Role of endoscopic ultrasound (EUS) in local staging of primary gastric lymphoma: Results of the german-austrian prospective multicenter study

Fischbach, Wolfgang; Kolve, M.-E.; Ohmann, Christian

doi:10.1016/s0016-5107(96)80511-6

Cited by 5 publications

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“…EI2 (infiltration of the muscularis propria), and EII1 (involvement of perigastric lymph nodes). In a prospective study of 77 patients with newly diagnosed gastric lymphoma, endoscopic ultrasound correctly predicted the depth of infiltration (EI1 versus EI2) and the lymph node status (EI versus EII1) in 78 and 75%, respectively, as compared to the gold standard of the pathohistological stage of the resected specimen [24]. The main source of error represented 'positive' lymph nodes in 21% which were characterized by histology as reactive inflammatory but not as neoplastic.…”

Section: Diagnosis and Clinical Staging Proceduresmentioning

confidence: 97%

Clinical Management of Primary Gastric Lymphoma

Fischbach¹

1999

Oncol Res Treat

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Primary gastric lymphomas of MALT (mucosa-associated lymphoid tissue) represent a distinct entity, which is documented by its own histological classification. Our knowledge about all aspects of these lymphoma has increased substantially over the last years. Epidemiological, histomorphological, molecular biological and experimental data clearly underline that Helicobacter pylori infection of the gastric mucosa without doubt plays an important role in both the development and progression of MALT lymphomas. Considering histological malignancy (low- and high-grade lymphomas) and dissemination of the disease (stage) as decisive prognostic factors and therapeutical determinants, endoscopic bioptical diagnosis as well as endoscopic ultrasound are of major importance in establishing diagnosis and clinical stage. In case of localized low-grade lymphoma, eradication of Helicobacter pylori offers a promising therapeutic option. Surgical resection and radiochemotherapy have proven to be effective treatment modalities. There is a need for randomized trials to clarify whether operative or conservative therapeutic strategies have to be favored in the future.

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Section: Diagnosis and Clinical Staging Proceduresmentioning

confidence: 97%

Clinical Management of Primary Gastric Lymphoma

Fischbach¹

1999

Oncol Res Treat

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“…There is some evidence from a small series that success or failure of H pylori eradication therapy can be predicted by endoscopic ultrasound (31). In a prospective study of 77 patients with newly diagnosed gastric lymphoma, endoscopic ultrasound correctly predicted the depth of tumour infiltration (stage EI1 versus EI2) and the lymph node status (stage EI versus EII1) in 78% and 75%, respectively, compared with the gold standard of the pathohistological stage of the resected specimen (32). The main source of error was 'positive' lymph nodes in 21% of patients that were found at histology to be inflammatory reactions and not neoplastic changes.…”

Section: Diagnosis and Clinical Staging Proceduresmentioning

confidence: 99%

Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy

Fischbach

1999

Canadian Journal of Gastroenterology and Hepatology

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Primary gastric lymphoma of mucosa-associated lymphoid tissue (MALT) is a distinct entity with its own histological classification. Epidemiological, histomorphological, molecular biological and experimental data clearly underline that infection of the gastric mucosa by Helicobacter pylori plays an important role in both the development and progression of MALT lymphoma. Considering the histological grade of malignancy and dissemination (stage) of the disease as decisive prognostic factors, and therapeutic determinants, endoscopic bioptical diagnosis and endoscopic ultrasound are of particular importance. In cases of localized (stage 1), low grade lymphoma, eradication of H pylori offers a promising and fascinating therapeutic option. Surgical resection, radiotherapy or chemotherapy, and their combination, have proven to be effective treatment modalities. There is a need to clarify whether operative or conservative therapeutic strategies should be favoured in the future.

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“…Erstmals berichteten Wotherspoon et al 1993 über die komplette Regression niedrig maligner Magenlymphome des MALT in 5 von 6 Fällen nach erfolgreicher Eradikation [26]. In diesem Zusammenhang muû auf die diagnostische Unsicherheit der endoskopisch-bioptischen Diagnostik und des endoskopischen Ultraschalls im Vergleich zum Goldstandard des pathohistologischen Grading und Stadiums hingewiesen werden [8,23]. Die Rate kompletter Lymphomregressionen variiert nach diesen Daten zwischen 58 und 90 %.…”

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Helicobacter and lymphoma

Fischbach

1998

Chirurg

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The gastrointestinal tract represents the most common extranodal site of malignant non-Hodgkin's lymphoma. Epidemiological, histomorphological, molecular biological and experimental animal studies undoubtedly underline the important role of Helicobacter pylori for the development and progression of primary gastric lymphoma of MALT (mucosa-associated lymphoid tissue). Eradication of Helicobacter pylori is an important therapeutic option in low-grade gastric, MALT lymphoma of localized stage E I.

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Role of endoscopic ultrasound (EUS) in local staging of primary gastric lymphoma: Results of the german-austrian prospective multicenter study

Cited by 5 publications

References 0 publications

Clinical Management of Primary Gastric Lymphoma

Clinical Management of Primary Gastric Lymphoma

Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy

Helicobacter and lymphoma

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