Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation

Abstract

ObjectiveTo assess role of some inflammatory mediators in patients with primary and recurrent lumbar disc herniation. Expression of IL-6, transforming growth factor (TGF)-1, insulin-like growth factor (IGF)-1, and Bcl-2-associated X protein (BAX) have been shown to be more intense in the primary group than the recurrent goup, but this mediators may be important aspects prognostic.Methods19 patients underwent primary and revision operations between June 1, 2009 and June 1, 2014, and they were included in this study. The 19 patients’ intervertebral disc specimens obtained from the primary procedures and reoperations were evaluated. Expression of IL-6, TGF-1, IGF-1, and BAX were examined immunohistochemically in the 38 biopsy tissues obtained from the primary and recurrent herniated intervertebral discs during the operation.ResultsFor IL-6 expression in the intervertebral disc specimens, there was no difference between the groups. The immunohistochemical study showed that the intervertebral disc specimens in the primary group were stained intensely by TGF-1 compared with the recurrent group. Expression of IGF-1 in the primary group was found moderate. In contrast, in the recurrent group of patients was mild expression of IGF-1. The primary group intervertebral disc specimens were stained moderately by BAX compared with the recurrent group.ConclusionThe results of our prognostic evaluation of patients in the recurrent group who were operated due to disc herniation suggest that mediators may be important parameters.

Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation

“…Insulin-like growth factor 1 (IGF-1) has an important role in promoting cell proliferation and apoptosis inhibition. However, previous studies in this area have mostly focused on malignant tumors [3,6,8,10,16], and there have been few studies on lumbar disc herniation. Relevant investigations proved that activation of the IGF-1 factor can activate the PI3K/AKT signal pathway [5,7–9].…”

“…Most of the symptoms can be relieved or cured by non-operative therapy. Currently, imaging studies have confirmed that disc herniation can be gradually reduced or eliminated [7,8], and this morphological change of the protruding tissue is one of the reasons for effective non-operative treatment [9]. Whether the disc herniation is natural absorption or reduction can be determined by easy absorption of the rupture-type intervertebral disc, such as the free type and the pierced longitudinal ligament type [10–13].…”