Role of Fecal Calprotectin for Assessment of Inflammatory Bowel Disease Activity, 4-Year Study Done in Indian Reference Laboratory

Abstract

Introduction:-Calprotectin is calcium binding protein which is secreted by neutrophils & monocytes. It is found both in plasma & in stools. It is predominantly elevated in inammatory conditions such as inammatory bowel disease (IBD). To a certain extent, it is also elevated in infectious conditions & in polyposis. This study was conducted to evaluate diagnostic precision of fecal calprotectin in known inammatory bowel disease (IBD) patients A retrospect Method:- ive analysis of calprotectin, ASCA, cANCA, pANCA, Total WBC count, ESR, CRP was obtained in referral laboratory in Mumbai over a span of 4 years (2018-2022). Prevalence of raised Results:- calprotectin was signicantly seen in 13-18 years age group. (P<0.0001). Calprotectin showed a positive correlation with WBC count, CRP & ESR. There was no signicant association between calprotectin levels & gender. Fecal calprotectin can be used not only in research Conclusion:- but also in routine clinical practice in differentiating between patients with inammatory & non-inammatory bowel disease. Aims and Objectives: - 1. To study the prevalence of fecal calprotectin levels with respect to different age groups & gender in inammatory bowel disease patients. 2. To establish correlation of fecal calprotectin levels with ANCA, ASCA, Total WBC count, ESR &CRP