Role of EZH2-mediated epigenetic modification on vascular smooth muscle in cardiovascular diseases: A mini-review
Haiyan Luo,
Yao Li,
Honghu Song
et al.
Abstract:Vascular smooth muscle cells (VSMCs) are integral to the pathophysiology of cardiovascular diseases (CVDs). Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, plays a crucial role in epigenetic regulation of VSMCs gene expression. Emerging researches suggest that EZH2 has a dual role in VSMCs, contingent on the pathological context of specific CVDs. This mini-review synthesizes the current knowledge on the mechanisms by which EZH2 regulates VSMC proliferation, migration and survival in the contex… Show more
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