Role of Exosomes in Epithelial–Mesenchymal Transition

Bhattacharya, Bikramjit; Nag, Sagnik; Mukherjee, Sayantanee; Kulkarni, Mrunal; Chandane, Priti; Mandal, Debashmita; Mukerjee, Nobendu; Mirgh, Divya; Anand, Krishnan; Adhikari, Manab Deb; Gorai, Sukhamoy; Thorat, Nanasaheb

doi:10.1021/acsabm.3c00941

Cited by 6 publications

(2 citation statements)

References 163 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been discovered that exosomes play important roles in many biological processes, including the presentation of antigen, angiogenesis, and intercellular signal transduction. On the one hand, exosomes can promote epithelial-mesenchymal transition (EMT) of tumor cells ( Bhattacharya et al, 2023 ), induce angiogenesis ( Jiang et al, 2022 ), mediate immune escape, regulate macrophage polarization and lipid metabolism to promote tumor development ( Ye et al, 2023 ). For example, LncRNA BCRT1 can promote M2 polarization of macrophages, promote tumor migration and chemotactic ability, and thus promote tumor progression ( Ye et al, 2023 ).…”

Section: Overview Of Exosome Functions and Applicationsmentioning

confidence: 99%

Application of exosomes in tumor immunity: recent progresses

Qiu,

Liang,

Yang

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Exosomes are small extracellular vesicles secreted by cells, ranging in size from 30 to 150 nm. They contain proteins, nucleic acids, lipids, and other bioactive molecules, which play a crucial role in intercellular communication and material transfer. In tumor immunity, exosomes present various functions while the following two are of great importance: regulating the immune response and serving as delivery carriers. This review starts with the introduction of the formation, compositions, functions, isolation, characterization, and applications of exosomes, and subsequently discusses the current status of exosomes in tumor immunotherapy, and the recent applications of exosome-based tumor immunity regulation and antitumor drug delivery. Finally, current challenge and future prospects are proposed and hope to demonstrate inspiration for targeted readers in the field.

show abstract

Section: Overview Of Exosome Functions and Applicationsmentioning

confidence: 99%

Application of exosomes in tumor immunity: recent progresses

Qiu,

Liang,

Yang

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Tumor cell-derived exosomes (TEXs) promote cancer development. 9,10 Exosomes encapsulate a wide array of biomolecules that reflect the physiological state of their parent cells. This cargo includes proteins, lipids, nucleic acids, and metabolites.…”

Section: Exosome Biogenesis and Cellular Communicationmentioning

confidence: 99%

Targeted therapies for HPV‐associated cervical cancer: Harnessing the potential of exosome‐based chipsets in combating leukemia and HPV‐mediated cervical cancer

Maitra,

Mukerjee,

Alharbi

et al. 2024

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

Exosomes play a crucial role in intercellular communication and have emerged as significant vehicles for transporting disease‐specific biomarkers. This feature provides profound insights into the progression of diseases and the responses of patients to treatments. For example, in leukemia, exosomes convey critical information through the carriage of specific proteins and nucleic acids. In the case of human papillomavirus (HPV)‐mediated cervical cancer, exosomes are particularly useful for noninvasive detection as they transport high‐risk HPV DNA and specific biomolecules, which can be indicators of the disease. Despite their vast potential, there are several challenges associated with the use of exosomes in medical diagnostics. These include their inherent heterogeneity, the need for enhanced sensitivity in detection methods, the establishment of standardization protocols, and the requirement for cost‐effective scalability in their application. Addressing these challenges is crucial for the effective implementation of exosome‐based diagnostics. Future research and development are geared towards overcoming these obstacles. Efforts are concentrated on refining the processes of biomarker discovery, establishing comprehensive regulatory frameworks, developing convenient point‐of‐care devices, exploring methods for multimodal detection, and conducting extensive clinical trials. The ultimate goal of these efforts is to inaugurate a new era of precision diagnostics within healthcare. This would significantly improve patient outcomes and reduce the burden of diseases such as leukemia and HPV‐mediated cervical cancer. The integration of exosomes with cutting‐edge technology holds the promise of significantly reinforcing the foundations of healthcare, leading to enhanced diagnostic accuracy, better disease monitoring, and more personalized therapeutic approaches.

show abstract