Role of epigenetics in mycotoxin toxicity: A review

Li, Lulu; He, Ziqi; Shi, Yang; Sun, Huiying; Yuan, Bowei; Cai, Jing; Chen, Jia; Long, Miao

doi:10.1016/j.etap.2023.104154

Cited by 7 publications

(1 citation statement)

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“…AFB1 may also cause the over expressions of CD3 + and CD8 + T cells and results in the down regulations of the expression of anti-inflammatory cytokines IL-4, although an increase in pro-inflammatory cytokines IFN-γ, TNF-α and IL-6 [ 10 , 11 ]. Recent studies have shown that methylation of DNA, modification of RNA and modification of histones are involved in regulating the toxicity of mycotoxins [ 12 ]. AFB1 exposure decreased the phagocytic capacity of macrophages by upregulating the expression of DNA methyltransferases (DNMT1 and 3a) [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Penthorum Chinense Pursh Compound on AFB1-Induced Immune Imbalance via JAK/STAT Signaling Pathway in Spleen of Broiler Chicken

Nabi

et al. 2023

Veterinary Sciences

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Aflatoxin B1(AFB1) is the main secondary metabolite produced by Aspergillus flavus, which is highly toxic, carcinogenic, mutagenic and teratogenic. It can induce immune imbalance in animals or humans. Penthorum chinense Pursh (PCP) is a traditional herbal plant that has been used as a hepatoprotective drug with a long history in China. Based on the theory of traditional Chinese Medicine, we prepared Penthorum chinense Pursh Compound (PCPC) by combining four herbal medicines: 5 g Penthorum chinense Pursh, 5 g Radix bupleuri, 1 g Artemisia capillaris Thunb and 1 g Radix glycyrrhizae. The role of the Penthorum chinense Pursh Compound (PCPC) in preventing AFB1-induced immune imbalance in broiler chickens was studied. A total of 180 broiler chickens were equally distributed in six groups: controls, AFB1, YCHD and high-, medium- and low-dose PCPC treatment groups. After 28 days, broilers were anesthetized, and serum spleen and thymus samples were collected for analysis. Results show that AFB1 significantly increased and decreased the relative organ weight of the spleen and thymus, respectively. Pathological section of hematoxylin/eosin (H&E) stained spleen sections showed that AFB1 resulted in splenic tissue damage. Both the serum levels of Immunoglobulin A (IgA) and Immunoglobulin G (IgG) were suppressed in the AFB1 group. IL-6 was elevated in the AFB1 group. The balance between pro-inflammatory cytokines (IFN-γ and IL-2) and anti-inflammatory cytokine (IL-4) was disturbed by AFB1. The apoptosis-related protein and JAK/STAT pathway-related gene expression indicated that AFB1-induced apoptosis via JAK/STAT pathway. PCPC has proven its immunoprotective effects by preventing AFB1-induced immune imbalance. PCPC can be applied as a novel immune-modulating medicine in broiler chickens. It can be applied as a novel immune modulator in veterinary clinical practice.

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