Role of erythropoietin and its receptor in the development of endometriosis in rats

Günal, Mehmet Yalçın; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Özdemir, Ekrem Musa; Aslan, İsmail; Eren, Zehra; Ersavas, Cenk; Kılıç, Ertuğrul

doi:10.4274/jtgga.2018.0039

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…• PCO model group: received water for 3 weeks • Group EPO /PCO: received erythropoietin in a dose of 100 IU / kg by intraperitoneal injection 3 days per week for 3 weeks (11) .…”

Section: Induction Of Pco Modelmentioning

confidence: 99%

Erythropoietin, Myoinositol and Metformin Modulate Insulin Sensitivity Indices, Pancreatic Beta Cell Mass and Hepatocellular Changes in a Rat Model of Polycystic Ovary Syndrome

mohammed

Elhaliem

Fanous

et al. 2022

Ain Shams Medical Journal

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Background: Polycystic ovary syndrome (PCOS) is a common health problem in females throughout their reproductive age. Common symptoms of PCOS are hyperandrogenemia, menstrual disorders, and infertility. Metabolic disorders like insulin resistance and steatotic liver are also common. Metformin is most commonly used in the management of hyperglycemia. Erythropoietin and myoinositol were reported to improve insulin sensitivity.Objective: This study aimed to compare the potential therapeutic role of erythropoietin, myoinositol, and the widely used metformin drug against hyperinsulinemia and hepatic injury of the letrozole-induced PCOS model in rats. Materials and methods:Fifty female Wistar rats were classified equally into five groups: The control group and the PCO model group. PCO model was induced by letrozole in a dose of 0.5 mg/kg daily for 3 weeks. Then rats with PCO were administrated: erythropoietin in (EPO/PCO) group, myoinositol in (MYO/PCO) group, or metformin in (MET/PCO) group for the following 21 days. Biochemical and histological studies on the liver and pancreas were done. Immunohistochemical staining with GLUT-1 and insulin was done.Results: PCO rats developed insulin resistance with pancreatic β cell degeneration, hepatocellular injury, and upregulation of hepatic GLUT-1. Metformin, erythropoietin, and myoinositol restored β-cell mass, decreased hyperinsulinemia, and attenuated hepatocellular degeneration via the reduction of stress-induced hepatic GLUT-1. However, erythropoietin was the most effective one of them. Conclusion:Erythropoietin was more effective than metformin and myoinositol in decreasing hyperinsulinemia and attenuation of hepatocellular injury associated with the letrozole-induced model of PCOS.

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“…• PCO model group: received water for 3 weeks • Group EPO /PCO: received erythropoietin in a dose of 100 IU / kg by intraperitoneal injection 3 days per week for 3 weeks (11) .…”

Section: Induction Of Pco Modelmentioning

confidence: 99%

Erythropoietin, Myoinositol and Metformin Modulate Insulin Sensitivity Indices, Pancreatic Beta Cell Mass and Hepatocellular Changes in a Rat Model of Polycystic Ovary Syndrome

mohammed

Elhaliem

Fanous

et al. 2022

Ain Shams Medical Journal

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show abstract

“…1). Finally, the liver volumes were determined according to the ellipsoid formula using these values measured for the livers of newborn cadavers 9,10 The ellipsoid formula (Formula 1) is shown below: Formula 1: Volume = Length × Width × Thickness × 0.52…”

Section: Volume Calculation With Usg Measurementsmentioning

confidence: 99%

Yenidoğan kadavralarında karaciğer hacminin stereolojik olarak hesaplanması

Avnioğlu¹,

Unur²,

Acer³

et al. 2020

Cukurova Medical Journal

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Role of erythropoietin and its receptor in the development of endometriosis in rats

Abstract: Here we provide evidence that EPO is a promising candidate for the treatment of endometriosis. Particularly, our histopathological results indicate that EPO is more effective than its receptor activator Mircera in the development endometriosis.

Cited by 2 publications

References 3 publications

Erythropoietin, Myoinositol and Metformin Modulate Insulin Sensitivity Indices, Pancreatic Beta Cell Mass and Hepatocellular Changes in a Rat Model of Polycystic Ovary Syndrome

Erythropoietin, Myoinositol and Metformin Modulate Insulin Sensitivity Indices, Pancreatic Beta Cell Mass and Hepatocellular Changes in a Rat Model of Polycystic Ovary Syndrome

Yenidoğan kadavralarında karaciğer hacminin stereolojik olarak hesaplanması

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