Role of endoplasmic reticulum stress in depression (Review)

Mao, Jiaxin; Hu, Ying; Ruan, Lifang; Ji, Yonghoon; Lou, Zhongze

doi:10.3892/mmr.2019.10789

Cited by 38 publications

(38 citation statements)

References 81 publications

(81 reference statements)

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“…Overall, this response leads to stress of the endoplasmic reticulum (ER), a central organelle that regulates stress responses in both plant and animal cells 108 . The stresses affecting protein folding lead to ER stress, which is communicated to the nucleus via the unfolded protein response (UPR), a cellular homeostatic response to ER stress that is reported to be associated with translation attenuation and psychiatric disorders in humans 109 .…”

Section: Resultsmentioning

confidence: 99%

Acute environmental temperature variation affects brain protein expression, anxiety and explorative behaviour in adult zebrafish

Nonnis

Angiulli

Maffioli

et al. 2021

Sci Rep

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This study investigated the effect of 4-d acute thermal treatments at 18 °C, 26 °C (control) and 34 °C on the nervous system of adult zebrafish (Danio rerio) using a multidisciplinary approach based on behavioural tests and brain proteomic analysis. The behavioural variations induced by thermal treatment were investigated using five different tests, the novel tank diving, light and dark preference, social preference, mirror biting, and Y-Maze tests, which are standard paradigms specifically tailored for zebrafish to assess their anxiety-like behaviour, boldness, social preference, aggressiveness, and explorative behaviour, respectively. Proteomic data revealed that several proteins involved in energy metabolism, messenger RNA translation, protein synthesis, folding and degradation, cytoskeleton organisation and synaptic vesiculation are regulated differently at extreme temperatures. The results showed that anxiety-like behaviours increase in zebrafish at 18 °C compared to those at 26 °C or 34 °C, whereas anxiety-related protein signalling pathways are downregulated. Moreover, treatments at both 18 °C and 34 °C affect the exploratory behaviour that appears not to be modulated by past experiences, suggesting the impairment of fish cognitive abilities. This study is the continuation of our previous work on the effect of 21-d chronic treatment at the same constant temperature level and will enable the comparison of acute and chronic treatment effects on the nervous system function in adult zebrafish.

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Section: Resultsmentioning

confidence: 99%

Acute environmental temperature variation affects brain protein expression, anxiety and explorative behaviour in adult zebrafish

Nonnis

Angiulli

Maffioli

et al. 2021

Sci Rep

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show abstract

“…Its function is not completely understood yet, however, its malfunction induces endoplasmic reticulum stress [18]. Endoplasmic reticulum stress activates the unfolded protein response and mediates the pathogenesis of psychiatric diseases when the damage occurs in the hippocampus, the amygdala and striatum [48], where wolframin is greatly present [17]. Therefore, food possession in dogs could be partially due to the polymorphism of the WFS1 gene.…”

Section: Discussionmentioning

confidence: 99%

The molecular effect of a polymorphic microRNA binding site of Wolfram syndrome 1 gene in dogs

et al. 2020

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Background: Although the molecular function of wolframin remains unclear, the lack of this protein is known to cause stress in the endoplasmic reticulum. Some variants in the Wolfram Syndrome 1 gene (WFS1) were associated with various neuropsychiatric disorders in humans, such as aggressiveness, impulsivity and anxiety. Results: Here we present an in silico study predicting a single nucleotide polymorphism (rs852850348) in the canine WFS1 gene which was verified by direct sequencing and was genotyped by a PCR-based technique. We found that the rs852850348 polymorphism is located in a putative microRNA (cfa-miR-8834a and cfa-miR-1838) binding site. Therefore, the molecular effect of allelic variants was studied in a luciferase reporter system that allowed assessing gene expression. We demonstrated that the variant reduced the activity of the reporter protein expression in an allele-specific manner. Additionally, we performed a behavioral experiment and investigated the association with this locus to different performance in this test. Association was found between food possessivity and the studied WFS1 gene polymorphism in the Border collie breed. Conclusions: Based on our findings, the rs852850348 locus might contribute to the genetic risk of possessivity behavior of dogs in at least one breed and might influence the regulation of wolframin expression.

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“…Rough ER is the main site for proteins synthesis, modification, proteins folding and assembly into stable secondary and tertiary structures, as well as the secretion of proteins ( Young, 2017 ). The various stressors including hypoxia, hypoglycemia, stress, calcium deficiency, high-fat diet, and oxidative stress, can disturb the protein folding process, resulting in the accumulation of unfolded and misfolded proteins in the ER, which is called ERS ( Mao et al, 2019 ). The accumulation of unfolded proteins in ER triggers a stable signal network called UPR to reduce the overload caused by unfolded protein.…”

Section: Overview Of Ersmentioning

confidence: 99%

The Role of the Signaling Pathways Involved in the Effects of Hydrogen Sulfide on Endoplasmic Reticulum Stress

Zhao

et al. 2021

Front. Cell Dev. Biol.

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Endoplasmic reticulum (ER) is a kind of organelle with multiple functions including protein synthesis, modification and folding, calcium storage, and lipid synthesis. Under stress conditions, ER homeostasis is disrupted, which is defined as ER stress (ERS). The accumulation of unfolded proteins in the ER triggers a stable signaling network named unfolded protein response (UPR). Hydrogen sulfide is an important signal molecule regulating various physiological and pathological processes. Recent studies have shown that H2S plays an important role in many diseases by affecting ERS, but its mechanism, especially the signaling pathways, is not fully understood. Therefore, in this review, we summarize the recent studies about the signaling pathways involved in the effects of H2S on ERS in diseases to provide theoretical reference for the related in-depth researches.

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Role of endoplasmic reticulum stress in depression (Review)

Cited by 38 publications

References 81 publications

Acute environmental temperature variation affects brain protein expression, anxiety and explorative behaviour in adult zebrafish

Acute environmental temperature variation affects brain protein expression, anxiety and explorative behaviour in adult zebrafish

The molecular effect of a polymorphic microRNA binding site of Wolfram syndrome 1 gene in dogs

The Role of the Signaling Pathways Involved in the Effects of Hydrogen Sulfide on Endoplasmic Reticulum Stress

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