Role of Ethnicity in Predicting Antipsychotic Medication Adherence

Abstract

When other factors were controlled for, ethnicity was a significant predictor of medication adherence following initiation on an antipsychotic medication, and patients of all ethnicities were most adherent when taking olanzapine, less adherent when taking risperidone, and least adherent when taking haloperidol.

Psychotropic Medication Nonadherence Among United States Latinos: A Comprehensive Literature Review

“…Study objectives varied, with some focusing specifically on adherence (1, 6, 41, 44–47, 49, 51–60) while others measured adherence as part of studies addressing different questions. Geographically, eight were based in California (6, 42, 43, 47, 48, 50, 54, 55), two in Texas (41, 51), one in New Mexico (52), one in New York (49), one in Connecticut (56), one in Ohio (40), and four were from Veteran’s Administration National Registries (46, 58–60), and three were national studies (1, 45, 57). …”

“…Twelve reports (N= 12) investigated nonadherence to antipsychotics (1, 6, 41–43, 46, 49–51, 54, 58, 59), five antidepressants (45, 47, 52, 55, 57), two mood stabilizers (48, 60), and two a combination of these medications (40, 56). Ten studies focused on schizophrenia or schizoaffective disorder (1, 6, 41–43, 49–51, 59), five on depression (45, 47, 52, 55, 57), three on bipolar disorder (48, 58, 60), and three a combination of those diagnoses (40, 54, 56).…”

“…Ten studies focused on schizophrenia or schizoaffective disorder (1, 6, 41–43, 49–51, 59), five on depression (45, 47, 52, 55, 57), three on bipolar disorder (48, 58, 60), and three a combination of those diagnoses (40, 54, 56). …”

“…have been shown to be generally more objective measures (3, 62). Therefore, we also separately analyzed the 11 papers (1, 6, 46, 48, 51, 52, 54, 56, 58–60) that used these typically more objective measures.…”

“…We did secondary calculations on study data for 11 studies (3 nonadherence percentage calculations (51, 55, 56), two chi-square tests (50, 57), and six both percentage calculations and chi-square tests (1, 40, 47, 49, 58, 60)). For the two studies (55, 56) in which the unadjusted and adjusted nonadherence rates yielded conflicting results, we included both findings, but used the results of the multivariate analysis when describing comparisons in rates between ethnic groups.…”