Role of Embedded Pure Xenogenous Bovine Platelet Gel on Experimental Tendon Healing, Modelling and Remodelling

Oryan, Ahmad; Moshiri, Ali; Meimandi-Parizi, Abdolhamid

doi:10.1007/s40259-014-0107-0

Cited by 14 publications

(10 citation statements)

References 40 publications

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“…Clinical usage of PRP has been reported to have few significant complications7, which coincides with the finding of the current study. The fact that FD-PRP achieved the similar tendency for trabecular formation and mechanical strength to BMP indicates that FD-PRP achieves accelerated bone formation in the osteoinductive manner as BMP does30. This should be investigated in detail in a future study.…”

Section: Discussionmentioning

confidence: 87%

Freeze-Dried Platelet-Rich Plasma Accelerates Bone Union with Adequate Rigidity in Posterolateral Lumbar Fusion Surgery Model in Rats

Orita

Kubota

Kamoda

et al. 2016

Sci Rep

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Fresh platelet-rich plasma (PRP) accelerates bone union in rat model. However, fresh PRP has a short half-life. We suggested freeze-dried PRP (FD-PRP) prepared in advance and investigated its efficacy in vivo. Spinal posterolateral fusion was performed on 8-week-old male Sprague-Dawley rats divided into six groups based on the graft materials (n = 10 per group): sham control, artificial bone (A hydroxyapatite–collagen composite) –alone, autologous bone, artificial bone + fresh-PRP, artificial bone + FD-PRP preserved 8 weeks, and artificial bone + human recombinant bone morphogenetic protein 2 (BMP) as a positive control. At 4 and 8 weeks after the surgery, we investigated their bone union–related characteristics including amount of bone formation, histological characteristics of trabecular bone at remodeling site, and biomechanical strength on 3-point bending. Comparable radiological bone union was confirmed at 4 weeks after surgery in 80% of the FD-PRP groups, which was earlier than in other groups (p < 0.05). Histologically, the trabecular bone had thinner and more branches in the FD-PRP. Moreover, the biomechanical strength was comparable to that of autologous bone. FD-PRP accelerated bone union at a rate comparable to that of fresh PRP and BMP by remodeling the bone with thinner, more tangled, and rigid trabecular bone.

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Section: Discussionmentioning

confidence: 87%

Freeze-Dried Platelet-Rich Plasma Accelerates Bone Union with Adequate Rigidity in Posterolateral Lumbar Fusion Surgery Model in Rats

Orita

Kubota

Kamoda

et al. 2016

Sci Rep

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“…We decalcified turtle bone to expose osteoinductive growth factors from the mineralized matrix, thereby enhancing the bone formation process. There is higher variability in concentration of BMPs among the same DBM (ORYAN et al, 2014b). This variability questions DBM product reliability and, possibly, their efficacy in providing consistent osteoinduction .…”

Section: Discussionmentioning

confidence: 99%

“…DBM is able to function as a graft extender in humans (LIEBSCHNER, 2004). After demineralization, DBM retains much of the proteinaceous components native to bone, with small amounts of calcium-based solids, inorganic phosphates and some trace cell debris (ORYAN et al, 2014b). Previous experimental studies have demonstrated that the implantation of DBM into subcutaneous or muscular sites induces the proliferation of mesenchymal stem cells which differentiate to cartilage cells (MOSHIRI and ORYAN, 2013) and the synthesis of cartilage tissues, and subsequently there is a process similar to endochondral ossification.…”

Section: Discussionmentioning

confidence: 99%

Characterization of turtle demineralized bone matrix (DBM) and turtle bone in rat radial bone defects; radiological, histopathological, biomechanical and scanning electron microscopic evaluation

2017

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Bone grafts are used to treat various disorders, including delayed union and nonunion of fractures, congenital pseudoarthrosis, and osseous defects from trauma, infection, and tumors. The disadvantages of allografts, such as disease transmission, have led to the exploration of xenografts as an alternative grafting material. We used turtle DBM and turtle bone grafts in this study. A critical size defect of 2.5 times diameter elongation was created in the radial diaphysis of 16 rats in this study. The rats were divided into 4 groups: defect as control˗, autograft as control+, turtle bone and turtle DBM. The results of radiological, histopathological, biomechanical and scanning electron microscopic evaluation of groups were compared. The biomechanical and radiological evaluation shows that there was no significant difference between groups; but histopathological evaluation shows significant differences between groups in union and cancellous bone. The turtle DBM group had the same result as control+ and was superior to the other groups.

