Role of experimental conditions in determining differences in exploratory behavior of prenatally stressed rats

Poltyrev, Tatyana; Keshet, Gilmor I.; Kay, Gillian; Weinstock, Marta

doi:10.1002/(sici)1098-2302(199607)29:5<453::aid-dev4>3.0.co;2-n

Cited by 117 publications

(44 citation statements)

References 32 publications

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“…Adult male offspring of rats exposed to social stress during pregnancy display increased anxiety-related behaviour on the elevated plus maze (Brunton & Russell 2010) and in the open field (Abe et al 2007) and increased depression-like behaviour in a forced swim test (Abe et al 2007), consistent with the findings of studies using other prenatal stress paradigms (Poltyrev et al 1996, Vallee et al 1997. By contrast, prenatal social stress in late pregnancy does not appear to affect anxiety-type behaviour in female offspring (Brunton & Russell 2010), except when given in combination with another psychological stressor (restraint) in early-mid pregnancy (Bosch et al 2007).…”

Section: Effects On Anxiety-like Behaviour In Prenatally Stressed Offmentioning

confidence: 99%

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

2013

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A suboptimal in utero environment, for example, as a result of maternal stress, can have detrimental effects on the pregnancy and long-term adverse 'programming' effects on the offspring. This article focuses on the effects of prenatal social stress on the mother, her pregnancy and the offspring, since these issues have ethological relevance in both animals and humans. The consequences of social stress exposure depend on when during pregnancy the stress occurs, and many of the effects on the offspring are sex specific. Social stress during early pregnancy tends to result in pregnancy loss, whereas stress exposure later in pregnancy, when the mother has already invested considerable resources in the foetuses, results in programmed offspring of low birth weight: a risk factor for various adulthood diseases. Neuroendocrine and behavioural responses to stress in the offspring are particularly sensitive to foetal programming by prenatal stress, indicated by enhanced hypothalamo-pituitary-adrenal (HPA) axis responses and increased anxiety behaviour, which result from permanent changes in the offspring's brain. The dysregulation of HPA axis function may also interfere with other systems, for example, the hypothalamic-pituitary-gonadal axis, as there is evidence for alterations in steroidogenesis, reproductive potential and impaired reproductive/social behaviours in prenatally stressed offspring. Prenatal social stress also programmes future maternal behaviour, highlighting the potential for negative phenotypes to be transmitted to future generations. The possible mechanisms through which maternal stress during pregnancy is transmitted to the foetuses and the foetal brain is programmed by prenatal stress and the potential to overwrite programming of the offspring are discussed.Reproduction (2013) 146 R175-R189

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Section: Effects On Anxiety-like Behaviour In Prenatally Stressed Offmentioning

confidence: 99%

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

2013

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“…We have previously reported that a state of hyperanxiety and impaired coping under stress in the adult offspring can be generated by maternal stress occurring during a critical period during gestation (Fride et al 1985(Fride et al , 1986Wakshlak and Weinstock 1990;Poltyrev et al 1996;Weinstock 1997). These findings have independently been replicated in other studies using different forms of maternal stress (VallØe et al 1997;Zimmerberg and Blaskey 1998;Ward et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Gender difference in the prevention of hyperanxiety in adult prenatally stressed rats by chronic treatment with amitriptyline

Poltyrev

Weinstock

2004

Psychopharmacology

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“…For example, in neonates, PS increases ultrasonic vocalization during isolation stress (Takahashi et al 1990), while in juveniles, PS decreases the propensity to play in a novel environment and increases shock-induced freezing (Takahashi et al 1992a). In adults PS is characterized by increased defensive withdrawal (Ward et al 2000) and less time spent in the open arms of the elevated plus maze (Fride et al 1986;Poltyrev et al 1996).…”

Section: Introductionmentioning

confidence: 99%

The differential effects of prenatal stress in rats on the acoustic startle reflex under baseline conditions and in response to anxiogenic drugs

White

Birkle

2001

Psychopharmacology

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Anxiogenic effects of yohimbine, idazoxan, and RS79978-197, likely mediated via alpha2-adrenoceptor blockade, are similar in control and PS rats. Differences between control and PS rats occurred in the response to higher doses of yohimbine and idazoxan. Non-specific effects of these drugs, such as actions at 5HT1A receptors, may cause their behavioral profile to be altered by PS, and to differ from the highly selective RS79948-197.

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Role of experimental conditions in determining differences in exploratory behavior of prenatally stressed rats

Cited by 117 publications

References 32 publications

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

Gender difference in the prevention of hyperanxiety in adult prenatally stressed rats by chronic treatment with amitriptyline

The differential effects of prenatal stress in rats on the acoustic startle reflex under baseline conditions and in response to anxiogenic drugs

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