Role of Ethnicity and Geographic Location on Glioblastoma IDH1/IDH2 Mutations

McCormack, Ryan; Zhu, Ping; Dono, Antonio; Takayasu, Takeshi; Bhatia, Ankush; Blanco, Angel I.; Tandon, Nitin; Ostrom, Quinn T.; Gonzáles, Alberto; Moreno, Sergio; Ballester, Leomar Y.; Esquenazi, Yoshua

doi:10.1016/j.wneu.2021.01.079

Cited by 5 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, there needs to be more epidemiologic information. Most of the articles we found were from Brazil [12,18,23,24] and from Mexico [13,14,17,20,25,26] .We found some from Colombia [22], Argentina [27,28], and Chile [19,21]. Nonetheless, most Latin American countries still need to report their epidemiologic information on gliomas.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Age and sex disparities in Latin-American adults with gliomas: a systematic review and meta-analysis

van′t Hek,

Ortiz-Herrera,

Salazar-Pigeon

et al. 2023

J Neurooncol

View full text Add to dashboard Cite

Objective: This study aimed to identify if there are ethnic differences in the age and sex distribution of gliomas in the Latino adult population.Methods: A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 recommendations. Databases used were MEDLINE, LILACS, Web of Science, and Scopus. Studies were included if they reported the age and/or sex distribution of gliomas in Latin adults, published in English or Spanish from January 1st, 1985, to December 1st, 2022. The quality of the studies was assessed using the Newcastle -Ottawa Quality Assessment Scale and the NIH Quality Assessment Tool [1] Results: From 1,096 articles, fteen studies with information on 6,815 patients were selected for the systematic review, and thirteen were selected for the meta-analysis. The mean ages of diagnosis of glioma and glioblastoma were 50.9, 95\%\ CI [47.8 -53.9] years and 53.33 years, 95 \% CI [51-55.6],respectively. The male-to-female incidence rate ratio of gliomas was 1.39. Conclusion: Our study found mean ages of glioma and glioblastoma were 6 and 10 years lower than those reported in the CBTRUS. Our study suggests disparities in the age and sex distribution of gliomas in Latin America compared to other regions.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Sex differences have been well-established for many brain tumors, including gliomas [20,21]. The maleto-female incidence rate ratio (IRR) of gliomas reported by the CBTRUS is 1.47.…”

Section: Discussionmentioning

confidence: 99%

Age and sex disparities in Latin-American adults with gliomas: a systematic review and meta-analysis

van′t Hek,

Ortiz-Herrera,

Salazar-Pigeon

et al. 2023

J Neurooncol

View full text Add to dashboard Cite

show abstract

“…The demography of ethnic minorities in England reflects the fact that people from these groups are younger and congregate in major cities, such as London, compared to other areas of England. A cohort study from the US also identified that patients of Hispanic background were diagnosed at a younger age compared to non-Hispanic Whites and had an improved overall survival [18]. A report by The King's Fund suggested that, overall, people from ethnic minorities have poorer access to UK healthcare compared to the White British Groups [19], and this could correlate with fewer individuals from these being registered with the NHS.…”

Section: Interpretations and Implicationsmentioning

confidence: 99%

The Influence of Ethnicity on Survival from Malignant Primary Brain Tumours in England: A Population-Based Cohort Study

Wanis

Møller

Ashkan

et al. 2023

Cancers

View full text Add to dashboard Cite

Background: In recent years, the completeness of ethnicity data in the English cancer registration data has greatly improved. Using these data, this study aims to estimate the influence of ethnicity on survival from primary malignant brain tumours. Methods: Demographic and clinical data on adult patients diagnosed with malignant primary brain tumour from 2012 to 2017 were obtained (n = 24,319). Univariate and multivariate Cox proportional hazards regression analyses were used to estimate hazard ratios (HR) for the survival of the ethnic groups up to one year following diagnosis. Logistic regressions were then used to estimate odds ratios (OR) for different ethnic groups of (1) being diagnosed with pathologically confirmed glioblastoma, (2) being diagnosed through a hospital stay that included an emergency admission, and (3) receiving optimal treatment. Results: After an adjustment for known prognostic factors and factors potentially affecting access to healthcare, patients with an Indian background (HR 0.84, 95% CI 0.72–0.98), Any Other White (HR 0.83, 95% CI 0.76–0.91), Other Ethnic Group (HR 0.70, 95% CI 0.62–0.79), and Unknown/Not Stated Ethnicity (HR 0.81, 95% CI 0.75–0.88) had better one-year survivals than the White British Group. Individuals with Unknown ethnicity are less likely be diagnosed with glioblastoma (OR 0.70, 95% CI 0.58–0.84) and less likely to be diagnosed through a hospital stay that included an emergency admission (OR 0.61, 95% CI 0.53–0.69). Conclusion: The demonstrated ethnic variations associated with better brain tumour survival suggests the need to identify risk or protective factors that may underlie these differences in patient outcomes.

show abstract

“…The mutation occurs in either the IDH1 or IDH2 gene in similar amounts in AML patients and almost uniquely in IDH1 in glioblastoma, 28 although recently a significant number of IDH2 mutations were found in glioblastoma patients in the Hispanic population in the United States and Mexico. 29…”

Section: Isocitrate Dehydrogenase 1/2 Mutations and Atp Synthesismentioning

confidence: 99%

Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow

Noorden

Breznik

Novak

et al. 2021

J Histochem Cytochem.

View full text Add to dashboard Cite

Energy production by means of ATP synthesis in cancer cells has been investigated frequently as a potential therapeutic target in this century. Both (an)aerobic glycolysis and oxidative phosphorylation (OXPHOS) have been studied. Here, we review recent literature on energy production in glioblastoma stem cells (GSCs) and leukemic stem cells (LSCs) versus their normal counterparts, neural stem cells (NSCs) and hematopoietic stem cells (HSCs), respectively. These two cancer stem cell types were compared because their niches in glioblastoma tumors and in bone marrow are similar. In this study, it became apparent that (1) ATP is produced in NSCs and HSCs by anaerobic glycolysis, whereas fatty acid oxidation (FAO) is essential for their stem cell fate and (2) ATP is produced in GSCs and LSCs by OXPHOS despite the hypoxic conditions in their niches with FAO and amino acids providing its substrate. These metabolic processes appeared to be under tight control of cellular regulation mechanisms which are discussed in depth. However, our conclusion is that systemic therapeutic targeting of ATP production via glycolysis or OXPHOS is not an attractive option because of its unwanted side effects in cancer patients.

show abstract

Role of Ethnicity and Geographic Location on Glioblastoma IDH1/IDH2 Mutations

Cited by 5 publications

References 45 publications

Age and sex disparities in Latin-American adults with gliomas: a systematic review and meta-analysis

Age and sex disparities in Latin-American adults with gliomas: a systematic review and meta-analysis

The Influence of Ethnicity on Survival from Malignant Primary Brain Tumours in England: A Population-Based Cohort Study

Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow

Contact Info

Product

Resources

About