Role of elastography strain ratio and TIRADS score in predicting malignant thyroid nodule

Okasha, Hussein Hassan; Mansor, Mona; Sheriba, Nermine; Assem, Maha; Abdelfattah, Yasmine; Ashoush, Omar; Rakha, Maha; Abdelfattah, Dalia; El-Sawy, Shereen Sadik; Elshenoufy, Mai; Mohsen, Ahmed; Sedrak, Heba; Abdellatif, Abeer Awad

doi:10.20945/2359-3997000000283

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…In breast, thyroid, and pancreatic cancers, elastography is recognized as a promising technique because cancer tissue is stiffer than normal tissue 10 . Breast cancer has been actively studied for a long time 11 , and recently, elastography has also been studied in the differentiation of benign and malignant soft tissue tumors 12 , predicting malignant thyroid nodules 13 , detecting pancreatic cancer using endoscopic ultrasonography 14 , 15 , and assessing liver disease 16 .…”

Section: Discussionmentioning

confidence: 99%

Role of the elastography strain ratio using transrectal ultrasonography in the diagnosis of prostate cancer and clinically significant prostate cancer

Yoo

Koo

Chung

et al. 2022

Sci Rep

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This study investigated the efficacy of the elastography strain ratio (ESR) as a predictor of prostate cancer (PCa) in targeted prostate biopsy. In total, 257 patients who underwent magnetic resonance imaging-targeted biopsy were enrolled. Before biopsy, we placed regions of interest (zone A and B) in the lesion and levator ani. The ESR was measured as zone A/zone B. Multivariate analyses were performed to predict PCa and clinically significant PCa. There were 206 (71.5%) positive cancer lesions. No difference in digit rectal examination findings was found between patients with and without PCa. For predicting clinically significant PCa, an ESR ≥ 6.8 was significantly higher in the PCa (+) group than in the PCa (−) group (p < 0.001). The area under the receiver operating characteristic curve (AUC) for the conventional variables (model 1) plus the ESR was 0.845, which was significantly higher than that for model 1 (p = 0.001). In prostate imaging reporting and data system score 3 lesions, an ESR ≥ 4.6 was a significant predictor of PCa (p = 0.002). The AUC in model 1 plus the ESR was 0.856, which was significantly higher than that in model 1 alone (p = 0.017). The ESR is useful for predicting clinically significant PCa.

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Section: Discussionmentioning

confidence: 99%

Role of the elastography strain ratio using transrectal ultrasonography in the diagnosis of prostate cancer and clinically significant prostate cancer

Yoo

Koo

Chung

et al. 2022

Sci Rep

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show abstract

Section: Discussionmentioning

confidence: 99%

Role of the elastography strain ratio using transrectal ultrasonography in the diagnosis of prostate cancer and clinically significant prostate cancer

Yoo

Koo

Chung

et al. 2022

Preprint

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INTRODUCTIONThis study investigated the efficacy of the elastography strain ratio (ESR) as a predictor of prostate cancer (PCa) in targeted prostate biopsy.METHODSIn total, 257 patients who underwent magnetic resonance imaging-targeted biopsy were enrolled. Before biopsy, we placed regions of interest (zone A and B) in the lesion and levator ani. The ESR was measured as zone A/zone B. Multivariate analyses were performed to predict PCa and clinically significant PCa.RESULTSThere were 206 (71.5%) positive cancer lesions. No difference in digit rectal examination findings was found between patients with and without PCa. For predicting clinically significant PCa, an ESR ≥ 6.8 was significantly higher in the PCa (+) group than in the PCa (−) group (p < 0.001). The area under the receiver operating characteristic curve (AUC) for the conventional variables (model 1) plus the ESR was 0.845, which was significantly higher than that for model 1 (p = 0.001). In prostate imaging reporting and data system score 3 lesions, an ESR ≥ 4.6 was a significant predictor of PCa (p = 0.002). The AUC in model 1 plus the ESR was 0.856, which was significantly higher than that in model 1 alone (p = 0.017).CONCLUSIONSThe ESR is useful for predicting clinically significant PCa.

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“…In addition to training and standardization, continuous monitoring of reliability statistics and formal feedback mechanisms have improved inter‐rater reliability estimates in observational studies 65 . Additionally, revision of modern risk criteria via the proposed inclusion of strain elastography or color doppler may improve objectivity and reduce variability between radiologists 66,67 . Up to 46% of thyroid ultrasounds are ordered unnecessarily and not in agreement with Choosing Wisely recommendations 68 .…”

Section: Discussionmentioning

confidence: 99%

Inter‐Rater Reliability of Thyroid Ultrasound Risk Criteria: A Systematic Review and Meta‐Analysis

et al. 2022

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Objective: The most commonly employed diagnostic criteria for identifying thyroid nodules include Thyroid Imaging and Reporting Data System (TI-RADS) and American Thyroid Association (ATA) guidelines. The purpose of this systematic review and meta-analysis is to determine the inter-rater reliability of thyroid ultrasound criteria.Methods: We performed a library search of MEDLINE (Ovid), EMBASE (Ovid), and Web of Science for full-text articles published from January 2005 to June 2022. We included full-text primary research articles that used TI-RADS and/or ATA guidelines to evaluate thyroid nodules in adults. These included studies must have calculated inter-rater reliability using any validated metric. The Quality Appraisal for Reliability Studies (QAREL) was used to assess study quality. We planned for a random-effects meta-analysis, in addition to covariate and publication bias analyses. This study was performed in accordance with Preferred Reporting Items for a Systematic Review and Meta-analysis guidelines and registered prior to conduction (International prospective register of systematic reviews-PROSPERO: CRD42021275072).Results: Of the 951 articles identified via the database search, 35 met eligibility criteria. All studies were observational. The most commonly utilized criteria were ACR Thyroid Imaging and Reporting Data System (TI-RADS) and/or ATA criteria, while the majority of studies employed Κ statistics. For ACR TI-RADS, the pooled Κ was 0.51 (95% confidence interval [CI]: 0.42, 0.57; n = 7) while for ATA, the pooled Κ was 0.52 (95% CI: 0.37, 0.67; n = 3). Due to the small number of studies, covariate or publication bias analyses were not performed.Conclusion: Ultrasound criteria demonstrate moderate inter-rater reliability, but these findings are impacted by poor study quality and a lack of standardization.

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Role of elastography strain ratio and TIRADS score in predicting malignant thyroid nodule

Cited by 7 publications

References 28 publications

Role of the elastography strain ratio using transrectal ultrasonography in the diagnosis of prostate cancer and clinically significant prostate cancer

Role of the elastography strain ratio using transrectal ultrasonography in the diagnosis of prostate cancer and clinically significant prostate cancer

Role of the elastography strain ratio using transrectal ultrasonography in the diagnosis of prostate cancer and clinically significant prostate cancer

Inter‐Rater Reliability of Thyroid Ultrasound Risk Criteria: A Systematic Review and Meta‐Analysis

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