Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder

Praschak-Rieder, Nicole; Willeit, Matthäus; Winkler, Dietmar; Neumeister, Alexander; Hilger, Eva; Zill, Peter; Hornik, Kurt; Stastny, J.; Thierry, Nikolaus; Ackenheil, Manfred; Bondy, Brigitta; Kasper, Siegfried

doi:10.1016/s0924-977x(01)00146-8

Cited by 37 publications

(19 citation statements)

References 45 publications

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“…Regarding the bipolar subtype, PMDD was more common in BD II . PMDD and SAD are believed to share a common genetic background, and the serotonin system may be a candidate (Praschak-Rieder et al, 2002). Our findings, combined with previous evidence, suggest that PMDD observed in bipolar patients may be another marker for cyclic disorder and an epigenetic expression of the underlying "BD IIseasonality-female" pathophysiology.…”

Section: Discussionsupporting

confidence: 70%

Seasonality and its distinct clinical correlates in bipolar II disorder

Kim¹,

Ha²,

Chang³

et al. 2015

Psychiatry Research

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Section: Discussionsupporting

confidence: 70%

Seasonality and its distinct clinical correlates in bipolar II disorder

Kim¹,

Ha²,

Chang³

et al. 2015

Psychiatry Research

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“…Overlap of PMDD with genetic liability for MDD, seasonal affective disorder and personality characteristics has been suggested. 24,25 The diagnosis of PMDD requires the confirmation of luteal-phase impairment of social and/or work functioning that is due to premenstrual symptoms. The functional impairment reported by women with PMDD is similar in severity to the impairment reported in MDD and dysthymic disorder.…”

Section: Epidemiologymentioning

confidence: 99%

Premenstrual Dysphoric Disorder: Burden of Illness and Treatment Update

Pearlstein¹,

Steiner²

2012

FOC

103

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291Five percent of menstruating women have severe premenstrual symptoms and impairment of functioning defined as premenstrual dysphoric disorder (PMDD). Clinically significant premenstrual symptoms occur in at least an additional 20% of menstruating women. The diagnosis of PMDD should be confirmed by prospective symptom charting over 2 menstrual cycles to confirm the timing of the symptoms and to rule out other diagnoses. The burden of illness of PMDD includes disruption of parenting and partner relationships and decreased productivity in work roles. In addition, women with PMDD have increased use of health care services such as clinician visits and increased use of prescription medications and over-the-counter preparations. The etiology of PMDD is multifactorial. In particular, dysregulation of the serotonin and allopregnanolone systems is implicated. Several effective treatment options exist, including serotonergic antidepressant medications and an oral contraceptive that contains ethinyl estradiol and drosperinone. In addition, other hormones that suppress ovulation, anxiolytics, cognitive therapy, chasteberry and calcium may be helpful.Cinq pour cent des femmes menstruées ont des symptômes prémenstruels sévères et une incapacité du fonctionnement appelée trouble dysphorique prémenstruel (TDPM). Au moins 20 % de femmes menstruées de plus ont des symptômes prémenstruels cliniquement significatifs. Il faut confirmer le diagnostic de TDPM en suivant les symptômes de façon prospective au cours de deux cycles menstruels afin de confirmer le moment de l'apparition des symptômes et d'exclure d'autres diagnostics. Le fardeau morbide imposé par le TDPM comprend la perturbation des relations avec les enfants et le partenaire et une baisse de productivité au travail. Les femmes atteintes de TDPM ont en outre recours davantage aux services de santé comme les visites aux cliniciens et prennent davantage de médicaments d'ordonnance et en vente libre. L'étiologie du TDPM est multifactorielle. La dysrégulation des systèmes de la sérotonine et de l'allopregnanolone en particulier est mise en cause. Il existe plus d'un traitement efficace possible, y compris des antidépresseurs sérotonin-ergiques et un contraceptif oral qui contient de l'éthinyloestradiol et de la drosperinone. D'autres hormones qui bloquent l'ovulation, des anxiolytiques, la thérapie cognitive, le gattilier (Vitex agnus castus) et le calcium peuvent en outre aider. Review Paper Examen critique DiagnosisAbout 80% of women report at least mild premenstrual symptoms, 20%-50% report moderate-to-severe premenstrual symptoms, and about 5% report severe symptoms for several days with impairment of functioning.

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“…Studies that do not show correlations between neuroticism and 5-HTTLPR are, however, typically based on healthy participants. In populations with major depression or seasonal affective depression, associations between 5-HTTLPR and neuroticism are more commonly reported (Munafo et al 2006; Praschak-Rieder et al 2002). …”

Section: Introductionmentioning

confidence: 99%

Neuroticism-related personality traits are related to symptom severity in patients with premenstrual dysphoric disorder and to the serotonin transporter gene-linked polymorphism 5-HTTPLPR

Gingnell

Comasco

Oreland

et al. 2010

Arch Womens Ment Health

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Neuroticism has been linked to a functional polymorphism in the serotonin transporter gene (5-HTTLPR), with short-allele carriers being overrepresented among high-scorers on neuroticism. Studies evaluating neuroticism-related personality traits in relation to the 5-HTTLPR polymorphism among patients with premenstrual dysphoric disorder (PMDD) and are lacking. The primary aim of this study was to evaluate the relationship between PMDD and neuroticism-related personality traits, and secondly, to relate the personality trait scores of PMDD patients to experienced symptom severity and to the 5-HTTLPR short allele. Thirty PMDD patients and 55 asymptomatic healthy controls were included in the study. The Swedish Universities Scale of Personality was used to evaluate personality traits. Genotype analyses were available in 27 PMDD patients and 18 healthy controls. Women with PMDD displayed higher levels of neuroticism-related personality traits (psychic trait anxiety, somatic trait anxiety, embitterment, stress susceptibility and mistrust) than healthy controls, and these effects were most prominent in women with more severe luteal phase symptoms. Furthermore, PMDD patients with at least one copy of the short allele of the 5-HTTLPR polymorphism scored higher on psychic trait anxiety and lack of assertiveness than PMDD patients who were homozygous for the long allele. PMDD patients who suffer from more severe luteal phase symptoms also display increased scores of neuroticism-related personality traits in comparison with healthy controls. Within the group of PMDD patients, differences in certain personality trait scores are associated with the short allele of the 5-HTTLPR polymorphism.

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Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder

Cited by 37 publications

References 45 publications

Seasonality and its distinct clinical correlates in bipolar II disorder

Seasonality and its distinct clinical correlates in bipolar II disorder

Premenstrual Dysphoric Disorder: Burden of Illness and Treatment Update

Neuroticism-related personality traits are related to symptom severity in patients with premenstrual dysphoric disorder and to the serotonin transporter gene-linked polymorphism 5-HTTPLPR

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