Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain

Abstract

The results of this study support the hypothesis that the mtDNA haplogroups have a role in the complex osteoarthritic process.

Molecular Pathogenesis and Genetics of Osteoarthritis: Implications for Personalized Medicine

“…The mechanisms by which stimulation of Fas by the Fas ligand initiates apoptosis have been extensively investigated, and it has been demonstrated that cell death in primary OA chondrocytes is mediated by the Fas pathway [90]. mtDNA variation has been associated with risk of OA of the knee [91] and of the hip [92]. Given the role of mtDNA damage in mitochondria-driven apoptosis, it is possible to speculate that the involvement of mtDNA haplotypes in OA risk may relate to apoptotic pathways.…”

Secretome analysis of human articular chondrocytes unravels catabolic effects of nicotine on the joint

“…Conversely, smoking has also been related with a higher prevalence of knee pain [6] and knee cartilage loss [7,8]. In this area, a retrospective multivariate analysis performed by our group on hip OA samples revealed a negative association between smoking and OA [9].…”

Génétique des maladies du cartilage (arthrose, chondrodysplasies)

“…Il existe probablement une mort cellulaire accrue des chondrocytes au cours de l'arthrose qui pourrait impliquer l'ADN mitochochondrial (ADNmt) dont certaines séquences seraient associées à l'arthrose de hanche et de genou [32,33]. Plus récem-ment, un effet protecteur du polymorphisme rs7164503 du gène ANP32A suppresseur de tumeur a été observé sur le risque de coxarthrose et dans une moindre mesure de gonarthrose dans une étude regroupant quatre cohortes, soit 2170 individus arthrosiques et 2849 témoins féminins [24].…”