Role of ethnicity and environment on lifestyle and cardiometabolic profile in the Native American Mapuche population

Fernández‐Cao, José C.; Doepking, Carlos

doi:10.1097/md.0000000000013354

Cited by 2 publications

(2 citation statements)

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“…In particular, it has been demonstrated that circRNA are involved in cardiovascular disease initiation and progression, including atherosclerosis, cardiomyopathy, myocardial infarction, and cardiac fibrosis ( 17 ). In the present study, to determine whether the NPRA-related cardiometabolic profile (a term to describe a group of metabolic factors in cardiac associated with cardiovascular disease, metabolic syndrome and type II diabetes) ( 45 ) is associated with circRNAs, high-throughput screening of the DE-circRNAs was carried out using circRNA microarray analysis. To the best of our knowledge, the present study the first to use circRNA microarray analysis in NPRA −/− and NPRA +/+ mice.…”

Section: Discussionmentioning

confidence: 99%

Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice

Chen¹,

Pan

Shen³

et al. 2020

Mol Med Rep

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Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are important biological markers and regulators of cardiac function. The natriuretic peptide receptor A (NPRA), also known as NPR1 or guanylyl cyclase A, binds ANP and BNP to initiate transmembrane signal transduction by elevating the intracellular levels of cyclic guanosine monophosphate. However, the effects and mechanisms downstream of NPRA are largely unknown. The aim of the present study was to evaluate the changes in the global pattern of mRNA and circular RNA (circRNA) expression in NPRA −/− and NPRA +/+ myocardium. Differentially expressed mRNA molecules were characterised using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis and were found to be primarily related to metabolic processes. Moreover, circRNA expression was also examined, and a possible competing endogenous RNA network consisting of circRNA, microRNA (miRNA), and mRNA molecules was constructed. The results of this study indicated that NPRA may play a role in cardiac metabolism, which could be mediated by circRNA through endogenous competition mechanisms. These findings may provide insight into future characterisation of various ceRNA network pathways.

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Section: Discussionmentioning

confidence: 99%

Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice

Chen¹,

Pan

Shen³

et al. 2020

Mol Med Rep

View full text Add to dashboard Cite

show abstract

“…In the article, “Role of ethnicity and environment on lifestyle and cardiometabolic profile in the Native American Mapuche population: Protocol for a systematic review and meta-analysis”, [1] which appeared in Volume 97, Issue 48 of Medicine , the Extraction Form was not included with the appendices and can be found at.…”

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confidence: 99%