Abstract:Method:A narrative review of all the articles known to the authors was conducted.Results: Tobacco and diet are the two major sources of exogenous AGE and the foremost characteristic of the glycotoxins, formed from tobacco curing reaction, is their high reactivity and innate ability to cross the cell membrane and bind with serum proteins and formation of adducts with amino acids of nucleic acids. Binding of AGEs to their receptor for AGE activates mechanisms which favor production of reactive oxidative species … Show more
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