Role of Electrocardiographic Tpeak-Tend for the Prediction of Ventricular Arrhythmic Events in the Brugada Syndrome

Tpeak‐Tend, Tpeak‐Tend/QT ratio and Tpeak‐Tend dispersion for risk stratification in Brugada Syndrome: A systematic review and meta‐analysis

“…A total of 29 and 57 entries were retrieved from PubMed and Embase, respectively. Nine studies met the inclusion criteria and were included in our final meta‐analysis . In this meta‐analysis, a total of 1740 subjects with Brugada Syndrome were included (mean age 45 years old, 80% male).…”

“…Separate meta‐analyses were conducted to compare the different T peak ‐T end parameters between patients with and without SCN5A mutations. Two of the included studies provided sufficient information for such analyses . No significant difference in T peak ‐T end (mean difference = 8.2 ms, 95% CI: −6.7 to 23.2 ms, P = 0.28; I 2 = 59%; Figure ), T peak ‐T end /QT ratio (mean difference = −0.006 ms, 95% CI: −0.023 to 0.011 ms, P = 0.47; I 2 = 24%; Figure ) or T peak ‐T end dispersion (mean difference = 5.2 ms, 95% CI: −2.9 to 13.2 ms, P = 0.21; I 2 = 31%; Figure ) was observed between patients with and without SCN5A mutations.…”

“…Subsequent clinical studies have demonstrated that, confirmed recently in a systematic review and meta‐analysis from our group, that T peak ‐T end prolongation significantly elevated the risk of ventricular tachy‐arrhythmias and/or SCD in heart failure, ischemic heart disease, Brugada syndrome, hypertension, and the general population. Recently, Mugnai and colleagues in a total of 448 subjects found no significant differences T peak ‐T end intervals, (T peak ‐T end )/QT ratio or T peak ‐T end dispersion between patients with VT/VF requiring anti‐tachycardia pacing or with sudden death, and those who were asymptomatic . Similarly, in a separate population of 471 subjects, Morita and colleagues found no significance difference in T peak ‐T end intervals between patients with syncope or VT/VF and asymptomatic patients .…”

“…However, not all studies have shown an association between higher T peak ‐T end intervals, (T peak ‐T end )/QT ratio or T peak ‐T end dispersion with an arrhythmogenic phenotype in Brugada Syndrome. Recently, Mugnai and colleagues conducted one of the largest retrospective studies to date, including a total of 448 patients with spontaneous or drug induced type 1 Brugada pattern . They found no statistically significant difference in all three indices between asymptomatic subjects and patients with syncope and malignant arrhythmias.…”

Can abnormal dispersion of ventricular repolarization be a predictor of mortality in arrhythmogenic right ventricular cardiomyopathy: The importance of Tp‐e interval

“…Previous studies have indicated that the time interval between the peak and the end of the T wave (Tp-e interval) has been proposed as markers of transmural dispersion of repolarization to identify the patients at higher risk of malignant arrhythmic events (Hevia et al, 2006;Morin et al, 2012;Mugnai et al, 2017). Myocardial repolarization has been assessed with QT interval (QT), corrected QT interval (QTc), QT dispersion (QTd), and transmural dispersion of repolarization.…”