“…Several physiological situations of nonexcitable cells that require dramatic reorganizations of the cytoskeleton are accompanied by modifications in the PMP. For instance, it has been shown that plasma membrane depolarization occurs and may participate in cell proliferation [Loza et al, 1995;Bianchi et al, 1998;MacFarlane and Sontheimer, 2000;Platoshyn et al, 2000;Milovanova et al, 2006;Raffaghello et al, 2006;Seo et al, 2006], cell differentiation [Greenwood et al, 1996;Gu et al, 2001;Koegel and Alzheimer, 2001], cell migration [Rao et al, 2002], and wound healing [Chifflet et al, 2005]. Moreover, it is well documented that malignant cells from different tissues are depolarized in relation to control tissues and that this depolarization may be related to the higher mitotic rate exhibited by these cells [Marino et al, 1994;Bianchi et al, 1998;Sun et al, 2003].…”