Role of ferroptosis in effects of anesthetics on multiple organ diseases: A literature review

Abudurousuli, Gulibositan; Xu, Siyang; Che, Jinxing; Ding, Xiahao; Gui, Bo; Zhu, Linjia

doi:10.1016/j.heliyon.2023.e20405

Cited by 2 publications

(1 citation statement)

References 75 publications

(85 reference statements)

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“…Lastly, some evidence suggests that anesthetics can also possess anti-cancer properties by inducing ferroptosis ( Abudurousuli et al, 2023 ). This becomes more intriguing when inhibiting PI3K/Akt by local anesthetic agents, such as bupivacaine and ropivacaine, can trigger these ferroptotic changes ( Hao et al, 2022 ; Lu et al, 2022 ).…”

Section: Targeting Pi3k/akt To Induce Ferroptosismentioning

confidence: 99%

Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer

Su,

Peng,

Liu

2024

Front. Cell Dev. Biol.

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The global challenge posed by cancer, marked by rising incidence and mortality rates, underscores the urgency for innovative therapeutic approaches. The PI3K/Akt signaling pathway, frequently amplified in various cancers, is central in regulating essential cellular processes. Its dysregulation, often stemming from genetic mutations, significantly contributes to cancer initiation, progression, and resistance to therapy. Concurrently, ferroptosis, a recently discovered form of regulated cell death characterized by iron-dependent processes and lipid reactive oxygen species buildup, holds implications for diseases, including cancer. Exploring the interplay between the dysregulated PI3K/Akt pathway and ferroptosis unveils potential insights into the molecular mechanisms driving or inhibiting ferroptotic processes in cancer cells. Evidence suggests that inhibiting the PI3K/Akt pathway may sensitize cancer cells to ferroptosis induction, offering a promising strategy to overcome drug resistance. This review aims to provide a comprehensive exploration of this interplay, shedding light on the potential for disrupting the PI3K/Akt pathway to enhance ferroptosis as an alternative route for inducing cell death and improving cancer treatment outcomes.

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Section: Targeting Pi3k/akt To Induce Ferroptosismentioning

confidence: 99%