correlation between VI, FI, VFI, IBV, IS, and IBV + IS. There were no significant differences in VI, FI, and VFI between the normal and PE groups; however, there were significant differences in IBV, IS, and IBV + IS in the PE group compared to those in the normal group. Conclusions: Placental hemodynamics measured by VI, FI, and VFI were not positively correlated with placental morphology in the third trimester. There were no differences in the VI, FI, and VFI in the third trimester between the normal and PE groups, suggesting that these may reflect placental circulatory insufficiency.

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionmentioning

confidence: 55%

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Relationship between placental hemodynamics and placental histological analysis in third trimester

Sakuragi

Shibata

Kondo

et al. 2022

J of Obstet and Gynaecol

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“…However, the ultrasound imaging of the placenta is rather unsatisfactory in the first trimester. 3D-PDU showed a high sensitivity in visualization of villous blood vessels in placenta and even distal branches, providing information about vascular density, diameter change, and curvature and calculating three vascular indexes such as VI, FI, and VFI in the form of a histogram to achieve the quantitative evaluation of blood vessel density and blood perfusion in the placenta [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

The Application Value of Three-Dimensional Power Doppler Ultrasound in Fetal Growth Restriction

Wang¹,

Li²,

Lei³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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In this study, the application value of three-dimensional power Doppler ultrasound (3D-PDU) in fetal growth restriction (FGR) is explored. The retrospective cohort study enrolled pregnant women (with a gestational week of 11–13 + 6 weeks) who received routine health care in the obstetrics and gynecology clinic of our hospital from January 2020 to January 2021. The placentae were scanned using 3D-PDU, and the subjects were followed up until delivery. The fetuses were divided into the control group (n = 322) and FGR group (n = 44) according to their birth weight. There was no significant difference in nuchal translucency (NT), crown-rump length (CRL), and placental volume (PV) during the first trimester between the two groups ( P > 0.05 ). Compared with the control group, the FGR group showed significantly lower levels of vascularisation index (VI), flow index (FI), and vascularisation flow index (VFI) and a higher incidence of fetal distress and neonatal asphyxia ( P < 0.05 ). The FGR group showed a longer gestational week at birth, a higher probability of cesarean section, and a lower 5-minute Apgar score than the control group ( P < 0.05 ). The VI, FI, and VFI of the control group were significantly higher than those of the FGR group. Pearson analysis showed that birth weight was positively correlated with VI and FI ( P < 0.05 ). 3D-PDU assesses the blood perfusion of the fetus and placenta in the first trimester and predicts the pregnancy outcome, which shows great potential in the early diagnosis of FGR.

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“…Thus the applicability of placental volume assessment alone as an early predictor of preeclampsia severity of is limited benefit. In another study, Abdallah et al (14) revealed that women who develop preeclampsia had a significantly lower placental volume than normotensive women. During the first trimester of the study mentioned above, the placental volume was estimated.…”

Section: Discussionmentioning

confidence: 95%

The Use of Three-Dimensional Power Doppler Ultrasound in Assessment of Placental Blood Flow and Volume and Its Correlation with Severity of Preeclampsia

Haggag¹,

Mahmoud²,

Elsayed³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Hypertensive disorders in pregnancy, especially preeclampsia are among the commonest medical disorders encountered in pregnancy and major contributors to maternal & fetal morbidity and mortality. Objective: Assessment of the efficacy of 3 rd trimester three-dimensional power Doppler (3D PD) ultrasound of placental volume and vascular indices in determining the severity of preeclampsia. Subjects and Methods: A cross-sectional analytic study involving 200 women from 18 to 35 years old, with singleton pregnancies in the third trimester complicated with preeclampsia. The subjects were further divided into two groups of 100 patients stratified by disease severity; severe group and non-severe group. Results: The non-severe and severe preeclamptic groups had a significant decrease in placental volume. No significant correlation was found between gestational age and placental volume regarding severity of preeclampsia. The non-severe group had significantly higher values for each of the 3 indices: Vascularization index (VI), Flow index (FI), and Vascularization Flow index (VFI) (16.9 versus 8.5), (36 versus 26), and (4.9 versus 2.6), respectively, compared to the severe group. Both the non-severe and the severe groups had a significant negative correlation between gestational age (GA) and VFI. Additionally, neither the severe nor the non-severe groups showed any correlation between VI and GA, while FI showed a non-significant inverse correlation with GA. Conclusion: The 3D Power Doppler ultrasound may provide alternative methods for assessment of placental blood flow and provide insights on pathophysiology of placental disease. Additional studies are required for verification of its accuracy and applicability in clinical practice.

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Role of first‐trimester three‐dimensional (3D) power Doppler of placental blood flow and 3D placental volume in early prediction of pre‐eclampsia

Cited by 12 publications

References 46 publications

Relationship between placental hemodynamics and placental histological analysis in third trimester

Relationship between placental hemodynamics and placental histological analysis in third trimester

The Application Value of Three-Dimensional Power Doppler Ultrasound in Fetal Growth Restriction

The Use of Three-Dimensional Power Doppler Ultrasound in Assessment of Placental Blood Flow and Volume and Its Correlation with Severity of Preeclampsia

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