Role of Estradiol-17beta and Progesterone in Regulating Constriction of Ovine Uterine Arteries

Ford, Stephen P.; Weber, Lavern J.; Stormshak, F.

doi:10.1095/biolreprod17.4.480

Cited by 42 publications

(31 citation statements)

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“…In addition, injection of oestrogen into the uterine lumen (Greiss & Miller, 1971) or into the uterine artery (Resnik, Killam, Battaglia, Makowski & Meschia, 1974) of the ewe causes a rapid unilateral increase in uterine blood flow. Administration of oestrogen to ovariectomized ewes also was found to reduce the constrictor responses of uterine arteries to nerve stimulation (Ford et al, 1977b (Perry, Heap & Amoroso, 1973). In addition, Ward, Frost & Ward Orsini (1978) suggest that oestrogen diffusing from implanting rat embryos partly saturate the hormone binding capacity of the adjacent endometrium.…”

Section: Discussionmentioning

confidence: 91%

Uterine blood flow of cows during the oestrous cycle and early pregnancy: effect of the conceptus on the uterine blood supply

Ford¹,

Chenault²,

Echternkamp³

1979

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120

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Section: Discussionmentioning

confidence: 91%

Uterine blood flow of cows during the oestrous cycle and early pregnancy: effect of the conceptus on the uterine blood supply

Ford¹,

Chenault²,

Echternkamp³

1979

Reproduction

Self Cite

120

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“…Oestradiol increases the rate of protein synthesis and decreases net production of PGF in caruncular tissue (Findlay et al, 1981); it stimulates uterine blood flow when injected into the circulation (Greiss & Anderson, 1970b) or into the uterine lumen (Greiss & Miller, 1971); and reduces the vasoconstrictor response of the uterine artery to sympathetic nerve stimulation (Ford, Weber & Stormshak, 1977). However, the production of oestrogens by the sheep conceptus during the peri-implantation period could not be demonstrated (Gadsby, Heap & Burton, 1980;Heap et al, 1981), though this may be due to an inability to detect a low level of activity rather than a complete absence of oestrogen production.…”

Section: Introductionmentioning

confidence: 99%

Uterine blood flow, myometrial activity and their response to adenosine during the peri-implantation period in sheep

Fleet¹,

Heap²

1982

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Summary. Uterine blood flow and myometrial activity were measured simultaneously in anaesthetized sheep 15 days after a sterile (non-pregnant group) or fertile (pregnant) mating. During the peri-implantation period uterine blood flow was similar in both groups of animals, but spontaneous myometrial activity was greatly reduced in pregnant ewes. This 'block' of myometrial activity was associated with circulating levels of progesterone which were significantly higher (2\m=.\8\ m=+-\0\m=.\8ng/ml, mean \m=+-\ s.e.m.) than those in non-pregnant animals (0\m=.\4 \m=+-\0\m=.\3 ng/ml). Adenosine injected into the uterine artery produced uterine vasodilatation in both groups, but the log dose\p=n-\response was significantly less in pregnant than in non-pregnant animals (P < 0\m=.\001).Myometrial activity was stimulated by adenosine, particularly in the pregnant group (P < 0\m=.\001

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“…After treatment with 17␤-estradiol (9) or estrogen replacement therapy (8), this impairment was attenuated; that is, adrenergic vasoconstriction was reduced during exercise with the presence of exogenous estrogen. The role of progesterone is less clear; currently, the vascular effects of progesterone alone and in combination with estrogen are inconclusive (10,12,24,40).Given recent reports of blunted ␣-adrenergic responses in young women compared with men at rest and greater muscle blood flow during exercise, we hypothesized that functional sympatholysis would be greater in women than men; that is, women would exhibit less ␣-adrenergic-mediated vasoconstriction than men during exercise. Additionally, female hormones are associated with reduced sympathetic-mediated vasoconstriction; thus we hypothesized that women would exhibit enhanced sympatholysis during the early luteal phase compared with the early follicular phase of the menstrual cycle, when hormone levels are high.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

α-Adrenergic control of blood flow during exercise: effect of sex and menstrual phase

Limberg¹,

Eldridge

Proctor

et al. 2010

Journal of Applied Physiology

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Limberg JK, Eldridge MW, Proctor LT, Sebranek JJ, Schrage WG. ␣-Adrenergic control of blood flow during exercise: effect of sex and menstrual phase. J Appl Physiol 109: 1360-1368, 2010. First published August 19, 2010 doi:10.1152/japplphysiol.00518.2010.-Sex differences exist in autonomic control of the cardiovascular system. This study was designed to directly test sex or female menstrual phase-related differences in ␣-adrenergic control of blood flow during exercise. We hypothesized that women would exhibit reduced ␣-adrenergic vasoconstriction compared with men during exercise; in addition, women would constrict less during the early luteal than the early follicular phase of the female menses. Young men (n ϭ 10) were studied once and women (n ϭ 9) studied twice, once during the early follicular phase and once during the early luteal phase of female menses. We measured forearm blood flow (FBF; Doppler ultrasound of the brachial artery) during rest and steady-state dynamic exercise (15 and 30% of maximal voluntary contraction, 20 contractions/min). A brachial artery catheter was inserted for the local administration of ␣-adrenergic agonists [phenylephrine (PE; ␣1) or clonidine (CL; ␣2)]. Blood flow responses to exercise [forearm vascular conductance (FVC)] were similar between all groups. At rest, infusion of PE or CL decreased FVC in all groups (40 -60% reduction). Vasoconstriction to PE was abolished in all groups at 15 and 30% exercise intensity. Vasoconstriction to CL was reduced at 15% and abolished at 30% intensity in all groups; women had less CL-induced constriction during the early luteal than early follicular phase (P Ͻ 0.017, 15% intensity). These results indicate that vasodilator responses to forearm exercise are comparable between men and women and are achieved through similar paths of ␣-adrenergic vascular control at moderate intensities; this control may differ at low intensities specific to the female menstrual phase. exercise vasodilation; functional sympatholysis THE UNDERSTANDING OF VASCULAR CONTROL MECHANISMS responsible for skeletal muscle blood flow during exercise stems from predominantly male participants. Given the potential for sexspecific differences in physiological control during exercise, these results are limited in application. Evidence from both animal and human studies indicates that women demonstrate greater blood flow to exercising muscles compared with men (19,25,28). The prominent role of the sympathetic nervous system in the integrated exercise response (29, 37) provides support that sex differences in sympathetic control have the potential to influence muscle blood flow responses.At rest, women exhibit reduced vasoconstrictor responses to sympathetic stimulation in both the forearm and calf compared with men (16, 18). One potential mechanism may be related to the vasodilatory effect of estrogen and its ability to inhibit ␣-adrenoceptor binding (32, 33). After acute exposure to increased levels of estrogen, perimenopausal women exhibit blunted norepinephrine (NE) responsi...

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Role of Estradiol-17beta and Progesterone in Regulating Constriction of Ovine Uterine Arteries

Cited by 42 publications

References 0 publications

Uterine blood flow of cows during the oestrous cycle and early pregnancy: effect of the conceptus on the uterine blood supply

Uterine blood flow of cows during the oestrous cycle and early pregnancy: effect of the conceptus on the uterine blood supply

Uterine blood flow, myometrial activity and their response to adenosine during the peri-implantation period in sheep

α-Adrenergic control of blood flow during exercise: effect of sex and menstrual phase

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