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“…42,49,88 Platelet rich plasma (PRP) and its other forms (gel and glue) can be obtained from patients' anticoagulant peripheral blood by one or two step centrifugation. 107,119,[121][122][123] PRPs are different from each other based on their platelet concentration which is 1.5 to 10 times greater than the physiologic plasma. In addition, they are different based on their source (auto-, allo-, and xenograft), and also presence/absence and concentration of white blood cells.…”

Section: Co-administration Of Healing Promotive Factors and Stem Cellmentioning

confidence: 99%

“…In the platelet gel, the platelets release their growth factors before implantation of the graft so that the beneficial effects of platelet gel start to contribute in the healing process at the surgical implantation time. 107,123 Presence of WBCs in PRP may modulate the inflammatory phase of bone healing. The most important growth factor of platelet concentrates is PDGF which is responsible for several osteoinductive and osteoconductive events.…”

Section: Co-administration Of Healing Promotive Factors and Stem Cellmentioning

confidence: 99%

Role of Simvastatin on fracture healing and osteoporosis: a systematic review onin vivoinvestigations

Moshiri

Sharifi

Oryan

2016

Clin Exp Pharma Physio

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SUMMARYSimvastatin is a lipid lowering drug whose beneficial role on bone metabolism was discovered in 1999. Several in vivo studies evaluated its role on osteoporosis and fracture healing, however, controversial results are seen in the literature. For this reason, Simvastatin has not been the focus of any clinical trials as yet. This systematic review clears the mechanisms of action of Simvastatin on bone metabolism and focuses on in vivo investigations that have evaluated its role on osteoporosis and fracture repair to find out (i) whether Simvastatin is effective on treatment of osteoporosis and fracture repair, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. Simvastatin induces osteoinduction by increasing osteoblast activity and differentiation and inhibiting their apoptosis. It also reduces osteoclastogenesis by decreasing both the number and activity of osteoclasts and their differentiation. Controversial results between the in vivo studies are mostly due to the differences in the route of administration, dose, dosage and carrier type. Local delivery of Simvastatin through controlled drug delivery systems with much lower doses and dosages than the systemic route seems to be the most valuable option in fracture healing. However, systemic delivery of Simvastatin with much higher doses and dosages than the clinical ones seems to be effective in managing osteoporosis. Simvastatin, in a particular range of doses and dosages, may be beneficial in managing osteoporosis and fracture injuries. This review showed that Simvastatin is effective in the treatment of osteoporosis and fracture healing.

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Role of Embedded Pure Xenogenous Bovine Platelet Gel on Experimental Tendon Healing, Modelling and Remodelling

Abstract: Bovine platelet gel-embedded artificial tendon could be considered as a new option in reconstruction and healing of large tendon defects.

Cited by 14 publications

References 40 publications

Freeze-Dried Platelet-Rich Plasma Accelerates Bone Union with Adequate Rigidity in Posterolateral Lumbar Fusion Surgery Model in Rats

Freeze-Dried Platelet-Rich Plasma Accelerates Bone Union with Adequate Rigidity in Posterolateral Lumbar Fusion Surgery Model in Rats

Characterization of turtle demineralized bone matrix (DBM) and turtle bone in rat radial bone defects; radiological, histopathological, biomechanical and scanning electron microscopic evaluation

Role of Simvastatin on fracture healing and osteoporosis: a systematic review onin vivoinvestigations

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