Role of (−)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers

Abe, Osamu; Ono, Tomoyuki; Sato, Hideyuki; Müller, Fabian; Ogata, Hiroshi; Miura, Itaru; Shikama, Yayoi; Onoue, Satomi; Fromm, Martin F.; Kimura, Junko; Misaka, Shingen

doi:10.1007/s00228-018-2436-2

Cited by 46 publications

(57 citation statements)

References 28 publications

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“…EGCG in improving the efficacy of oral nifedipine for treating pregnancy‐induced severe pre‐eclampsia is safe and effective . And single administration of EGCG may also significantly affect the pharmacokinetics of Nadolol …”

Section: Natural Polyphenols Nrf2 Activators In Multiple Disease Modelsmentioning

confidence: 99%

“…[83] And single administration of EGCG may also significantly affect the pharmacokinetics of Nadolol. [84] Gallic acid (GA, 14), a natural polyphenol, has been shown to have a variety of health-promoting effects. Feng et al showed that GA inhibited t-BHP-induced hepatotoxicity by inducing ERK (extracellular regulated kinase)/Nrf2-mediated antioxidant signaling pathway to increase Nrf2 nuclear translocation and its target protein expression, including HO-1, GCLC (glutamate cysteine ligase catalytic), and GSH (glutathione).…”

Section: Other Polyphenolsmentioning

confidence: 99%

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Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Zhou

Jiang

et al. 2019

Chemistry & Biodiversity

135

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The Keap1‐Nrf2/ARE signaling pathway is an important defense system against exogenous and endogenous oxidative stress injury. The dysregulation of the signaling pathway is associated with many diseases, such as cancer, diabetes, and respiratory diseases. Over the years, a wide range of natural products has provided sufficient resources for the discovery of potential therapeutic drugs. Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1‐Nrf2 protein–protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway. In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1‐Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered. In this view, we summarize the research status of natural polyphenols that have been found with apparent Nrf2 activation and their action modes. On the whole, this review may guide the design of novel Keap1‐Nrf2 activator.

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Section: Natural Polyphenols Nrf2 Activators In Multiple Disease Modelsmentioning

confidence: 99%

Section: Other Polyphenolsmentioning

confidence: 99%

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Zhou

Jiang

et al. 2019

Chemistry & Biodiversity

135

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“…Interestingly, CYP3A-based drug interaction with beverages is confined to grapefruit juice (GFJ), which inhibits CYP3A metabolic activity and thus elevates the bioavailability of drugs that undergo intestinal metabolism mediated by CYP3A (Bailey et al, 1989(Bailey et al, , 1991He et al, 1998;Fukuda et al, 2000). On the other hand, OATP2B1mediated drug interaction with beverages has been shown by coadministration with GFJ, orange juice (OJ), apple juice (AJ), and, most recently, green tea, which inhibits OATP2B1 transport activity, resulting in a decrease of the bioavailability of substrate drugs (Dresser et al, 2002;Misaka et al, 2014;Yu et al, 2017;Abe et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats

et al. 2019

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A recent clinical study reported that the ingestion of apple juice (AJ) markedly reduced the plasma concentration of atenolol; however, our in vitro study showed that atenolol may not be a substrate of organic anion transporting polypeptide 2B1 (OATP2B1), so this AJ-atenolol interaction cannot be explained by inhibition of OATP2B1. On the other hand, we more recently showed that the solution osmolality influences gastrointestinal (GI) water volume, and this may indirectly affect intestinal drug absorption. In this study, we examined whether the osmolality dependence of water dynamics can account for AJ-atenolol interactions by evaluating the GI water volume and the atenolol aborption in the presence of AJ in rats. Water absorption was highest in purified water, followed by saline and isosmotic mannitol solution, and the lowest in AJ, confirming that water absorption is indeed osmolality-dependent. Interestingly, AJ showed apparent water secretion into the intestinal lumen. The intestinal concentration of FD-4, a nonpermeable compound, after administration in AJ was lower than the initial concentration, whereas that in purified water was greater than the initial concentration. Further, the fraction of atenolol absorbed in intestine was significantly lower in AJ or hyperosmotic mannitol solution (adjusted to the osmolality of AJ) than after administration in purified water. Comparable results were observed in an in vivo pharmacokinetic study in rats. Our results indicate that orally administered AJ has a capacity to modulate luminal water volume depending on the osmolality, and this effect may result in significant AJ-atenolol interactions.

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“…Flavonoids (such as epicatechin and catechin), furanocoumarins and alkaloids (such as caffeine) found in fruits, vegetables and herbs have been reported to modulate the activities of drug transporters such as Pglycoprotein and metabolizing enzymes [10,25]. For example, green tea extract and/or (−)-epigallocatechin-3gallate was demonstrated to reduce the bioavailability of quetiapine, sunitinib, clozapine, and nadolol by influencing the activities of drug-metabolizing enzymes and drug transporters [26].…”

Section: Discussionmentioning

confidence: 99%

“…P-glycoprotein (P-gp), a major efflux pump for lipophilic and cationic drugs, and cytochrome P450 enzymes (CYP450s) have been demonstrated to play important roles in the oral bioavailability of many drugs and drugdrug interactions [8,9]. Green tea catechins have been demonstrated to influence the activities of drug transporters such as P-glycoprotein and organic anion transporting polypeptides in vitro [10]. Studies by Misaka et al [11] to probe the effects of the oral administration of (−)-epigallocatechin-3-gallate (EGCG) and green tea extract (GTE) on pharmacokinetic properties of nadolol, revealed a significant decrease in the maximum plasma concentration (C max ) and area under the concentration curve (AUC) of nadolol by 85% and 74%, respectively.…”

Section: Introductionmentioning

confidence: 99%

The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits

Amadi

Nwachukwu

2020

BMC Pharmacol Toxicol

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Background: Cola nitida is commonly chewed in many West African cultures to ease hunger pangs and sometimes for their stimulant and euphoriant qualities. Metoclopramide is a known substrate for P-gp, SULT2A1 and CYP2D6 and studies have revealed that caffeine-a major component of Cola nitida can induce P-glycoprotein (P-gp), SULT2A1 and SULT1A1, hence a possible drug interaction may occur on co-administration. The aim of this study was to investigate the pharmacokinetic interactions of Cola nitida and metoclopramide in rabbits. Methods: The study was performed in two stages using five healthy male rabbits with a 1-week washout period between treatments. Stage one involved oral administration of metoclopramide (0.5 mg/kg) alone while in the second stage, metoclopramide (0.5 mg/kg) was administered concurrently with Cola nitida (0.7 mg/kg). Blood samples were collected after each stage at predetermined intervals and analyzed for plasma metoclopramide concentration using HPLC. Results: Compared with control, the metoclopramide/Cola nitida co-administration produced a decrease in plasma concentration of metoclopramide at all the time intervals except at the 7th hour. The following pharmacokinetic parameters were also decreased: area under the curve (51%), peak plasma concentration (39%), half-life (51%); while an increase in elimination rate constant (113%) and clearance rate (98%) were noted indicating rapid elimination of the drug. A minimal decrease in absorption rate (10%) was also observed. Conclusions: The results of this study reveal a possible herb-drug interaction between Cola nitida and metoclopramide.

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Role of (−)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers

Abstract: EGCG is suggested to be a key contributor to the interaction of green tea with nadolol. Moreover, even a single coadministration of green tea may significantly affect nadolol pharmacokinetics.

Cited by 46 publications

References 28 publications

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats

The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits

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