Role of Endothelial Progenitor Cells in Restenosis and Progression of Coronary Atherosclerosis After Percutaneous Coronary Intervention

Abstract

Patients with restenosis have higher numbers of subpopulations of endothelial progenitor cells that incorporate into endothelial cells or play a role in arteriogenesis compared with controls and patients with either progression of coronary atherosclerosis or stable disease.

Endothelial Progenitor Cells Predict Long-Term Prognosis in Patients With Stable Angina Treated With Percutaneous Coronary Intervention

“…12 Briefly, peripheral blood samples were taken after a 14-h overnight fast, the day before PCI. The blood for stem cell assessment was kept at room temperature until analysis within <2 h after drawing.…”

“…Data were processed using prospective assessment of the significance of subpopulations of circulating EPCs in the subsequent occurrence of restenosis or progression of coronary atherosclerosis 8 months after PCI. 12 …”

“…12 The original study was designed to carry out the first ndothelial progenitor cells (EPCs) are a heterologous population of bone marrow-derived cells that play a key role in maintaining homeostasis of the endothelium. 1 In pathologic states, EPCs home to areas of endothelial injury, replace damaged endothelium, and participate in neovascularization.…”

Mobilization of CD34+KDR+ endothelial progenitor cells predicts target lesion revascularization

“…In most studies, EPCs were analyzed with the colony-forming unit endothelial cell assay, which reflects the angiogenic behavior of monocytes and lymphocytes, rather than of progenitor cells. More recently, Pelliccia et al [38] [39,40]. Furthermore, an increase in the number of progenitor cells displaying a predominant in vitro ability to differentiate into smooth muscle cells following stent implantation was reported in patients with ISR [41].…”

Endothelial progenitor cells in diabetes complications

“…Коли-чество ЭПК (CD34+KDR+CD45-и CD133+KDR+CD45-) определяли у пациентов со стабильной стенокардией до проведения ЧКВ голометаллическими стентами. У па-циентов с РВС количество ЭПК было выше по сравнению с контрольной группой и группой пациентов с прогресси-рованием коронарного атеросклероза [62]. В недавно опу-бликованном пятилетнем проспективном исследовании было показано, что повышенное количество ЭПК ассоци-ировалось с увеличением частоты развития сердечно-со-судистых событий, включающих смерть, инсульт, ОИМ, повторную реваскуляризацию в течение 5 лет.…”