Role of engineered nanocarriers for axon regeneration and guidance: Current status and future trends

GhoshMitra, Somesree; Diercks, David R.; Mills, Nathaniel; Hynds, DiAnna L.; Ghosh, Santaneel

doi:10.1016/j.addr.2011.12.013

Cited by 32 publications

(32 citation statements)

References 173 publications

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“…19 In addition, ZNS-M exhibited an inhibitory effect on neuroglia cell growth, which may help inhibit glial scar formation. 44 In addition to the antioxidant effects, it was also shown that ZNS has the ability to promote neurite elongation in mouse primary motor neurons in a dosedependent manner. 38 In this study, we found that the axon lengths of neurons were obviously elongated in the ZNS and (Figure 7).…”

mentioning

confidence: 99%

Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury

Li¹,

Deng²,

Yuan³

et al. 2017

IJN

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mentioning

confidence: 99%

Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury

Li¹,

Deng²,

Yuan³

et al. 2017

IJN

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“…A major health problem with injuries to the spinal cord and brain is traumatic central nervous system injury reporting of approximately 265,000 and 1.5 million new injuries each year [103-105]. QDs represent a new device of significant potential in neuroscience research, and they are useful for experiments that are limited by the restricted anatomy of neuronal and glial interactions [106].…”

Section: Reviewmentioning

confidence: 99%

“…Application of surface-engineered QDs is an area of nanotechnology probing the details of cellular and molecular processes in neuronal cells [4,107-109]. QD bioconjugates based on surface chemistry can be broadly classified as follows: (1) QDs' surface modified by bioactive molecules and (2) QD-polymer nanocomposites [103]. This advance might be significantly important to assess axon growth pending the regeneration process [103].…”

Section: Reviewmentioning

confidence: 99%

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Quantum dots: synthesis, bioapplications, and toxicity

et al. 2012

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This review introduces quantum dots (QDs) and explores their properties, synthesis, applications, delivery systems in biology, and their toxicity. QDs are one of the first nanotechnologies to be integrated with the biological sciences and are widely anticipated to eventually find application in a number of commercial consumer and clinical products. They exhibit unique luminescence characteristics and electronic properties such as wide and continuous absorption spectra, narrow emission spectra, and high light stability. The application of QDs, as a new technology for biosystems, has been typically studied on mammalian cells. Due to the small structures of QDs, some physical properties such as optical and electron transport characteristics are quite different from those of the bulk materials.

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“…This chain of events eventually results in recruitment of immune cells, apoptosis, disruption of synaptic connections, and also axonal degradation, contraction, and demyelination. 3, 5-7 …”

Section: Spinal Cord Injury: Current Outlookmentioning

confidence: 99%

Nanomedicine for treating spinal cord injury

Tyler

Cheng

2013

Nanoscale

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Spinal cord injury results in significant mortality and morbidity, lifestyle changes, and difficult rehabilitation. Treatment of spinal cord injury is challenging because the spinal cord is both complex to treat acutely and difficult to regenerate. Nanomaterials can be used to provide effective treatments; their unique properties can facilitate drug delivery to the injury site, enact as neuroprotective agents, or provide platforms to stimulate regrowth of damaged tissues. We review recent uses of nanomaterials including nanowires, micelles, nanoparticles, liposomes, and carbon-based nanomaterials for neuroprotection in the acute phase. We also review the design and neural regenerative application of electrospun scaffolds, conduits, and self-assembling peptide scaffolds.

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Role of engineered nanocarriers for axon regeneration and guidance: Current status and future trends

Cited by 32 publications

References 173 publications

Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury

Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury

Quantum dots: synthesis, bioapplications, and toxicity

Nanomedicine for treating spinal cord injury

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