Role of Endocrinological Factors in the Pathogenesis of Idiopathic Edema

Shimamoto, Kazuaki; Tanaka, Shigemichi; Ando, Toshiaki; Nakao, Takashi; Nakahashi, Yasuyuki; Miyahara, Mitsuo

doi:10.1620/tjem.130.71

Cited by 7 publications

(4 citation statements)

References 15 publications

(10 reference statements)

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“…The other common type of edema we need to differentiate is idiopathic edema. Idiopathic edema is a state that primarily affects women in the absence of hepatic, renal, and cardiac diseases (7)(8)(9). The diagnosis is made by physical and clinical assessments, and diuretics are the common treatment (10).…”

Section: Discussionmentioning

confidence: 99%

Deanxit and tandospirone relieved unexplained limb edema in a depressed pituitary adenoma survivor: A case report

Dong

Fang²,

Li³

et al. 2022

Front. Psychiatry

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Our case report describes a 45-year-old woman who suffered from limb edema for 2 months. We focused on tumor recurrence and other common potential diseases based on the pituitary adenoma history. However, none of the examinations showed any abnormality. Later, her continuous complaints about the family relationship and depressed mood came into sight, and a psychiatry consultation was arranged. Following that, she was diagnosed with major depressive disorder. After several days of Deanxit and tandospirone treatment, the patient's limb edema dramatically subsided. This is the first case of limb edema associated with depression. This highlights the importance of awareness of mental illness for non-psychiatrists, especially in patients with severe somatic symptoms, but with negative results.

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Section: Discussionmentioning

confidence: 99%

Deanxit and tandospirone relieved unexplained limb edema in a depressed pituitary adenoma survivor: A case report

Dong

Fang²,

Li³

et al. 2022

Front. Psychiatry

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“…The four most common causes of edema include an increase in hydrostatic capillary pressure (commonly seen in heart failure patients), a decrease in oncotic capillary pressure (common to patients with liver disorders, nephrotic syndromes or malnutrition), an increase in capillary permeability (as seen with damage from burns or inflammation) or an increase in interstitial oncotic pressure (associated with leukocyte-mediated injury and endothelial cell growth) [2][3][4]. When the interstitial fluid surpasses the ability of the lymphatic system to return it to circulation, edema will be formed due to the increase in interstitial oncotic pressure.…”

Section: Discussionmentioning

confidence: 99%

“…Edema is the excess of fluid outflow into the interstitium and is most commonly caused by an increase in hydrostatic capillary pressure, a decrease in oncotic capillary pressure, an increase in capillary permeability or an increase in interstitial oncotic pressure [1]. Idiopathic edema is a state which primarily affects women in the absence of hepatic, renal, and cardiac diseases [2,3]. Diagnosis is generally made by physical and clinical assessment.…”

Section: Introductionmentioning

confidence: 99%

Idiopathic Edema: A Case Report

Veluri

Badwal

2019

Cureus

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Edema occurs when excess fluid is retained by interstitial tissue and is associated with several systemic conditions. The diagnosis of edema is generally made by physical and clinical assessment, and diuretics are the common treatment. Idiopathic edema predominantly affects women and occurs in patients who do not have any other pre-existing systemic problems. The etiology behind idiopathic edema has yet to be determined. We present a case of a 46-year-old woman diagnosed with idiopathic edema.

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“…stimulation of the kallikrein-bradykinin system [13]. This may be of particular importance since idiopathic edema patients were found to have a decreased kallikrein excretion [14]. The failure of dopaminergic treatment speaks against the role of dopamine deficiency at least in this clinical setting.…”

Section: Discussionmentioning

confidence: 99%

Extreme Diuretic Dependence in Idiopathic Edema: Mechanisms, Prevention and Therapy

Küchel

Éthier

1998

Am J Nephrol

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Idiopathic edema patients abusing diuretics are occasionally becoming dependent to such a degree on increasing doses of diuretics that their withdrawal results in severe cardiorespiratory failure, occasionally even pulmonary edema. Two such patients are described and 1 is investigated in depth as to the mechanism of the diuretic abuse-induced excessive tubular avidity for sodium. An extreme diuretic-induced secondary hyperaldosteronism and atrial natriuretic factor suppression, although tapering off when diuretics are stopped, results in a continuous tubular sodium hyper-reabsorption. Since the most affected patient was deprived of the benefits of converting enzyme inhibitors because of their side effects, the only way to partially overcome this condition was a generous combination of several diuretics acting at several segments of the nephron. This contrasted with a similar patient who was relatively well controlled by a converting enzyme inhibitor combined with lower dose diuretics. Diuretic abuse-induced secondary hyperaldosteronism and diuretic resistance are apparently best prevented by converting enzyme inhibitors. When nonpharmacological preventive measures fail, converting enzyme inhibitors are preferable to diuretics as the first-choice treatment of idiopathic edema patients.

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Role of Endocrinological Factors in the Pathogenesis of Idiopathic Edema

Cited by 7 publications

References 15 publications

Deanxit and tandospirone relieved unexplained limb edema in a depressed pituitary adenoma survivor: A case report

Deanxit and tandospirone relieved unexplained limb edema in a depressed pituitary adenoma survivor: A case report

Idiopathic Edema: A Case Report

Extreme Diuretic Dependence in Idiopathic Edema: Mechanisms, Prevention and Therapy

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