Role of ferroptosis in pregnancy related diseases and its therapeutic potential

Xu, Jinfeng; Zhang, Fan; Wang, Xiaodong; Mo, Chunheng

doi:10.3389/fcell.2023.1083838

Cited by 9 publications

(4 citation statements)

References 168 publications

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“…For example, several new cell death related pathways (including necroptosis, pyroptosis, ferroptosis, and cuproptosis) have been found to play important roles in various physiological and pathological processes ( 96 ). Among these pathways, ferroptosis is especially found to be associated with pregnancy related diseases and could be a potential target for therapy ( 97 ). As mentioned above, initial proteomics screening of placenta tissue showed that differentially expressed proteins are highly associated with apoptosis and autophagy based on functional annotation.…”

Section: Suggestions Of New Research Directions For Future Omics Studiesmentioning

confidence: 99%

An omics review and perspective of researches on intrahepatic cholestasis of pregnancy

Wang,

Chen,

et al. 2024

Front. Endocrinol.

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Intrahepatic cholestasis of pregnancy (ICP) is one of the common pregnancy complications that may threaten the health of both pregnant women and their fetuses. Hence, it is of vital importance to identify key moleculars and the associated functional pathways of ICP, which will help us to better understand the pathological mechanisms as well as to develop precise clinical biomarkers. The emerging and developing of multiple omics approaches enable comprehensive studies of the genome, transcriptome, proteome and metabolome of clinical samples. The present review collected and summarized the omics based studies of ICP, aiming to provide an overview of the current progress, limitations and future directions. Briefly, these studies covered a broad range of research contents by the comparing of different experimental groups including ICP patients, ICP subtypes, ICP fetuses, ICP models and other complications. Correspondingly, the studied samples contain various types of clinical samples, in vitro cultured tissues, cell lines and the samples from animal models. According to the main research objectives, we further categorized these studies into two groups: pathogenesis and diagnosis analyses. The pathogenesis studies identified tens of functional pathways that may represent the key regulatory events for the occurrence, progression, treatment and fetal effects of ICP. On the other hand, the diagnosis studies tested more than 40 potential models for the early-prediction, diagnosis, grading, prognosis or differential diagnosis of ICP. Apart from these achievements, we also evaluated the limitations of current studies, and emphasized that many aspects of clinical characteristics, sample processing, and analytical method can greatly affect the reliability and repeatability of omics results. Finally, we also pointed out several new directions for the omics based analyses of ICP and other perinatal associated conditions in the future.

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Section: Suggestions Of New Research Directions For Future Omics Studiesmentioning

confidence: 99%

An omics review and perspective of researches on intrahepatic cholestasis of pregnancy

Wang,

Chen,

et al. 2024

Front. Endocrinol.

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“…Hypofibrinolytic conditions that increase the risk of fetal growth restriction, apart from emotional responses, include inflammatory conditions as diverse as obesity, 75 autoimmune diseases, 76 silicone breast implants, 77 gut dysbiosis, 78 giardiasis, 79 and ferroptosis, 80 81 a condition associated with iron toxicity characterized by increased levels of TGF-β, as well as hyperhomocysteinemia, 82 hypothyroidism, 83 Cushing's syndrome, 84 and autoantibodies such as antiphospholipid antibodies. 76 85 The PAI-1 4G allele does not seem to contribute to fetal growth restriction, 86 87 supporting the idea that decreased villous branching depends mostly on factors occurring in late pregnancy.…”

Section: Normotensive Fetal Growth Restrictionmentioning

confidence: 99%

The Impact of Emotional Responses on Female Reproduction: Fibrinolysis in the Spotlight

Hoirisch-Clapauch

2024

Semin Thromb Hemost

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Fibrinolytic enzymes modify various substrates required for tissue remodeling, playing a crucial role in mechanisms underlying resilience, reward processing, ovulation, embryo implantation, and placentation. Individuals with low resilience and reduced reward responsiveness, when exposed to chronic stress, are at increased risk of experiencing a range of negative emotions. Chronic anxiety and melancholia are examples of negative emotions associated with hypercortisolism, while fear and atypical depression are characterized by systemic inflammation. Both cortisol and inflammatory cytokines stimulate the production of plasminogen activator inhibitor-1 (PAI-1), a potent fibrinolysis inhibitor. Chronic anxiety, fear, and depression are among the many hypofibrinolytic conditions increasing the risk of oligo-anovulation, miscarriage, fetal growth restriction, and preeclampsia. Although significant, the impact of negative emotions on implantation is not as obvious as on ovulation or placentation. Other hypofibrinolytic conditions that may affect female reproduction through mechanisms dependent or independent of PAI-1 include metabolic disturbances (e.g., due to consumption of highly palatable foods, often used to alleviate negative affect), inflammation, hyperhomocysteinemia, hypothyroidism, hypercortisolism, antiphospholipid antibodies, and the 4G allele of the PAI-1 gene. Benzodiazepines and antidepressants should be used with caution in the first trimester as this combination may cause malformations. Also, selective serotonin reuptake inhibitors have fibrinolytic properties that increase the risk of bleeding after surgical procedures. Psychological interventions, especially group therapy, are effective in the prevention of reproductive disorders. Controlled trials are needed to test the hypothesis that female reproductive health depends on psychological well-being, a balanced diet and physical activity, suppression of inflammation and autoantibodies, and homocysteine and hormonal homeostasis.

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“…Recently, ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, has been associated with the pathogenesis of COPD. [ 1 ] Multiple signaling pathways, such as glutathione peroxidase 4 (GPX4), ferroptosis suppressor protein 1 (FSP1), and tetrahydrobiopterin-dependent pathways, as well as iron metabolism, are involved in regulating ferroptosis [ 2 , 3 ] [Figure 1 A]. Here, we provide a comprehensive overview of recent advances in understanding the role of ferroptosis in COPD, highlighting potential therapeutic strategies targeting ferroptosis for treating the disease.…”

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confidence: 99%

Ferroptosis in chronic obstructive pulmonary disease: From cellular mechanisms to therapeutic applications

Yan,

Xu,

Wang

et al. 2024

Chinese Medical Journal

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Role of ferroptosis in pregnancy related diseases and its therapeutic potential

Cited by 9 publications

References 168 publications

An omics review and perspective of researches on intrahepatic cholestasis of pregnancy

An omics review and perspective of researches on intrahepatic cholestasis of pregnancy

The Impact of Emotional Responses on Female Reproduction: Fibrinolysis in the Spotlight

Ferroptosis in chronic obstructive pulmonary disease: From cellular mechanisms to therapeutic applications

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